CAS: 1190307-88-0; (S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-yl)-4-Fluoro-3-Hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(Phenoxy)Phosphoryl)Amino)Propanoate

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CAS号863329-66-2 (2'R)-2'-脱氧-2'-... | CAS号1256490-31-9 N-[(S)-(4-硝基苯氧基... | CAS号1064684-44-1 索罗布维 | CAS号1256490-49-9 (S)-2-[(R)-(4-n... | CAS号1334513-02-8 N-[(S)-(2,3,4,5... | CAS号793-10-2 p-nitrophenyl p... | CAS号770-12-7 二氯化磷酸苯酯 | CAS号39613-92-8 D-丙氨酸异丙酯盐酸盐 | CAS号108-95-2 苯酚

专利信息

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:WO-2024201393-A1
优先权日:2023-03-29
标 题:Methods for the synthesis of nucleoside analogues and nucleosides analogues derived therefrom
发明人：BRITTON ROBERT; Muir Garrett; ANKETELL MATTHEW JAMES; HUXLEY COHAN; BAIKABI SUPING
权利人:UNIV FRASER SIMON
摘要:The present invention relates to methods for the synthesis of nucleoside analogues. More specifically, the present invention relates to methods for the synthesis of C4' substituted nucleoside analogues via the reaction of a soft nucleophile with a halohydrin ketone.

专利号:US-2015376219-A1
优先权日:2014-06-30
标题 :Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods
发明人：ZHONG MINGHONG
权利人:ZHONG MINGHONG
摘要:A process of regiospecific synthesis of N-9 purine nucleoside analogs in either solution or solid phase synthesis is described. The introduction of the sugar moiety or its analogue on to a 6-heteroarylium purine or its mesomeric betaine so that formation of only the N-9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific introduction of the sugar moiety allows the synthesis of purine nucleoside analogs in high yields without formation of the N-7-positional regioisomers, while the 6-heteroaryliums are leaving groups facilitated for nucleophilic displacement. Solid supported 6-heterarylium purine bases can be used for purine based library synthesis and synthesis of nucleotide monophosphates and polyphosphates. Processes for providing novel 6-heteroarylium purines and their corresponding mesomeric betaines for the regiospecific synthesis of N-9 purine nucleoside analogs and nucleotides are described.

专利号:US-2023364078-A1
优先权日:2022-05-12
标题:Method of preparing nanoparticles comprising poorly water soluble drugs for treating hepatitis
发明人：KIM HYUN CHUL; MOON BYOUNG YONG
权利人:EVEX TECH INC
摘要:The present invention provides nanoparticles which contain a poorly water-soluble drug for treating hepatitis, and a method of producing the nanoparticles. More particularly, the present invention provides a method of producing nanoparticles for treating hepatitis, which includes: a first step of preparing a precursor mixture solution for synthesis of nanoparticles which include a drug for treating hepatitis; a second step of extracting the compound under supercritical or subcritical conditions; and a third step of dispersing the same, as well as the nanoparticles including a poorly water-soluble drug for treating hepatitis with improved bioavailability and without organic solvent residue.

专利号:US-10160779-B2
优先权日:2015-06-22
标 题 :Synthesis of phosphoramidates
发明人：SCHÖNE OLGA; WILHELM THORSTEN
权利人:SANDOZ AG
摘要:A process for preparing a compound of formula (I) or a salt thereof, the process comprising providing a compound of formula (III) wherein PG is an inert electron withdrawing hydroxyl protecting group, reacting the compound of formula (III) with a fluorinating agent, obtaining a compound of formula (II) and deprotecting the compound of formula (II).