CAS: 131825-41-7; 3,5-Dimethylisoxazol-4-Ylisocyanate
该化合物是一种活性有机化合物,主要用作合成化学的多功能构件,其同位素功能组能够有效地参与核循环添加反应,使其对尿素,氨基甲酸盐和其他异环衍生物的合成具有价值.3,5-二甲基新氧氮化物碱酯会提供消毒和电子效应,影响目标应用中的再活动性和稳定性.该化合物在制药和农用化学研究中特别有用,用于建造生物活性脚架.由于水分敏感性,该化合物应在惰性条件下处理.其定义明确的再活动特征和结构特征使专门有机合成成为实用的选择.
- 英文名称3,5-Dimethylisoxazol-4-Ylisocyanate
- 中文名称二甲基异唑四异氰酸酯
- IUPAC名称4-isocyanato-3,5-dimethylisoxazole
- 其它别名3,5-Dimethylisoxazol-4-Yl Isocyanate; 3,5-Dimethylisoxazole-4-Isocyanate; Isoxazole, 4-Isocyanato-3,5-Dimethyl- (9Ci); 3,5-Dimethylisoxazole-4-Isocyanate ; 4-Isocyanoto-3,5-Dimethyl-Isoxazole; 3,5-Dimethyl-4-Isocyanatoisoxazole; 3,5-Dimethyl-4-Isocyanatoisoxazole, 3,5-Dimethyl-4-Isocyanato-1,2-Oxazole
- CAS编号131825-41-7
- MFCD编号:MFCD00119910
- EINECS号:641-351-5
- 分子式:C6H6N2O2分子量:138.13
- 产品CID: 485004
- 产品分类化学试剂 → 有机试剂 → 氰酸酯/异氰酸酯
MSDS等安全信息
欧盟法规
C&L通报上下游产品
4-氨基-3,5-二甲基异恶唑 3,5-Dimethylisoxazol-4-Amine 31329-64-3合成工艺路线路线简述
📜4-氨基-3,5-二甲基异恶唑,三光气 以 四氢呋喃 用作溶剂,化学反应 1.0H,反应生成二甲基异唑四异氰酸酯
参考文献:Tideglusib And Its Analogues As Inhibitors Of Staphylococcus Aureus Srta
标题:Tideglusib And Its Analogues As Inhibitors Of Staphylococcus Aureus Srta
摘要:Sortase A (Srta) Anchors Surface Proteins To The Cell Wall Envelope,And It Has Attracted Increasing Interesting As A Potential Antivirulence Target. Several Small-Molecule Inhibitors For Srta Have Been Developed,But Target Validation Remains Largely Underexplored. Herein,We Report A New Class Of Srta Inhibitors That Supports Antivirulence Therapy Through Small-Molecule Targeting Of Srta. Tideglusib (Td),A Drug Candidate For Myotonic Dystrophy,Was Outstanding In High-Throughput Screening. A Concise Synthetic Route Quickly Provided Td Analogues,And The Structure-Activity Relationships For Srta Inhibition Have Been Established From Those Analogues. Several Compounds Largely Retained The In Vitro Potency And Exhibited A Better Solubility Than Td. Additionally,Td Attenuated Virulence-Related Phenotypes In Vitro And Protected Mice Against Lethal S. Aureus Usa300 Bacteremia. Our Study Indicates That Td And Its Analogues Could Be New Candidates As Srta Inhibitors With Potential In The Development Of New Antivirulence Agents.
Doi:10.1021/acs.Jmedchem.0C00803
海关参考信息
- 2912110000-甲醛
2929109000-其他异氰酸酯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9833457-B2
优先权日:2008-01-25
标题:Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
发明人：MJALLI ADNAN M M; GADDAM BAPU; POLISETTI DHARMA RAO; KOSTURA MATTHEW J; GUZEL MUSTAFA
权利人:VTV THERAPEUTICS LLC
摘要:The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to psoriatic arthritis.
专利号:MX-2010007768-A
优先权日:2008-01-25
标题 :TRICICLIC COMPOUNDS AS MODULATORS OF THE SYNTHESIS OF THE ALFA TUMOR NECROSIS FACTOR AND AS INHIBITORS OF PHOSPHODIESTERASE 4.
专利号:WO-2009094528-A1
优先权日:2008-01-25
标 题:TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS
专利号:US-2012172381-A1
优先权日:2008-01-25
标题 :Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors
专利号:US-2018071297-A1
优先权日:2008-01-25
标题 :Tricyclic compounds as modulators of tnf-alpha synthesis and as pde4 inhibitors
专利号:CA-2711576-C
优先权日:2008-01-25
标 题:Tricyclic compounds as inhibitors of tnf-.alpha. synthesis and as pde4 inhibitors
