CAS: 2382-65-2; Guanosine Cytidine 3',5'-Monophosphate

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Phosphoric acid (2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester (2R,3R,4R,5R)-2-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl estercytidine 2',3'-cyclic monophosphate G cytidine 3'-monophosphate cytidine-2'-monophosphate

📜在 Ammonium Hydroxide,Syn-4-硝基苯甲醛肟,四甲基胍体系中,化学反应生成胞苷酰-(3',5')-鸟苷
参考文献:1' #,2',3',4' #,5',5"-2 H 6-β-D-核糖核苷和1' #,2',2",3',4' #,5的合成',5″-2 H 7-β-D-2'-脱氧核糖核苷用于选择性抑制部分氘化的oligo-Dna,Oligo-Rna和2,5A核中的质子共振(1 H-NMR窗口)
标题:1' #,2',3',4' #,5',5"-2 H 6-β-D-核糖核苷和1' #,2',2",3',4' #,5的合成',5″-2 H 7-β-D-2'-脱氧核糖核苷用于选择性抑制部分氘化的oligo-Dna,Oligo-Rna和2,5A核中的质子共振(1 H-NMR窗口)
摘要:阮内镍-2 H 2 O在甲基α/β-D-呋喃核糖苷[α/β= 〜3:10] 1的差向异构体混合物上的交换反应产生了甲基1 #,2,3,4 #,5,5'-2 H 6-α/β-呋喃核糖苷2 [在c2,C3,C5 / 5'处为97原子%2 H;C 4(c4 #)〜85原子%2 H ;在c1(c1 #)]处约20个原子%2 H,以60-80%的收率获得,同时还得到了差向异构的木糖和阿拉伯糖副产物.在干燥的吡啶中将粗产物2甲苯磺酸化,并在硅胶柱上小心分离,得到纯的1-O-甲基-2,3,5-三-O-(4-甲苯甲酰基)-α/β-D-1#,2,3,4 #,5,5'-2 H 6-核呋喃糖苷4(48%).4转化为1-O-乙酰基-2,3,5-三-O-甲苯甲酰基-α/β-D-1 #,2,3,4 #,5,5'-2 H 6-核呋喃糖苷6( 82%的人提供了合成氘核糖核苷用于rna或dna合成的关键组成部分.然后将化合物6与甲硅烷基尿嘧啶,N
Doi:10.1016/s0040-4020(01)82001-9

专利信息

专利号:US-7541165-B2
优先权日:2001-10-30
标 题 :Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
权利人:RIBOMED BIOTECHNOLOGIES INC
摘要:The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; using a chain terminator to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase. In one aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription.

专利号:US-2004054162-A1
优先权日:2001-10-30
标 题:Molecular detection systems utilizing reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
摘要:The present invention provides methods for detecting the presence of a target molecule by the use of nucleotide analogs containing moieties that enable detection. Such analogs may be incorporated into nucleic acids. In one embodiment, nucleotide analogs are used in a process generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators or chain terminators to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase.

专利号:US-8324181-B2
优先权日:2005-11-17
标题 :Modulation of gene expression by oligomers targeted to chromosomal DNA
发明人：COREY DAVID R; SHAMES DAVID S; JANOWSKI BETHANY A; MINNA JOHN D
权利人:COREY DAVID R; SHAMES DAVID S; JANOWSKI BETHANY A; MINNA JOHN D; UNIV TEXAS
摘要:Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.

专利号:US-2005214796-A1
优先权日:2003-10-29
标题 :Compositions, methods and detection technologies for reiterative oligonucleotide synthesis
发明人：HANNA MICHELLE M
权利人:HANNA MICHELLE M
摘要:The present invention provides methods for detecting the presence of a molecule of interest by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a polynucleotide sequence and detecting said products. The invention also provides for methods of multiplex abortive transcription. In a further aspect, the invention provides for the use of dendrimers containing abortive promoter cassettes. In one aspect, the invention provides for abortive promoter cassettes suitable for use in the present invention. In one aspect the products of abortive transcription are detected with the use of mass spectrometry. In another aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription that are detected, including by mass spectrometry.

专利号:US-2006194311-A1
优先权日:2002-12-06
标题:Lna-cpg conjugates
发明人：CATCHPOLE IAN R
权利人:CATCHPOLE IAN R
摘要:The present invention relates to novel compositions comprising DNA attached to an immunostimulatory oligonucleotide (CpG) via a locked nucleic acid oligonucleotide of a defined sequence. In particular the present invention provides compositions comprising a plasmid containing a gene encoding a protein of interest, wherein said plasmid may be introduced to a tissue or cell and the gene expressed, complexed to the LNA-CpG. Also provided is a method of co-synthesis of CpG and LNA to form compositions for use as adjuvants with DNA plasmid vaccines.

专利号:EP-1622923-A4
优先权日:2003-04-29
标题 :MOLECULAR DETECTION SYSTEMS USING THE REITERATIVE SYNTHESIS OF OLIGONUCLEOTIDES