CAS: 29848-57-5; 1-(Difluoromethyl)-4-Nitrobenzene

上下游产品

4-nitrobenzaldehdye 4-nitrobenzaldehyde hydrazone 4-nitrobenzaldehyde semicarbazone 2-(4-nitrophenyl)-1,3-dithiolane N-[4-(difluoromethyl)phenyl]acetamide α,α-difluoro-4-nitrobenzyl phenyl ether (difluoro(4-nitrophenyl)methyl)(phenyl)sulfide 1-(Azido-difluoro-methyl)-4-nitro-benzene

📜对硝基苯甲醛置于氟化钛(III),4-二氟化碘甲苯,一水合肼体系中,用 乙醇,二氯甲烷 用作溶剂,化学反应 1.0H,反应生成4-二氟甲基硝基苯
参考文献:苯甲醛hy的脱氮二卤代合成芳基二卤甲烷
标题:苯甲醛hy的脱氮二卤代合成芳基二卤甲烷
摘要:我们报告了苯基重氮甲烷的脱氮二卤化反应,其中高价碘试剂phicl 2和tolif 2充当元素氯和氟的替代物.描述了从碘到卤素重氮甲烷的卤素转移,以及碘和之间的串联氧化二卤化反应.这是此反应中首次使用非α稳定的重氮化合物,可有效合成芳基二氟甲烷(archf 2)和芳基二氯甲烷(archcl 2)衍生物.
Doi:10.1002/adsc.201700393

专利信息

专利号:US-2025250234-A1
优先权日:2022-04-12
标 题:Fluoroalcohols as co-solvents for chemical synthesis and methods for producing the same
发明人：COLBY DAVID; ISLAM BAHARUL
权利人:UNIV MISSISSIPPI
摘要:In one aspect, the disclosure relates to a method for the in situ generation of formaldehyde for the hydroxymethylation of difluoroenolates to create 2,2-difluoroethanols having a range of solubilities, acidity, basicity, and other physical properties. The method also allows the production of formaldehyde-d 2 for hydroxy deuteromethylations and constitutes a new synthetic method for 2,2-difluoro-1,1-deuteroethanols. In one aspect, disclosed method is compatible with α,α-difluorobenzyl carbanions generated from the release of trifluoroacetate from electron-deficient aromatic and heteroaromatic rings and can be conducted under mild conditions with high yields. Also disclosed herein are 2,2-difluoroethanols generated by the disclosed method and methods of using the 2,2-difluoroethanols as solvents or co-solvents for organic synthesis, metal catalyzed reactions, asymmetric processes, carbohydrate chemistry, and medicinal chemistry.