CAS: 2199-87-3; 6-Bromo-2-Oxo-2H-Chromene-3-Carboxylic Acid

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CAS号2199-90-8 6-溴香豆素-3-甲酸乙酯 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号1761-61-1 5-溴水杨醛 | CAS号90-02-8 水杨醛 | CAS号25016-01-7 5-溴-2-甲氧基苯甲醛 | CAS号89228-64-8 6-bromo-N-hydro... | CAS号82486-43-9 Benzaldehyde,5-... | CAS号76693-35-1 6-溴-3-氰基香豆素 | CAS号141-82-2 丙二酸 | CAS号2199-94-2 6-溴-2-氧代-2H-1-苯...

5-溴水杨醛置于哌啶,Sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应生成6-溴香豆素-3-甲酸
参考文献:香芹酚衍生物作为幽门螺杆菌菌株和 Ags 细胞增殖双重抑制剂的合成和生物学评价
标题:香芹酚衍生物作为幽门螺杆菌菌株和 Ags 细胞增殖双重抑制剂的合成和生物学评价
摘要:本研究报告了一系列基于香芹酚的化合物的合成,结构评估,针对多种幽门螺杆菌菌株的微生物筛选以及针对人胃腺癌细胞(ags)细胞的抗增殖活性.结构分析包括元素分析,1H/13C/19F NMR 谱和晶体学研究.构效关系表明,在醚类衍生物中,特定吸电子基团(cf3和no2)的取代,特别是在苄基环的对位上,可以提高抗菌活性,而苄基环上的给电子基团则可以提高抗菌活性.相对于母体化合物,醚烷基链不耐受 (Mic/mbc = 64/64 µg/ml).酯衍生物(香豆素-香芹酚杂化物)的抑制活性略有增强,Mic 值高达 8-16 µg/ml.还分析了对幽门螺杆菌表现出最低 Mic/mbc 活性的最有趣的化合物(其中,化合物 16 和 39 对所有评估菌株的 Mic/mbc 值范围在 2/2 至 32/32 µg/ml 之间)与 5-氟尿嘧啶相比,它们能够减少 Ags 细胞的生长.一些衍生物可以被视为新的先导
Doi:10.3390/ph13110405

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-113024499-A
优先权日:2021-03-17
标 题 :A kind of green synthesis method of coumarin-3-carboxylic acid compounds