CAS: 1156-78-1; 3-(2,4-Dihydroxyphenyl)-5,7-Dihydroxy-4H-Chromen-4-One
该化合物是一种生物活性异爪素衍生物,结构上与gennistein有关,在2'的位置上又增加了一个氢氧基组,这种改变增强了其抗氧化剂和潜在药理特性,包括提高了自由激进清扫能力和金属切合活动,在极地溶剂中表现出显著的稳定性和溶性,使其适合于氧化性应激反应研究和养分发育的研究应用.初步研究表明,它可能会影响细胞信号路径,尽管需要进一步研究以阐明其机制.其纯度和定义明确的结构使它成为分析化学和生物化学的宝贵参考标准.
- 英文名称3-(2,4-Dihydroxyphenyl)-5,7-Dihydroxy-4H-Chromen-4-One
- 中文名称2'-羟基金雀异黄素
- IUPAC名称2′-Hydroxygenistein
- 其它别名Hydroxygenistein, 2'-; 5,7,2',4'-Tetrahydroxyisoflavone; 3-[2,4-Dihydroxyphenyl]-5,7-Dihydroxy-4H-1-Benzopyran-4-One; Hydroxygenistein, 2'-(P)(Call); 3-(2,4-Dihydroxyphenyl)-5,7-Dihydroxy-4H-Chromen-4-One; 2',4',5,7-Tetrahydroxyisoflavone; -Hydroxygenistein; 3-(2,4-Dihydroxyphenyl)-5,7-Dihydroxy-1-Benzopyran-4-One
- CAS编号1156-78-1
- MFCD编号:MFCD00075967
- FDA UNII编号:1R3U5726T2
- 分子式:C15H10O6分子量:286.24
- 产品CID: 195598
- 产品分类天然产物 → 黄酮类化合物
物理性质
MSDS等安全信息
上下游产品
5,7,2',4'-tetramethoxyisoflavone 2',4',5,7-tetrakis(benzyloxy)isoflavone 4',6'-bis(benzyloxy)-2'-(methoxymethoxy)acetophenone (E)-1-(2,4-Bis-benzyloxy-6-hydroxy-phenyl)-3-(2,4-bis-benzyloxy-phenyl)-propenone 3-(2,4-dimethoxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one 7-benzoyloxy-2',4',5-trihydroxyisoflavone Lupinalbin A luteone合成工艺路线路线简述
📜1,3-双(甲氧基甲氧基)苯置于盐酸,正丁基锂,Palladium 10% On Activated Carbon,水,碘,Silver(I) Acetate,Sodium Carbonate,氯化铵体系中,用 四氢呋喃,甲醇,乙二醇二甲醚,乙醚,正己烷,氯仿,水 用作溶剂,化学反应 19.0H,反应生成2'-羟基金雀异黄素
参考文献:Total Synthesis Of The Pyranocoumaronochromone Lupinalbin H
标题:Total Synthesis Of The Pyranocoumaronochromone Lupinalbin H
摘要:The Pyranocoumaronochromone Lupinalbin H Was Synthesized In Three Major Steps,Which Involved Preparation Of 2'-Hydroxygenistein By The Suzuki-Miyaura Reaction,Followed By Oxidative Cyclodehydrogenation Into Lupinalbin A. The Final Step Was The Regiospecific Introduction Of The Dimethylpyran Moiety To Ring A Of Lupinalbin A Via An Aldol-Type Condensation With 3-Methyl-2-Butenal And 6 Pi-Electrocyclization. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2011.09.042
海关参考信息
- 2907221000-对苯二酚
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-114891807-A
优先权日:2022-05-30
标 题:Application of CYP450 gene in regulation and control of synthesis of soybean isoflavone
专利号:CN-117837498-A
优先权日:2024-01-25
标题 :Method for improving and regulating synthesis of flavonoids in saussurea involucrata leaves
专利号:CN-114891807-B
优先权日:2022-05-30
标题:Application of CYP450 gene in regulating and controlling soybean isoflavone synthesis
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Total Synthesis Of Apios Isoflavones And Investigation Of Their Tyrosinase Inhibitory Activity作者:Nana Asebi,Ken-Ichi Nihei |发布日期:2019.10
摘要:Key Steps. In Addition, Aglycones 4 And 5 And Related Natural Isoflavone Cajanin (6) Were Synthesized In Short Steps. Evaluation Of The Inhibitory Activity Of These Compounds Toward Tyrosinase Indicated That All The Compounds Were Active. In Particular, The Half-Maximal Inhibitory Concentration Of Compound 1 Toward Tyrosinase Was Measured To Be 729 μm.
合成参考文献
摘要:Yin T, Liu H, Wang B, Tu GZ, Liang H, Zhao YY. [Chemical constituents from Spatholobus sinensis]. Yao Xue Xue Bao. 2008 Jan;43(1):67–70.
参考文献:10.4014/jmb.0903.00114
摘要:Choi JN, Kim D, Choi HK, Yoo KM, Kim J, Lee CH. 2'-hydroxylation of genistein enhanced antioxidant and antiproliferative activities in mcf-7 human breast cancer cells. J Microbiol Biotechnol. 2009 Nov;19(11):1348–54. doi: 10.4014/jmb.0903.00114.
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