CAS: 4383-07-7; 2-(Hydroxymethyl)-4-Methylphenol

上下游产品

formaldehyd p-cresol 6-Chlor-2-hydroxymethyl-4-methylphenol 2-bromo-6-(hydroxymethyl)-4-methyl-phenol 2-(2-hydroxymethyl-4-methyl-phenoxymethyl)-5-methoxy-pyran-4-one 2-hydroxy-5-methylazobenzene 2-hydroxy-5-methylbenzaldehyde 2-hydroxy-5-methyl-3-nitrobenzenemethanol

📜5-甲基水杨酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 2-羟基-5-甲基苄醇
参考文献:协同手性伯胺/钯催化的不对称retro-Claisen反应.
标题:协同手性伯胺/钯催化的不对称retro-Claisen反应.
摘要:我们在本文中描述了β-二酮与水杨酸盐碳酸酯的手性伯胺/钯催化的不对称逆克莱森反应.通过一系列脱羧苄基化,逆克莱森裂解和烯胺质子化反应,获得了一系列具有非常好收率和优异对映选择性的手性α-烷基化酮和大环内酯.该策略具有广泛的底物范围,温和的条件以及以水杨酸碳酸酯为邻醌甲基化物前体的高原子经济性.
DOI:10.1021/acs.Orglett.9B02491

专利信息

专利号:US-2009221568-A1
优先权日:2005-11-04
标题:Synthesis of Inhibitors of FtsZ
发明人：SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
权利人:SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
摘要:FtsZ, the bacterial analog of tubulin, is a promising new target for developing new antibiotics. It has been shown that polyphenols inhibit the GTPase activity of FtsZ, thereby inhibiting Z-ring formation during mitosis. The present invention provides novel polyphenols compounds, which can be accessed by the synthesis of dichamametin and 2′″-hydroxy-5″-benzylisouvarinol-B as described herein. These novel compounds are useful in treating infections, particularly infections caused by gram-positive organisms. Methods of preparing the inventive compounds are also provided. The compounds are prepared by the benzylation of pinocembrin or chrysin core structure. Pharmaceutical compositions and method of using the compounds to treat disease are also provided. These compounds may be screened for antimicrobial activity as well as other biological activities such as anti-neoplastic, anti-inflammatory, immunosuppressive, and cytotoxic activity.

专利号:WO-2023097678-A1
优先权日:2021-12-03
标 题:Method for synthesizing (r)-5-(2,2-dimethyl-4h-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one
发明人：ZHOU ZHANGTAO; YE WEIPING; PHILLIS ANDREW TOROA; XU LI; HUANG ZHINING; FU LI
权利人:GUANGDONG RAFFLES PHARMATECH CO LTD
摘要:A method for synthesizing (R)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one. The synthesis route of the method is: where X is Br, Cl or I, preferably Br. Preferably, chiral phenyloxazolidin-2-one is prepared from a 2-bromoacetophenone compound in a high-selectivity manner by means of protection, nucleophilic attack, asymmetric transfer hydrogenation, and finally CDI ring closing.