CAS: 18698-96-9; 2-(2-Iodophenyl)Acetic Acid

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CAS号40400-15-5 2-碘苯基乙腈 | CAS号103-82-2 苯乙酸 | CAS号59473-45-9 邻碘氯苄 | CAS号5344-90-1 2-氨基苯甲醇 | CAS号88-67-5 邻碘苯甲酸 | CAS号5159-41-1 2-碘苄醇 | CAS号66370-75-0 2-(2-碘苯基)乙酸甲酯 | CAS号615-37-2 2-碘甲苯 | CAS号40400-13-3 邻碘溴苄 | CAS号103-82-2 苯乙酸 | CAS号1298062-64-2 2-[2-(3,3-dimet... | CAS号1298062-67-5 [2-(2-ox°Cycloh... | CAS号1298062-65-3 {2-[2-(1-adaman... | CAS号1092964-60-7 2-[2-(2-oxobuty... | CAS号39959-51-8 2-碘苄胺 | CAS号5159-41-1 2-碘苄醇 | CAS号26059-40-5 2-(2-碘苯基)-1-乙醇

苯乙酸置于碘苯二乙酸,碘,Palladium Diacetate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,反应生成2-碘苯乙酸
参考文献:镍促进的串联还原还原环化实现的四氢萘并[2,3-B ]呋喃的立体定向合成.
标题:镍促进的串联还原还原环化实现的四氢萘并[2,3-B ]呋喃的立体定向合成.
摘要:首次有效地实现了镍介导的反式四氢萘并[2,3-B ]呋喃立体选择性合成的级联反应.温和的还原体系可以容易地由廉价且空气稳定的材料产生,并显示出以前很难或不可能通过其他方法获得的取代基的宽位置耐受性.还报道了易于合成新的治疗剂(异)脱氧鬼臼毒素的类似物.另外,公开了固有的底物控制用于环化过程中观测到的独特立体选择性.
Doi:10.1021/acs.Orglett.6B02665

专利信息

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4334079-A
优先权日:1980-11-03
标 题:Synthesis of substituted benzyl esters
发明人：GREENE JAMES M; BUNNELL CHARLES A
权利人:LILLY CO ELI
摘要:A process for preparing certain substituted benzyl esters of phenylacetic acids by esterification in a solvent in which the salt of the acid is insoluble, and in the presence of a phase transfer catalyst.

专利号:WO-2023137518-A1
优先权日:2022-01-21
标题 :Platinum complexes
发明人：ALDRICH-WRIGHT JANICE; GORDON CHRISTOPHER; DEO KRISHANT M; KHOURY ALEEN; MCGHIE BRONDWYN; APUTEN ANGELICO; PLATTEN-MENTI MARIA; RASHID FATIN; JURISINEC ASHLEY; SOLIMAN SARAH
权利人:WESTERN SYDNEY UNIV
摘要:The present disclosure relates to platinum complexes, and in particular platinum(II) and platinum(IV) complexes. The present disclosure also relates to synthesis of the platinum complexes, and to intermediates for the synthesis of the platinum complexes. The present disclosure also relates to methods and use of the platinum complexes for treating cancer.

专利号:US-2013261317-A1
优先权日:2010-09-27
标题 :Methods for preparing synthetic bile acids and compositions comprising the same
发明人：MORIARTY ROBERT M; RAO PHOTON
权利人:MORIARTY ROBERT M; RAO PHOTON; KYTHERA BIOPHARMACEUTICALS INC
摘要:This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C 14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation. In preferred embodiments, bile acids are provided herein which have substituents on the B-ring and/or D-ring side chain and optionally on the hydroxy group of the A-ring.

专利号:CN-106518822-B
优先权日:2016-10-31
标题 :Synthesis of strigolactone (±)-GR24 and 4-substituted (±)-GR24