CAS: 873-83-6; 6-Aminopyrimidine-2,4(1H,3H)-Dione

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186435-66-5 3240-72-0 100643-27-4

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CAS号105-56-6 氰乙酸乙酯 | CAS号57-13-6 尿素 | CAS号1448-98-2 氰乙酰脲 | CAS号1004-40-6 6-氨基-2-巯基嘧啶-4-醇 | CAS号591-07-1 乙酰脲 | CAS号52386-29-5 6-氨基-2-甲氧基-4-嘧啶酮 | CAS号69-93-2 尿酸 | CAS号372-09-8 氰基乙酸 | CAS号79-04-9 氯乙酰氯 | CAS号4270-27-3 6-氯尿嘧啶 | CAS号5442-24-0 4-氨基-2,6-二羟基-5-亚硝基嘧啶 | CAS号3346-22-3 6-氨基-5-硝基嘧啶-2,4... | CAS号39929-79-8 2,4-二羟基吡咯[2,3-d]嘧啶 | CAS号21333-02-8 6-[(4-chlorophe... | CAS号66-22-8 尿嘧啶 | CAS号29817-67-2 Benzenesulfonam... | CAS号30161-91-2 2-氨基-噻唑并[4,5-d]... | CAS号2434-53-9 6-氨基-1-甲基脲嘧啶 | CAS号67-52-7 巴比妥酸 | CAS号27402-47-7 5-苯亚甲基巴比土酸

尿酸置于乙二胺四乙酸,氧化亚氮体系中,用 Phosphate Buffer 作为反应溶剂,化学反应生成 4-氨基-2,6-二羟基嘧啶
参考文献:Inactivation Of Nitric Oxide By Uric Acid
标题:Inactivation Of Nitric Oxide By Uric Acid
摘要:The 1980 Identification Of Nitric Oxide (No) As An Endothelial Cell-Derived Relaxing Factor Resulted In An Unprecedented Biomedical Research Of No And Established No As One Of The Most Important Cardiovascular,Nervous And Immune System Regulatory Molecule. A Reduction In Endothelial Cell No Levels Leading To Endothelial Dysfunction Has Been Identified As A Key Pathogenic Event Preceding The Development Of Hypertension,Metabolic Syndrome,And Cardiovascular Disease. The Reduction In Endothelial No In Cardiovascular Disease Has Been Attributed To The Action Of Oxidants That Either Directly React With No Or Uncouple Its Substrate Enzyme. In This Report,We Demonstrate That Uric Acid (Ua),The Most Abundant Antioxidant In Plasma,Reacts Directly With No In A Rapid Irreversible Reaction Resulting In The Formation Of 6-Aminouracil And Depletion Of No. We Further Show That This Reaction occurs Preferentially With No Even In The Presence Of Oxidants Peroxynitrite And Hydrogen Peroxide And That The Reaction Is At Least Partially Blocked By Glutathione. This Study Shows A Potential Mechanism By Which Ua May Deplete No And Cause Endothelial Dysfunction,Particularly Under Conditions Of Oxidative Stress In Which Ua Is Elevated And Intracellular Glutathione Is Depleted.
DOI:10.1080/15257770802257952

专利信息

专利号:US-9221821-B2
优先权日:2012-06-05
标题:Methods for the synthesis of 1,3-substituted aminouracils and other xanthine-related compounds
发明人：DIEP NHUT; KALYAN YURIY B
权利人:FOREST LAB HOLDINGS LTD; FOREST LAB HOLDINGS LTD
摘要:Methods for the synthesis of disubstituted aminouracils and xanthine and/or xanthine-related compounds are provided.

专利号:US-4849513-A
优先权日:1983-12-20
标 题 :Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-5118802-A
优先权日:1983-12-20
标 题:DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-5118800-A
优先权日:1983-12-20
标 题 :Oligonucleotides possessing a primary amino group in the terminal nucleotide
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-8501941-B2
优先权日:2005-02-25
标题 :Methods for the synthesis of unsymmetrical cycloakyl substituted xanthines
发明人：WANG GUOQUAN; RIEGER JAYSON M; THOMPSON ROBERT D
权利人:WANG GUOQUAN; RIEGER JAYSON M; THOMPSON ROBERT D; DOGWOOD PHARMACEUTICALS INC
摘要:The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents. Also provided are processes for the preparation of the compounds and their intermediates.

专利号:US-5015733-A
优先权日:1983-12-20
标题 :Nucleosides possessing blocked aliphatic amino groups
发明人：SMITH LLOYD M; FUND STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieites may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.