CAS: 4295-04-9; 4-Chloro-6-Methoxyquinoline

相似化合物

70049-46-6 103862-63-1 148018-29-5

上下游产品

CAS号23432-39-5 4-肼基-6-甲氧基喹啉 | CAS号13788-72-2 6-甲氧基喹啉-4-酮 | CAS号6563-13-9 6-甲氧基喹啉N-氧化物 | CAS号124-41-4 甲醇钠 | CAS号703-61-7 2,4-二氯喹啉 | CAS号104-94-9 对甲氧基苯胺 | CAS号83507-70-4 2-((4-甲氧基苯基氨基)亚... | CAS号91092-95-4 4-羟基-6-甲氧基喹啉-2-羧酸 | CAS号66003-25-6 ethyl 6-methoxy... | CAS号28027-16-9 4-羟基-6-甲氧基喹啉-3-羧酸 | CAS号3517-61-1 4,6-二羟基喹啉 | CAS号23432-39-5 4-肼基-6-甲氧基喹啉 | CAS号6279-51-2 4-氨基-6-甲氧基喹啉 | CAS号148018-29-5 4-氯-6-羟基喹啉 | CAS号112590-52-0 4-chloro-1-hydr... | CAS号4295-45-8 2-methoxy-11H-i... | CAS号50593-72-1 4-Chloro-6-meth... | CAS号5450-23-7 2-(6-methoxyqui... | CAS号38925-92-7 N',N'-bis(2-chl...

📜4-羟基-6-甲氧基喹啉-3-羧酸乙酯置于盐酸,Ammonium Hydroxide,Sodium Hydroxide,三氯氧磷体系中,用 甲醇 作为反应溶剂,化学反应生成 4-氯-6-甲氧基喹啉
参考文献:关于双电荷四氮杂环烷作为小电导ca 2+激活的k +通道的强抑制剂的进一步研究
标题:关于双电荷四氮杂环烷作为小电导ca 2+激活的k +通道的强抑制剂的进一步研究
摘要:以前,已证明基于喹啉鎓的四氮杂环烷酮(例如ucl 1684和ucl 1848)作为有效的小肽非肽类阻滞剂,对化学结构的变化(尤其是对环庚烷体系的大小)非常敏感.电导ca 2+激活的k +离子通道(sk Ca).当前的工作试图优化ucl 1848中连接链的结构.我们报道了29个ucl 1848类似物的合成和sk Ca通道阻滞活性,其中ucl 1848的中心ch 2被其他基团x或取代. Y = O,S,Cf 2,C O,Choh,C C,Chch,Chme,以探索键长或柔韧性的细微变化是否可以进一步提高效力.通过合成和测试带有取代基(no 2,Nh 2,Cf 3,F,Cl,Ch 3,och 3,ocf 3,Oh)在氨基喹啉鎓环的5,6或7个位置上.与我们之前的工作一样,测定了每种化合物对大鼠交感神经元后超极化(ahp)的抑制作用,这种作用是由sk Ca通道的sk3亚型介导的.一种新化合物(39,R
DOI:10.1016/j.Ejmech.2013.02.029

专利信息

专利号:US-3989691-A
优先权日:1973-01-05
标 题 :Preparation of cinchona alkaloid intermediates
发明人：TAYLOR EDWARD C; MARTIN STEPHEN F
权利人:UNIV PRINCETON
摘要:4-[3-(3-vinyl-1-acetyl-4-piperidyl)-1-propenyl]-6-methoxyquinoline, the corresponding epoxide and related compounds, useful in the synthesis of Cinchona alkaloids, are prepared by introducing an ylid group in the 4-position of a suitably substituted quinoline and reacting this ylid with an N-acetyl-4-piperidineacetaldehyde.

专利号:US-2012122923-A1
优先权日:2006-06-13
标 题:Dual molecules containing a peroxide derivative, their synthesis and therapeutic uses
发明人：COSLEDAN FREDERIC; MEUNIER BERNARD; PELLET ALAIN
权利人:COSLEDAN FREDERIC; MEUNIER BERNARD; PELLET ALAIN; SANOFI AVENTIS; PALUMED SA; CENTRE NAT RECH SCIENT
摘要:The invention concerns dual molecules corresponding to formula (I): in which: A represents a molecular residue with antimalarial activity of formula (IIa) or (IIIa) or a residue facilitating bioavailability; B represents a cycloalkyl group potentially substituted, or B represents a bi- or tricyclic group capable of being substituted, or B represents 2 cycloalkyl groups linked together through either a single bond or an alkylene chain; m and n represent independently of one another 0, 1 or 2; R 5 represents a hydrogen atom, an alkyl, cycloalkyl or C 1-3 -alkylene-cycloakyl group; Z 1 and Z 2 represent an alkyl radical, the group Z 1 +Z 2 +C i +C j representing a mono- or polycyclic structure, with one of the Z 1 or Z 2 being able to represent a single bond; R 1 and R 2 , identical or different, represent a hydrogen atom or a functional group capable of increasing hydrosolubility; R x and R y forming together a cyclic peroxide including 4 to 8 links and including 1 or 2 additional oxygen atoms in the cyclic structure, possibly substituted by one or more R 3 groups; as a base or a salt to be added to an acid, as a hydrate or solvate, in racemic form, isomers and their mixtures, in addition to their diasteroisomers and their mixtures. Preparation method and use as medications with antimalarial activity.

专利号:HU-P0401607-A2
优先权日:2004-08-10
标题 :Synthesis of aminoquinoline derivatives and of their starting materials

专利号:EP-1695964-A1
优先权日:2000-11-15
标题 :Quinoline derivatives for use as intermediates in the synthesis of heterocyclylalcoyl piperidines

专利号:CN-114250479-B
优先权日:2021-12-11
标 题 :A new method for the synthesis of alkyl-substituted nitrogen-containing heterocycles catalyzed by cerium salts