CAS: 33640-67-4; (2S,3R)-Benzyl 2-Amino-3-Hydroxybutanoate

该化合物是氨基酸L-threonine的酯衍生物,其特征是存在一个骨干骨干,这是蛋白合成中必不可少的氨基硫酸,以及一个加强亲脂性的苯基甲基(苯基)组,该化合物一般是白色到白色的晶状固体,在有机溶剂中可溶解,而其在水中的溶解性可能不同.该酯功能组的存在有助于其再活动,使其在各种化学反应中有用,包括peptide合成.L-Treoninine本身在代谢工艺中发挥着关键作用,对于蛋白和其他生物分子的生产非常重要.L-3-threnine的化可以改变其特性,有可能影响其生物活动以及药物或生物化学应用.与许多氨基油衍生物一样,它可能表现出特定的光学活动,其原因是马氏细胞的特性.

结构式图片

相似化合物

33645-24-8 82679-58-1 16597-50-5

物理性质

MSDS等安全信息

    上下游产品

    N-(tert-butyloxycarbonyl)-threonine benzyl ester L-threonine benzyl alcohol 18H21NO5SC18H21NO5S(2S,3R)-2-Formylamino-3-hydroxy-butyric acid benzyl ester benzyl N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)-L-threonyl-L-threoninate benzyl N-(benzyloxycarbonyl)-O-(2,3,4,6-tetra-O-benzyl-α-D-galactopyranosyl)-L-threonyl-L-threoninate B°C-Leu-Pro-Thr-OBzl

    合成工艺路线路线简述

    • 合成目标产物 L-Threonine Benzyl Ester 主要起始原料 L-Threonine And Benzyl Alcohol
    • (文献来源)合成步骤主要原料 L-Threonine 和 Benzyl Alcohol
    📜N-(Tert-Butyloxycarbonyl)-Threonine Benzyl Ester置于盐酸体系中,化学反应生成 L-苏氨酸苯甲酯
    参考文献:Schnabel,E. Et Al.,Justus Liebigs Annalen Der Chemie,1971,Vol. 749,P. 90-108
    标题:Schnabel,E. Et Al.,Justus Liebigs Annalen Der Chemie,1971,Vol. 749,P. 90-108

    海关参考信息

    专利信息


    专利号:US-5175266-A
    优先权日:1991-04-19
    标 题 :Nucleosides and oligonucleosides with a phosphate-free internucleoside backbone and process for preparing the same
    发明人：VARMA RAJENDER S; HOGAN MICHAEL E; REVANKAR GANAPATHI R; RAO TAKKELLAPATI S
    权利人:TRIPLEX PHARMA CORP; BAYLOR COLLEGE MEDICINE
    摘要:Nucleoside derivatives which contain a nucleo-base, a sugar and an amino acid backbone of the structure: ##STR1## where R' refers to the various amino acid side chains or their blocked equivalent and R refers to a nucleo-base or its blocked equivalent. The synthesis of these nucleoside derivatives proceeds by a series of steps including oxidation of the 3'-azido nucleoside derivative, coupling to a benzylated ester of an amino acid to yield the amide and hydrogenation. The adenine, guanine, cytosine and thymine nucleosides with an amino acid at the 5' terminus are synthesized. From such monomers oligonucleotides can be synthesized which possess an amino acid backbone, using either solid state phase chemistry or liquid phase chemistry.

    专利号:CN-104098650-B
    优先权日:2013-04-15
    标题 :The synthesis and application of the intermediate of Atosiban

    专利号:CN-101597322-B
    优先权日:2008-06-06
    标 题:17 Analogues of Tyr-Ile-Gly-Ser-Arg, Their Synthesis and Application in Medicine

    专利号:CN-102241674-A
    优先权日:2010-05-12
    标题 :Synthesis and Antitumor Activity Evaluation of 1,1-Dimethyl-β-carboline-3-formyl Amino Acid Benzyl Ester

    专利号:CN-117586336-A
    优先权日:2023-11-14
    标题 :Synthesis method and application of difficult polypeptide

    专利号:CN-102241674-B
    优先权日:2010-05-12
    标 题 :Synthesis and Antitumor Activity Evaluation of 1,1-Dimethyl-β-carboline-3-formyl Amino Acid Benzyl Ester

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    合成参考文献


    摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 222.
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