CAS: 172611-72-2; 2-(1-Hydroxy-3-Methylbutylidene)-5,5-Dimethylcyclohexane-1,3-Dione

相似化合物

94142-97-9 122772-35-4 155953-49-4

5,5-Dimethyl-3-Oxocyclohex-1-En-1-Yl 3-Methylbutanoate置于aluminum (III) Chloride体系中,用 二氯甲烷 用作溶剂,化学反应 1.5H,以94%的收率获得5,5-二甲基-2-(3-甲基丁酰基)-1,3-环己二酮
参考文献:Differentially Protected Orthogonal Lanthionine Technology
标题:Differentially Protected Orthogonal Lanthionine Technology
摘要:本发明提供了一种合成至少含有一个分子内桥连接的多肽的方法.本发明还提供了一种合成含有两个分子内桥连接的多肽的方法,其中这两个分子内桥连接形成两个重叠环,两个串联环或两个嵌套环.本发明还提供了一种合成乳酸抗生素,包括nisin A的方法.此外,本发明提供了通过本文所披露的方法合成的分子内桥连接的多肽和差异保护的正交乳酸硫氨酸.

专利信息

专利号:US-7786259-B2
优先权日:2001-05-23
标题:Attachment and elaboration strategies for inverse peptide synthesis
发明人：GUTHEIL WILLIAM G
权利人:UNIV MISSOURI
摘要:The present invention provides a process for preparing an immobilized peptide derivative of formula (Vb): n ncomprising reacting a functionalized solid support comprising Sub-L wherein Sub is a solid support and L is a cleavable linker, with H—[NH—A—C(O)]—O(tBu), then reacting the immobilized product with compound of the formula RHN—A—C(O)OH, wherein the RHN—A—C(O) group is the residue of a N-protected α-amino acid, in the presence of a coupling agent, to yield an immobilized peptide derivative of the formula (Vb).