CAS: 53145-38-3; 2-Chloro-6-Fluoroanisole

上下游产品

CAS号2040-90-6 2-氯-6-氟苯酚 | CAS号74-88-4 碘甲烷 | CAS号2040-90-6 2-氯-6-氟苯酚 | CAS号944129-07-1 4-氯-2-氟-3-甲氧基苯硼酸

2,3-二氯硝基苯置于盐酸,1% Platinum On Charcoal,氢气,二异丙胺体系中,用 甲醇,水,甲苯 作为反应溶剂,60.0 °C,450.01 Kpa 条件下,反应 26.5H,反应生成 2-氯-6-氟苯甲醚
参考文献:一种2-氯-6-氟苯甲醚及其中间体的制备方法
标题:一种2-氯-6-氟苯甲醚及其中间体的制备方法
摘要:本发明公开了一种2-氯-6-氟苯甲醚及其中间体的制备方法.本发明公开的2-氯-6-氟苯甲醚的制备方法,包含下列步骤:在100~150oc的条件下,将如式v所示的化合物进行裂解反应.本发明公开的如式iii所示的化合物的制备方法,包含下列步骤:溶剂中,在铂碳的催化下,将如式ii所示的化合物与氢气进行还原反应,制得如式iii所示的化合物.本发明公开的如式ii所示的化合物的制备方法,包含下列步骤:溶剂中,在催化剂的作用下,将如式i所示的化合物与甲醇钠进行如下所示的醚化反应,制得如式ii所示的化合物.本发明的制备方法原料廉价易得,生产成本低,反应条件温和,收率高以及更适用于工业化生产.

专利信息

专利号:US-10570114-B2
优先权日:2016-05-19
标题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling
发明人：FISK JASON S; LI XIAOYONG; Muehlfeld Mark; BAUMAN ROBERT S; OPPENHEIMER JOSSIAN; TU SIYU; NITZ MARK A; CHAKRABARTI REETAM; FEIST SHAWN D; RINGER JAMES W; LENG RONALD B
权利人:DOW AGROSCIENCES LLC
摘要:Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.

专利号:US-2018334444-A1
优先权日:2016-05-19
标 题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling

专利号:US-2018334445-A1
优先权日:2016-05-19
标题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling

专利号:EP-3458442-A1
优先权日:2016-05-19
标 题 :Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling

专利号:US-10087164-B2
优先权日:2016-05-19
标 题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct Suzuki coupling

专利号:US-10544121-B2
优先权日:2016-05-19
标 题 :Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling