CAS: 49808-20-0; 6,6Dithiobispurine
该化合物是含有硫醇的硫磺酸六甲基苯丙胺的角衍生物,其特征为脱硫联系,它比单一美化形式更加稳定且更能调节反应.它作为药物合成的辅助剂或中间体,特别是在抗代谢疗法中.脱硫联系允许在减少条件下有控制地释放活性硫醇物种,使其对有针对性的药物运载系统具有价值.它的应用扩大到肿瘤学和免疫学研究,它有助于研究纯代谢和细胞毒性机制.该化合物在环境条件下的稳定性和可预测的红毒行为是实验室和工业使用的关键技术优势.
- 英文名称6,6Dithiobispurine
- 中文名称6,6二硫代双嘌呤
- IUPAC名称6,6Dithiobispurine
- 其它别名6,6Dithiobispurine; Azathioprine Impurity C; 6-(7H-Purin-6-Yldisulfanyl)-7H-Purine; Mercaptopurine Impurity 2; 9H-Purine, 6,6'-Dithiodi-; Mercaptopurine Impurity 2 (Mercaptopurine Ep Impurity D); 6,6′-Dithiodi-9H-Purine; 1,2-Di(7H-Purin-6-yl)Disulfane
- CAS编号49808-20-0
- EINECS号:691-233-2
- FDA UNII编号:4Z5Q8TY5GI
- 分子式:C10H6N8S2分子量:302.35
- 产品CID: 1485014
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
6-Mercaptopurine 6H-purine-6-thione合成工艺路线路线简述
📜6-Mercaptopurine置于碘,Potassium Iodide体系中,用 Phosphate Buffer 作为反应溶剂,以41%的收率获得产物6,6二硫代双嘌呤
参考文献:Pazderski; Tousek; Sitkowski,Polish Journal Of Chemistry,2007,Vol. 81,# 2,P. 193-210
标题:Pazderski; Tousek; Sitkowski,Polish Journal Of Chemistry,2007,Vol. 81,# 2,P. 193-210
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of Bis(7-Methyl-2- Or 6-Purinyl) Disulfides作者:Alicja Kowalska |发布日期:2007.10.18
摘要:Substituted 7-Methyl-2- Or 6-Purinethiones Were Obtained In Series Of Reactions By Nucleophilic Substitution With Oxygen, Chloro, And Sulfur Nucleophiles. Oxidation Of The Sulfur Atom At Position 6 Or 2 In Purinethiones To Corresponding Disulfides Depended On The Conditions Of The Reaction And Oxidizing Agent.
合成参考文献
参考文献:10.1016/j.bbrc.2023.08.050
摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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