CAS: 899452-26-7; 5-Bromo-2-(Difluoromethoxy)Pyridine

英文名称5-Bromo-2-(Difluoromethoxy)Pyridine
中文名称5-溴-2-(二氟甲氧基)吡啶
IUPAC名称5-bromo-2-(difluoromethoxy)pyridine
其它别名2-(二氟甲氧基)-5-溴吡啶; 5-Bromo-2-(Difluoromethoxy)
CAS编号899452-26-7
MFCD编号:MFCD11977440
EINECS号:810-341-4
分子式:C6H4BrF2NO分子量:224.0
产品CID: 1929740
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: TUKUVGKMNSUOJF-UHFFFAOYSA-N
InChI=1S/C6H4BrF2NO/c7-4-1-2-5(10-3-4)11-6(8)9/h1-3,6H
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数2.0

相似化合物

886371-77-3 13472-85-0 1079352-13-8

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
易燃液体类别4
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H227 |可燃液体
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

欧盟法规

C&L通报

上下游产品

2,2-difluoro-2-(fluorosulfonyl)acetic acid 5-bromopyridin-2(1H)-one Ethyl bromodifluoroacetate sodium chlorodifluoroacetate6-(difluoromethoxy)nicotinaldehyde 6-(difluoromethoxy)pyridin-3-ol 2-difluoromethoxy-5-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-pyridine tert-butyl (3S)-3-(benzyl((1R)-1-phenylethyl)amino)-3-(6-(difluoromethoxy)pyridin-3-yl)propanoate

合成工艺路线路线简述

13466-38-1 + 1717-59-5 = 899452-26-7
反应条件:1.1 Reagents: Sodium Sulfate Solvents: Acetonitrile; 4.5 H,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
标题:Facile One-Pot Synthesis Of N-Difluoromethyl-2-Pyridone Derivatives
作者:Ando,Makoto; Wada,Toshihiro; Sato,Nagaaki
参考文献:Organic Letters 日期:2006 卷标:8(17) 页码:3805-3808]

115262-01-6 + 13466-38-1 = 899452-26-7
反应条件:1.1 Reagents: Sodium Carbonate Solvents: Acetonitrile; 10 Min,60 °C1.2 1 H,60 °C
标题:Chemoselective N- And O-Difluoromethylation Of 2-Pyridones,Isoquinolinones,And Quinolinones With Tmscf2Br
作者:Zhu,Ziyue; Krishnamurti,Vinayak; Ispizua-Rodriguez,Xanath; Barrett,Colby; Prakash,G. K. Surya
参考文献:Organic Letters 日期:2021 卷标:23(16) 页码:6494-6498]

13466-38-1 + 1895-39-2 = 899452-26-7 + 832735-61-2
反应条件:1.1 Solvents: Acetonitrile; 20 H,Rt -> Reflux; Reflux -> Rt1.2 Reagents: Ammonium Chloride Solvents: Water; Rt
标题:Facile One-Pot Synthesis Of N-Difluoromethyl-2-Pyridone Derivatives
作者:Ando,Makoto; Et Al
参考文献:Organic Letters 日期:2006 卷标:8(17) 页码:3805-3808]

13466-38-1 + 667-27-6 = 899452-26-7 + 832735-61-2 + 1072-97-5
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; Rt -> Reflux; 1.5 H,Reflux
标题:Facile One-Pot Synthesis Of N-Difluoromethyl-2-Pyridone Derivatives
作者:Ando,Makoto; Et Al
参考文献:Organic Letters 日期:2006 卷标:8(17) 页码:3805-3808

📜2-羟基-5-溴吡啶,2-氟磺酰基二氟乙酸置于sodium Sulfate体系中,用乙腈作为反应溶剂,化学反应 4.5H,以77%的收率获得产物2-(二氟甲氧基)-5-溴吡啶
参考文献:Facile One-Pot Synthesis Of N-Difluoromethyl-2-Pyridone Derivatives
标题:Facile One-Pot Synthesis Of N-Difluoromethyl-2-Pyridone Derivatives
摘要:A Novel One-Pot Synthesis Of N-Difluoromethyl-2-Pyridones Is Described. N-(Pyridin-2-yl) Acetamide Derivatives Were Excellent Precursors For The Preparation Of N-Difluoromethyl-2-Pyridone Derivatives. Difluoromethylation Of 2-Acetaminopyridine Derivatives Was Achieved With Sodium Chlorodifluoroacetate As A Difluorocarbene Source In The Presence Of A Catalytic Amount Of 18-Crown-6. Subsequent In Situ Hydrolysis Of Resultant 1,2-Dihydro-2-Acetimino-1-Difluoromethylpyridines Proceeded Under Mild Acidic Conditions To Afford The Corresponding N-Difluoromethyl-2-Pyridones In Moderate To Good Yields.
DOI:10.1021/ol061481F