CAS: 328086-60-8; (S)-Methyl 2-((Tert-Butoxycarbonyl)Amino)-3-((S)-2-Oxopyrrolidin-3-yl)Propanoate

上下游产品

(2S,4S)-2-(2-Amino-ethyl)-4-tert-butoxycarbonylamino-pentanedioic acid dimethyl ester L-glutamic acid L-glutamic acid dimethyl ester dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate [2-hydroxy-1S-(2-oxopyrrolidin-3S-ylmethyl)ethyl]carbamic acid tert-butyl ester (S)-2-{(S)-2-[(2S,3R)-2-((S)-2-Acetylamino-3-methyl-butyrylamino)-3-benzyloxy-butyrylamino]-4-methyl-pentanoylamino}-3-((S)-2-oxo-pyrrolidin-3-yl)-propionic acid methyl ester (2S,5S,8S,11S)-8-((R)-1-(benzyloxy)ethyl)-5-isobutyl-11-isopropyl-4,7,10,13-tetraoxo-2-((S)-2-oxopyrrolidin-3-yl)methyl-3,6,9,12-tetraazatetradecan-1-oic acid methyl (2S)-2-[[(2S)-2-amino-3-cyclohexyl-propanoyl]amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propanoate

L-谷氨酸置于platinum(Iv) Oxide,三甲基氯硅烷,氢气,Sodium Acetate,Lithium Hexamethyldisilazane体系中,用 四氢呋喃,甲醇,氯仿 用作溶剂,化学反应 28.0H,反应生成(Alphas,3S)-Alpha-[(叔-丁基氧羰基)氨基]-2-氧代-3-吡咯烷丙酸甲酯
参考文献:Improved Synthesis Of Rupintrivir
标题:Improved Synthesis Of Rupintrivir
摘要:对rupintrivir (Ag7088) 的改进合成使用了三种氨基酸(l-谷氨酸,D-4-氟苯丙氨酸和l-缬氨酸)作为构建块.关键片段酮亚甲基二肽异构体通过缬氨酸衍生物和苯丙酸衍生物的构建而成,随后与内酰胺衍生物和异恶唑酸氯化物偶联,最终在八个步骤中合成出ag7088.
Doi:10.1007/s11426-011-4478-5

专利信息

专利号:WO-2005113580-A1
优先权日:2004-05-21
标题 :Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis
发明人：HOFFMAN ROBERT LOUIS; KANIA ROBERT STEVEN; NIEMAN JAMES ANDREW; PLANKEN SIMON PAUL; SMITH GEORGE JOSEPH III
权利人:PFIZER; HOFFMAN ROBERT LOUIS; KANIA ROBERT STEVEN; NIEMAN JAMES ANDREW; PLANKEN SIMON PAUL; SMITH GEORGE JOSEPH III
摘要:The invention relates to methods of inhibiting SARS-related coronavirus viral replication activity comprising contacting a SARS-related coronavirus protease with a therapeutically effective amount of a SARS 3C like protease inhibitor of formula (I), and compositions comprising the same.

专利号:WO-2022265577-A2
优先权日:2021-06-15
标题:Coronavirus enzyme modulators, methods of synthesis and uses thereof