CAS: 828254-17-7; (R,S)-2-Isobutyl-3-(Boc-Amino)Propanoic Acid

该化合物是一种在丙二酸合成和药用化学中广泛使用的保护性氨基酸衍生物,其存在确保有选择地保护矿物质功能,使在温和酸条件下有控制的去保护成为可能,该化合物因其结构多功能性及其与固态聚二苯醚合成技术的兼容性,在合成复杂的丙二烯和聚四胺合成技术方面特别宝贵,其异丁基副产品链有助于在丙三烯设计中进行疏水相互作用,而乙二氧基碳基(Boc)组则提高有机溶剂的溶性,种族形式允许立体化学应用的灵活性,使其成为制药研究和不对称合成的有用中间体.

结构式图片

相似化合物

132605-96-0 132605-95-9 1018899-99-4

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate (2R)-([amino]methyl)-4-methylpentanoic acid (2S)-N-{(2R)-2-[(dibenzylamino)methyl]-4-methylpentanoyl}camphorsultam (S)-N-(2-bromo-4-methyl-pentanoyl) camphorsultam

合成工艺路线路线简述

  • 14477-72-6 + 100299-50-1 + 114438-66-3 = 828254-17-7
    反应条件:1.1 Reagents: Zinc Catalysts: 1,2-Dibromoethane Solvents: Dimethoxymethane; Reflux1.2 15 Min,Rt1.3 1.5 H,Rt1.4 Reagents: Ammonium Chloride Solvents: Water; Rt1.5 Reagents: Trifluoroacetic Acid Solvents: Ethylamine; Rt2.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: Methanol,Tetrahydrofuran; Rt2.2 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 1 - 3 H,Rt2.3 Reagents: Potassium Carbonate Solvents: 1,4-Dioxane; 5 H,Rt2.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,0 °C
    标题:Efficient Synthesis Of β2-Amino Acid By Homologation Of α-Amino Acids Involving The Reformatsky Reaction And Mannich-Type Iminium Electrophile
    作者:Moumne,Roba; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2006 卷标:71(8) 页码:3332-3334]

    28659-87-2 = 828254-17-7
    反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Methanol; 1 H,Reflux2.1 Reagents: Zinc Catalysts: 1,2-Dibromoethane Solvents: Dimethoxymethane; Reflux2.2 15 Min,Rt2.3 1.5 H,Rt2.4 Reagents: Ammonium Chloride Solvents: Water; Rt2.5 Reagents: Trifluoroacetic Acid Solvents: Ethylamine; Rt3.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: Methanol,Tetrahydrofuran; Rt3.2 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 1 - 3 H,Rt3.3 Reagents: Potassium Carbonate Solvents: 1,4-Dioxane; 5 H,Rt3.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,0 °C
    标题:Efficient Synthesis Of β2-Amino Acid By Homologation Of α-Amino Acids Involving The Reformatsky Reaction And Mannich-Type Iminium Electrophile
    作者:Moumne,Roba; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2006 卷标:71(8) 页码:3332-3334]

    61-90-5 = 828254-17-7
    反应条件:1.1 Reagents: Sodium Nitrite,Sodium Bromide,Sulfuric Acid Solvents: Water; 1 H,0 °C; 0 °C -> Rt; 6 H,Rt2.1 Catalysts: Sulfuric Acid Solvents: Methanol; 1 H,Reflux3.1 Reagents: Zinc Catalysts: 1,2-Dibromoethane Solvents: Dimethoxymethane; Reflux3.2 15 Min,Rt3.3 1.5 H,Rt3.4 Reagents: Ammonium Chloride Solvents: Water; Rt3.5 Reagents: Trifluoroacetic Acid Solvents: Ethylamine; Rt4.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: Methanol,Tetrahydrofuran; Rt4.2 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 1 - 3 H,Rt4.3 Reagents: Potassium Carbonate Solvents: 1,4-Dioxane; 5 H,Rt4.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,0 °C
    标题:Efficient Synthesis Of β2-Amino Acid By Homologation Of α-Amino Acids Involving The Reformatsky Reaction And Mannich-Type Iminium Electrophile
    作者:Moumne,Roba; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2006 卷标:71(8) 页码:3332-3334]

    = 828254-17-7
    反应条件:1.1 Catalysts: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 40 Min,100 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Beta Amino Acid-Modified And Fluorescently Labeled Kisspeptin Analogues With Potent Kiss1R Activity
    作者:Camerino,M. A.; Et Al
    参考文献:Journal Of Peptide Science 日期:2016 卷标:22(6) 页码:406-414]

    24424-99-5 = 828254-17-7
    反应条件:1.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: Methanol,Tetrahydrofuran; Rt1.2 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 1 - 3 H,Rt1.3 Reagents: Potassium Carbonate Solvents: 1,4-Dioxane; 5 H,Rt1.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,0 °C
    标题:Efficient Synthesis Of β2-Amino Acid By Homologation Of α-Amino Acids Involving The Reformatsky Reaction And Mannich-Type Iminium Electrophile
    作者:Moumne,Roba; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2006 卷标:71(8) 页码:3332-3334]

    24424-99-5 + 106367-47-9 = 828254-17-7
    反应条件:1.1 Reagents: Cobalt Chloride (Cocl2),Sodium Borohydride Solvents: Methanol; Rt -> 0 °C; 2 H,0 °C; 0 °C -> Rt; 16 - 24 H,Rt1.2 Reagents: Diethylenetriamine; 30 Min,Rt2.1 Catalysts: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 40 Min,100 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Beta Amino Acid-Modified And Fluorescently Labeled Kisspeptin Analogues With Potent Kiss1R Activity
    作者:Camerino,M. A.; Et Al
    参考文献:Journal Of Peptide Science 日期:2016 卷标:22(6) 页码:406-414]

    105-34-0 = 828254-17-7
    反应条件:1.1 Catalysts: Piperidine Solvents: Methanol; 16 H,Reflux2.1 Reagents: Cobalt Chloride (Cocl2),Sodium Borohydride Solvents: Methanol; Rt -> 0 °C; 2 H,0 °C; 0 °C -> Rt; 16 - 24 H,Rt2.2 Reagents: Diethylenetriamine; 30 Min,Rt3.1 Catalysts: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 40 Min,100 °C3.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Beta Amino Acid-Modified And Fluorescently Labeled Kisspeptin Analogues With Potent Kiss1R Activity
    作者:Camerino,M. A.; Et Al
    参考文献:Journal Of Peptide Science 日期:2016 卷标:22(6) 页码:406-414

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参考DOI号:10.1002/psc.2883
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