CAS: 139755-91-2; 5-(2-Hydroxy-5-((4-Methylpiperazin-1-yl)Sulfonyl)Phenyl)-1-Methyl-3-Propyl-1H-Pyrazolo[4,3-D]Pyrimidin-7(6H)-One
- 英文名称5-(2-Hydroxy-5-((4-Methylpiperazin-1-yl)Sulfonyl)Phenyl)-1-Methyl-3-Propyl-1H-Pyrazolo[4,3-D]Pyrimidin-7(6H)-One
- 中文名称西地那非杂质C
- IUPAC名称5-(2-Hydroxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
- 其它别名Desethyl Sildenafil; 5-[2-Hydroxy-5-(4-Methylpiperazinylsulphonyl)Phenyl]1-Methyl-3-N-Propyl-1,6-Dihydro-7H-Pyrazolo[4,3-D]Pyramidin-7-One; 5-[2-Hydroxy-5-[[4-(Methyl)-1-Piperazinyl]Sulfonyl]Phenyl]-1,6-Dihydro-1-Methyl-3-Propyl-7H-Pyrazolo[4,3-D]Pyrimidin-7-One; Sildenafil Ep Impurity C; 5-[2-Hydroxy-5-(4-Methylpiperazinylsulfonyl)Phenyl]-1-Methyl-3-N-Propyl-1,6-Dihydro-7H-Pyrazolo[4,3-D]Pyrimidin-7-One; O-Desethyl Sildenafil; Sildenafil Impurity C; Sildenafil Impurity 3(Sildenafil Ep Impurity C)
- CAS编号139755-91-2
- MFCD编号:MFCD24386513
- EINECS号:641-936-5
- FDA UNII编号:2TEH1FB1FX
- 分子式:C20H26N6O4S分子量:446.53
- 产品CID: 616470
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
📜2-Hydroxy-5-(4-Methylpiperazin-1-Ylsulphonyl)Benzoic Acid置于1-羟基苯并三唑,N,N'-二环己基碳二亚胺,Sodium Hydroxide体系中,用 二氯甲烷,二乙二醇 用作溶剂,化学反应生成西地那非杂质c
参考文献:柠檬酸西地那非的合成及与工艺有关的杂质
标题:柠檬酸西地那非的合成及与工艺有关的杂质
摘要:通过5-[2-羟基-5-(4-甲基哌嗪-1-基磺酰基)苯基]-1-甲基-3-正丙基-1,6-二氢-7H-吡唑并-的o-烷基化合成西地那非[4,3-D]嘧啶-7-1 8被证明是困难的,因为同时发生了嘧啶部分的烷基化.选择性的o-烷基化是通过dcc辅助碳酸酯9的脱羧醚化进行的.
Doi:10.2174/157017811799304304
海关参考信息
- 2921211000-乙二胺
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5719283-A
优先权日:1990-06-20
标 题:Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents
发明人：BELL ANDREW SIMON; BROWN DAVID; TERRETT NICHOLAS KENNETH
权利人:PFIZER
摘要:Compounds of the formula ##STR1## wherein R 1 is H, C 1 -C 3 alkyl, C 3 -C 5 cycloalkyl or C 1 -C 3 perfluoroalkyl; n R 2 is H, C 1 -C 6 alkyl optionally substituted by OH, C 1 -C 3 alkoxy or C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl; n R 3 is H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 7 cycloalkyl, C 1 -C 6 perfluoroalkyl or (C 3 -C 6 cycloalkyl)C 1 -C 6 alkyl; n and Y is chloro, bromo, or fluoro. n The above compounds are intermediates useful in the synthesis of certain pyrazolopyrimidinones which inhibit cyclic guanosine 3', 5'-monophosphate phosphodiesterase.
