CAS: 49561-96-8; 4-(Trifluoromethoxy)Phenylacetonitrile

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CAS号773837-37-9 sodium cyanide | CAS号50824-05-0 对三氟甲氧基溴苄 | CAS号151-50-8 氰化钾 | CAS号1736-74-9 4-(三氟甲氧基)苄醇 | CAS号587-18-8 4-(三氟甲氧基)苯甲酸乙酯 | CAS号4315-07-5 4-(三氟甲氧基)苯基乙酸 | CAS号170015-99-3 4-三氟甲氧基苯乙胺 | CAS号936727-93-4 1-(4-Trifluorom...

4-三氟甲氧基溴苄 以 乙醇,水 作为反应溶剂,以76.3%的收率获得产物4-(三氟甲氧基)苯基乙腈
参考文献:Process For Preparing 2-(4-Trifluoromethoxyphenyl)Ethylamine And 4-Bromomethyl-And 4-Chloromethyl-1-Trifluoromethoxybenzene
标题:Process For Preparing 2-(4-Trifluoromethoxyphenyl)Ethylamine And 4-Bromomethyl-And 4-Chloromethyl-1-Trifluoromethoxybenzene
摘要:该发明涉及一种制备2-(4-三氟甲氧基苯基)乙胺的方法,通过以下步骤实现:(A) 将三氟甲氧基苯转化为卤甲基化合物,得到卤代甲基-1-三氟甲氧基苯;(B) 将卤代甲基-1-三氟甲氧基苯通过卤-氰交换反应转化为4-(三氟甲氧基苯基)乙腈;(C) 在镍催化剂存在下,使用氢气还原4-(三氟甲氧基苯基)乙腈,得到2-(4-三氟甲氧基苯基)乙胺.该方法的第一步也是制备4-溴甲基和4-氯甲基-1-三氟甲氧基苯的优势方法.

专利信息

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:WO-2021078995-A1
优先权日:2019-10-25
标 题 :Selective polypeptide synthesis stalling assay and compound
发明人：STROUS GERARDUS JACOBUS ANTONIUS MARIA; MOL JAN ADRIANUS; VAN DER VELDEN LIEKE MARIE; KLUMPERMAN JUDITH; MAAS PETRUS EMMANUEL MARIE; PIET DENNIS PATRICK; DE KLERK-SPRENKELS NANDA ELISABETH; TIJHUIS JOHANN HEINRICH; VIÉTOR HENDRIK ENGELBERTUS; MAURICE MADELON MARIA; VAN DER KRIFT FELIX
权利人:UMC UTRECHT HOLDING BV; UNIV UTRECHT HOLDING BV; BIMINI BIOTECH B V
摘要:The invention relates to compounds, in particular pyrimidine-2,4-diamines, analogues and salts thereof and pharmaceutical compositions comprising pyrimidine-2,4-diamines analogues and salts thereof for use in the treatment and prevention of a disease, in particular a growth hormone receptor-dependent condition. The invention also relates to methods of using these compounds and compositions to treat physiological disorders related to the amount or activity of growth hormone. In a particular embodiment, the invention relates to a compound according to formula 1 for use in the treatment or prevention of a disease in a subject.

专利号:US-7777060-B2
优先权日:2007-02-14
标题:Platinum analogs with bis-nitrile-containing ligands
发明人：CHEN XINGHAI; PETLURU PAVANKUMAR N V; HUANG QIULI; NARKUNAN KESAVARAM; HAUSHEER FREDERICK
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as quantitative in vitro IC50 data.

专利号:RU-2122999-C1
优先权日:1991-12-23
标 题:Tetrahydroisoquinoline compounds or their pharmaceutically acceptable salts, method of their synthesis, pharmaceutical composition based on thereof and method of dophamine receptor binding