CAS: 123-39-7; N-Methylformamide

该化合物是一种极地溶剂,在水中呈现出高沸点和低渗透度,使之成为有机合成,制药配方和催化等各种化学反应和工艺的有效媒介,其特性在稳定性和易于处理方面提供了优势.

结构式图片

相似化合物

51779-32-9 6343-54-0 16066-84-5

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欧盟《植物保护产品法规》统一分类与标签REACH注册ECHA物质ECHA物质食品接触材料-禁用CMR物质化妆品禁用物质清单工作场所安全标识要求C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号107-31-3 甲酸甲酯 | CAS号74-89-5 氨基甲烷 | CAS号10352-28-0 N-(2-苯甲酰基-4-氯苯基)甲酰胺 | CAS号74-88-4 碘甲烷 | CAS号18952-41-5 N-甲基硫代甲酰胺 | CAS号201230-82-2 carbon monoxide | CAS号593-51-1 一甲胺盐酸盐 | CAS号64-18-6 甲酸 | CAS号75-50-3 三甲胺 | CAS号50-00-0 甲醛 | CAS号1117-72-2 Formamide,N-but... | CAS号64-18-6 甲酸 | CAS号74-89-5 氨基甲烷 | CAS号74-90-8 氢氰酸 | CAS号108-89-4 4-甲基吡啶 | CAS号107427-71-4 2-Pyridinecarbo... | CAS号5470-34-8 4'-甲氧基甲酰苯胺 | CAS号3717-38-2 N-甲基-1-金刚烷胺 | CAS号937602-15-8 N-甲基-5-(三氟甲基)吡啶-2-胺 | CAS号4597-87-9 2-甲基氨基吡啶

合成工艺路线路线简述

  • 合成目标产物 N-Methylformamide 主要起始原料 2-Propen-1-Ol, 2-Methyl-, 1-Formate And Methylamine
  • (文献来源)合成步骤主要原料 2-Propen-1-Ol, 2-Methyl-, 1-Formate 和 Methylamine
N-Methyl-Thioformamid置于四丁基高碘酸铵体系中,用 二氯甲烷 用作溶剂,化学反应 0.75H,以86%的收率获得n-甲基甲酰胺
参考文献:Facile Desulfurization Of Thioamides And Thioureas With Tetrabutylammonium Periodate Under Mild Conditions
标题:Facile Desulfurization Of Thioamides And Thioureas With Tetrabutylammonium Periodate Under Mild Conditions
摘要:Thioamides And Thioureas Were Reacted With Tetrabutylammonium Periodate At Room Temperature To Afford The Corresponding Amides And Ureas,Respectively,Under Aprotic Conditions.
Doi:10.1007/s00706-005-0289-8

海关参考信息

专利信息


专利号:US-9012625-B2
优先权日:2009-04-07
标 题 :Method for the synthesis of a trisaccharide
发明人:DÉKANY GYULA; Ã?GOSTON KÃ?ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVÃ?CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS
权利人:DÉKANY GYULA; Ã?GOSTON KÃ?ROLY; BAJZA ISTVAN; BOUTET JULIEN; BØJSTRUP MARIE; FANEFJORD METTE; PÉREZ FIGUEROA IGNACIO; HEDEROS MARKUS; HORVATH FERENC; KOVÃ?CS-PÉNZES PIROSKA; KRÖGER LARS; OLSSON JOHAN; RÖHRIG CHRISTOPH; SCHROVEN ANDREAS; VRASIDAS IOANNIS; GLYCOM AS
摘要:The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.

专利号:US-2012215002-A1
优先权日:2009-10-09
标 题:Synthesis of optically active intermediate for the preparation of montelukast
发明人:LEFORT LAURENT
权利人:LEFORT LAURENT
摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-10696622-B2
优先权日:2016-08-29
标题 :Synthesis of N-vinyl carboxylic acid amides
发明人:DUMOLEIJN KIM; MOONEN KRISTOF; Henricot Alexis; Han Cai Xing Simon
权利人:TAMINCO BVBA; EASTMAN CHEM CO
摘要:Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for producing an N-vinyl carboxylic acid amide is described that eliminates interim solids handling steps during formation of the intermediate compounds, thereby increasing efficiency and reducing cost. The processes and system described herein may be used for the synthesis of N-vinylformamide and its intermediates, including 1-hydroxyethylformamide and 1-alkoxyethylformamide, or for the synthesis of N-methyl,N-vinylformamide and its intermediates, including N-methyl,1-hydroxyethylformamide and N-methyl,1alkoxyethylformamide.

专利号:US-8252928-B2
优先权日:2008-09-16
标题:Processes for the synthesis of five and six membered heterocyclic rings
发明人:WANG PETER X; JIANG TAO; BERBERICH DAVID W
权利人:WANG PETER X; JIANG TAO; BERBERICH DAVID W; MALLINCKRODT LLC
摘要:The present invention provides processes for the synthesis of five and six membered rings. In particular, the present invention provides processes for the synthesis of five and six membered rings in alkaloids.

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人:BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.
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主要参考文献

[参考文献]: A Gescher, Et Al. N-Methylformamide: Antitumour Activity And Metabolism In Mice. Br J Cancer. 1982 Jun;45(6):843-50.
[参考文献]: A Nakazawa, Et Al. Amidic And Acetonic Cryoprotectants Improve Cryopreservation Of Volvocine Green Algae. Cryo Letters. 2012 May-Jun;33(3):202-13.
[参考文献]: Dar-Bin Shieh, Et Al. Mitochondrial Dna Alterations In Blood Of The Humans Exposed To N,N-Dimethylformamide. Chem Biol Interact. 2007 Feb 20;165(3):211-9.
[参考文献]: Ewa Kamieńska-Piotrowicz, Et Al. An Effective Method For Studying Intermolecular Interactions In Binary Liquids With Hydrogen Bonds; Ftir Spectra And Ab Initio Calculations In The N-Methylformamide-Methanol System. J Phys Chem B. 2010 May 6;114(17):5810-8.
[参考文献]: J Mráz, Et Al. N-Methylcarbamoyl-Lysine Adduct In Globin: A New Metabolic Product And Potential Biomarker Of N, N-Dimethylformamide In Humans. Toxicol Lett. 2006 Apr 10;162(2-3):211-8.

合成参考文献


摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 320.
摘要:Aitken, R. A.; Boubalouta, Y., Science of Synthesis Knowledge Updates, (2013) 4, 151.
摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2018) 4, 136.
摘要:Klapars, A., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 235.
摘要:Klapars, A., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 217.
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