CAS: 60129-59-1; (2R,3S,5R)-5-(4-Amino-7H-Pyrrolo[2,3-D]Pyrimidin-7-yl)-2-(Hydroxymethyl)Tetrahydrofuran-3-Ol

相似化合物

69-33-0 166247-63-8 908130-61-0

上下游产品

CAS号4330-21-6 1-Α-氯-3,5-二-O-对... | CAS号86402-13-3 4-Amino-7-(2-de... | CAS号90213-66-4 2,4-二氯-7H吡咯[2,3-D]嘧啶 | CAS号39929-79-8 2,4-二羟基吡咯[2,3-d]嘧啶 | CAS号57564-94-0 4-氯-2-(甲硫基)-7H-... | CAS号1500-85-2 4-氨基-7H-吡咯[2,3-d]嘧啶 | CAS号90335-57-2 n4-benzoyl-5'-o... | CAS号95261-09-9 N4-BENZOYL-7-DE...

📜4-Amino-7-(2-Desoxy-β-D-Erythro-Pentofuranosyl)-2-Methylthio-7H-Pyrrolo(2,3-D)Pyrimidin置于镍体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应 2.0H,以67%的收率获得产物(2R,3S,5R)-5-(4-氨基-7H-吡咯[2,3-D]嘧啶-7-基-2-(羟甲基)四氢呋喃-3-醇
参考文献:2'-Deoxytubercidin-通过相转移糖基化合成2'-脱氧腺苷等位基因
标题:2'-Deoxytubercidin-通过相转移糖基化合成2'-脱氧腺苷等位基因
摘要:2'-Deoxytubercidin(1),一个2'-Deoxyadenosine(2)的等排物,是通过生色团3A与甲苯酰保护的卤化6的相转移糖基化反应绕过天然前体制备的.在糖基化过程中仅形成β-异头物.碱水解5A的保护基后,获得2'-脱氧-2-(甲硫基)结核菌素(5B),将其用阮内镍脱硫后得到标题化合物1.糖基化位置n-7可以借助13 C,C-6和1'-H之间的1 H-NMR远程偶联来确定.
DOI:10.1002/jlac.198319830513

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-2020239500-A1
优先权日:2018-04-04
标 题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:EP-0604552-A4
优先权日:1991-09-18
标 题:PROCESS FOR THE SYNTHESIS OF VARIOUS COLLECTIONS OF OLIGOMERS.

专利号:US-2021332070-A1
优先权日:2018-04-04
标题:Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-11021497-B2
优先权日:2018-04-04
标题 :Compositions and methods for synthesis of phosphorylated molecules

专利号:US-6165778-A
优先权日:1993-11-02
标 题 :Reaction vessel agitation apparatus
发明人：KEDAR HAIM
权利人:AFFYMAX TECH NV
摘要:A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel 200 contains a suspension of substrates. The suspension is pressurized with argon and transferred to a plurality of reaction vessels 201-209 in one or more reaction vessel banks where monomer addition reactions take place. Optionally, the substrates may be tagged with a tag monomer. A vortexing motor 300 vortexes the contents of reaction vessels 201-209 during monomer addition reactions to enhance synthesis. After the desired monomer and/or tag monomer addition reaction, the suspension is pressurized with argon and transferred back to parent vessel 200 for mixing. Thereafter, the suspension may be pressurized with argon and reallocated among reaction vessels 201-209 for further synthesis.