CAS: 152-11-4; 5-((3,4-Dimethoxyphenethyl)(Methyl)Amino)-2-(3,4-Dimethoxyphenyl)-2-Isopropylpentanenitrile Hydrochloride

上下游产品

N-methylhomoveratrylamine 2-(3,4-dimethoxyphenyl)-2-(3-oxopropyl)-2-isopropylacetonitrile methylamine hydr°Chloride2-(3,4-dimethoxyphenyl)ethylmethylamine hydr°Chloride Verapamil

维拉帕米置于盐酸体系中,用 水,乙酸乙酯 用作溶剂,化学反应 1.0H,以95%的收率获得盐酸维拉帕米
参考文献: Process For The Preparation Of Verapamil[fr] Procédé De Préparation De Vérapamil
标题: Process For The Preparation Of Verapamil[fr] Procédé De Préparation De Vérapamil
摘要:本发明涉及一种制备α-[3-[[2-(3,4-二甲氧基苯基)乙基]甲基]氨基丙基]-3,4-二甲氧基-α-(1-甲基乙基)单盐酸盐(维拉帕米盐酸盐,化学式i的化合物)的方法,该方法包括处理维拉帕米(化学式ia的化合物)与烷基卤酸酯和/或磷酸二氢钠,然后用盐酸处理以获得高产率和高纯度的维拉帕米盐酸盐.

专利信息

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:WO-2017024455-A1
优先权日:2015-08-07
标题:Spirocyclic hydroxyindole imidazolinoxazepine compound and synthesis method thereof
发明人：WANG XINGWANG; ZHANG JUNQI
权利人:ZHANGJIAGANG INST IND TECHNOLOGIES SOOCHOW UNIV
摘要:Disclosed are a spirocyclic hydroxyindole imidazolinoxazepine compound and a synthesis method thereof, in particular being using a diazohydroxyindole and a dibenzoxazepine as reactants, and under the catalysis of iron (II) trifluoromethanesulfonate or p-toluenesulfonic acid monohydrate, synthesizing the product in a solvent. The method disclosed in the invention has the advantages of an easily obtainable raw material, mild reaction conditions, simple and convenient post-treatment, a wide range of available substrates, a high yield and a high diastereoselectivity; and the product obtained by the synthesis can be used for synthesizing the intermediates of drugs and pesticides.

专利号:WO-2025014320-A1
优先权日:2023-07-12
标 题 :Catalyst for ammonia synthesis and method for preparing same
发明人：LEE KYUNGHO; YOON HYUNG-CHUL; BEUM HEE-TAE; KIM SUN HYUNG; SHIM JOON-MOK; JU HYUNG KUK; KIM JAE HYUNG; WOO RA YOON
权利人:KOREA INST ENERGY RES
摘要:The present invention relates to a catalyst for ammonia synthesis, comprising Co, Ce, and Ba, and a method for preparing same. The catalyst additionally comprises an oxide of each of Co, Ce, and Ba or at least one of two or more of the oxides, wherein as a result of XRD analysis of the catalyst, an effective characteristic peak of BaCeO3 having a perovskite structure is observed. The method for preparing the catalyst comprises the steps of: (a) adding a basic aqueous solution to an aqueous solution in which a Co precursor and a Ce precursor are dissolved in distilled water, to induce coprecipitation; (b) heat-treating the product obtained in step (a); (c) adding, to the product obtained in step (b), an aqueous solution in which a Ba precursor is dissolved in distilled water, to induce impregnation; and (d) heat-treating the product obtained in step (c). In addition, when ammonia is synthesized by using the catalyst, ammonia can be synthesized at a lower temperature and a lower pressure than existing noble metal-based (Ru) catalysts, thereby significantly reducing energy consumption and carbon dioxide emission.

专利号:US-8017786-B2
优先权日:2006-05-15
标 题:Substituted β-phenyl-α-hydroxy-propanoic acid, synthesis method and use thereof
发明人：ZHENG XIAOHUI; ZHANG QUNZHENG; WANG SHIXIANG; ZHAO XINFENG
权利人:UNIV NORTHWEST
摘要:The present invention relates to a compound of the formula (I), wherein R 1 , R 2 and R 3 are each independently selected from H, OH, F, Cl, Br, methoxy and ethoxy; or alternatively, R 1 and R 2 together form —OCH 2 O—, R 3 is selected from H, OH, methoxy, ethoxy and halogens; R 4 is OH or acyloxy; R 5 is cycloalkoxyl, amino and substituted amino, and when R 5 is selected from amino, at least one of R 1 , R 2 and R 3 is not H. The present invention further relates to a process for synthesizing a compound of the formula (I), and use of the compound of the formula (I) in the manufacture of a medicament for the prevention or treatment of cardiovascular or cerebrovascular diseases.

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-7442386-B2
优先权日:2001-08-16
标题:Synthesis and use of reagents for improved DNA lipofection and/or slow release prodrug and drug therapies
发明人：DIAMOND SCOTT L; GRUNEICH JEFFREY ALAN
权利人:UNIV PENNSYLVANIA
摘要:The invention relates to compositions and methods for a one-step synthetic technique for making cationic steroid or cationic drug molecules for use as delivery vehicles. The invention further relates to methods for using cationic steroid molecules in lipofection or transfection, delivery of drugs, and for treatment of inflammation and other diseases and disorders. The invention also relates to cationic steroid prodrugs and cationic prodrugs and to methods of modifying drugs.