CAS: 152-93-2; 2,6-Diamino-5-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Pyrimidin-4(1H)-One
该化合物是一种天然的藻类,主要见于Vicia faba的种子中,通常称为fava豆;它被归类为甘蓝,以其结构上与其他化合物(如共产素)相似而著称;维辛的特征是它有可能在某些个人中造成氧化性压力,特别是那些在酶甘蔗-6-磷酸脱氢酶(G6PD)中存在缺陷的人,导致血糖贫血;该化合物的分子配方反映其复杂的结构,包括多种功能组;维辛在水中溶解并表现出一种痛苦的味道;在植物生理学中的角色被认为与防止草药和病原体的防御机制有关;除了生物意义外,还研究过其潜在的致癌性影响,尽管在治疗应用中的安全和功效需要进一步调查;
- 英文名称2,6-Diamino-5-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Pyrimidin-4(1H)-One
- 中文名称蚕豆甙
- IUPAC名称2,6-diamino-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pyrimidin-4(1H)-one
- 其它别名2,6-Diamino-5-(β-D-Glucopyranosyloxy)Pyrimidin-4-Ol; Divicine β-D-Glucopyranoside; Vicine【phytotoxin】; Vicioside; Vicine(Sh); 2,6-Diamino-5-(Beta-D-Glucopyranosyloxy)-4(1H)-Pyrimidinone; Divicine Beta-D-Glucopyranoside
- CAS编号152-93-2
- MFCD编号:MFCD00270447
- EINECS号:205-809-4
- FDA UNII编号:COL14PJW3X
- 分子式:C10H16N4O7分子量:304.26
- 产品CID: 750696
- 产品分类分析化学 → 标准品 → 分析标准品
物理性质
- 熔点242-244 °C
- 沸点627.4±65.0 °C at 760 mmHg
- 闪点333.2±34.3 °C
- 密度2.2±0.1 g/cm3
- PH:D26 -11.7° (c = 3.9 in 0.2N NaOH)
- pKa:9.56±0.50(预测)
- PSA:197.17
- LogP:-2.55
- 折射率1.820
- 蒸汽压0.0±4.2 mmHg at 25°C
- 溶解性Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- 外观形态白色至类白色固体
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物用于人体芳香酶的选择性抑制剂(细胞化P 450 19A1)
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号160812-25-9 ethyl (R)-2-cya...合成工艺路线路线简述
📜Ethyl (R)-2-Cyano-2-[o-(2,3,4,6-Tetra-O-Benzyl-β-D-Glucopyranosyloxy)]Acetate置于palladium On Activated Charcoal 氢气,Sodium Ethanolate体系中,用 乙醇,二氯甲烷,溶剂黄146 用作溶剂,化学反应 73.0H,反应生成蚕豆嘧啶葡糖甙
参考文献:Kunesch,Nicole; Miet,Christine; Poisson,Jacques,Liebigs Annalen Der Chemie,1994,# 11,P. 1059-1064
标题:Kunesch,Nicole; Miet,Christine; Poisson,Jacques,Liebigs Annalen Der Chemie,1994,# 11,P. 1059-1064
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9943544-B2
优先权日:2015-03-18
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer
发明人：BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
摘要:The present invention is a process for bio synthesis of nano arsenic trioxide defined by its low toxicity, higher bio availability and nano particle size with the aid of buttermilk, goat urine, dolichos biflorous and other plant materials such as ginger, momordica charantia and musa paradisiaca . The invention is carried out in different steps involving purification of crude form of arsenic trioxide by boiling it with buttermilk, goat urine and extract of dolichos biflorous in subsequent steps, followed by the trituration of the bio purified arsenic trioxide with extracts of ginger and momordica charantia in subsequent steps and heating of the dry product obtained after trituration with musa paradisiaca resulting in the production of novel nano arsenic trioxide. The product is effective in the treatment of various diseases including different types of cancer in animals and humans. The product obtained through the process is less toxic with higher bio availability.
专利号:US-2016271177-A1
优先权日:2015-03-18
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancer
专利号:EP-2897906-A1
优先权日:2012-09-20
标 题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancers
专利号:EP-2897906-B1
优先权日:2012-09-20
标题 :Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancers
发明人：BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
权利人:BENDALE YOGESH NARAYAN; BENDALE VINEETA YOGESH
专利号:WO-2014045083-A1
优先权日:2012-09-20
标题:Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancers
专利号:KR-20150056848-A
优先权日:2012-09-20
标 题 :Process for bio synthesis of nano arsenic trioxide and its use in treatment of diseases including cancers
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Arbid MS, Koriem KM, Asaad GF, Megahed HA. Effect of the antibiotic neomycin on the toxicity of the glycoside vicine in rats. J Toxicol. 2013;2013:913128. doi: 10.1155/2013/913128. Epub 2013 Jun 12.
2: Lessire M, Gallo V, Prato M, Akide-Ndunge O, Mandili G, Marget P, Arese P, Duc G. Effects of faba beans with different concentrations of vicine and convicine on egg production, egg quality and red blood cells in laying hens. Animal. 2017 Aug;11(8):1270-1278. doi: 10.1017/S1751731116002688. Epub 2016 Dec 29.
3: Rizzello CG, Losito I, Facchini L, Katina K, Palmisano F, Gobbetti M, Coda R. Degradation of vicine, convicine and their aglycones during fermentation of faba bean flour. Sci Rep. 2016 Aug 31;6:32452. doi: 10.1038/srep32452.
合成参考文献
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 103.
参考文献:10.3897/zookeys.92.1157
摘要:Roland G, Jonas E. Definition and Revision of the Orthrius-group of genera (Coleoptera, Cleridae, Clerinae). Zookeys. 2011 Apr 28;(92):35–60.
📝 需求与反馈
尽可能描述清楚需求与问题信息
