CAS: 115546-67-3; Benzhydryl 2α-Chloromethyl-2β-Methyl-6,6-Dihydropenam-3α-Carboxylate

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(R)-2-[2-(benzothiazol-2-yldisulfanyl)-4-oxo-azetidin-1-yl]-3-methyl-butyl-3-enoic acid benzhydryl ester 6-aminopenicillanic acid benzhydryl-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate-4-oxide Benzhydryl 6α-bromopenicillanate-1-oxide2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penicillin-3α-carboxylic acid diphenylmethyl ester benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate benzhydryl 2α-azidomethyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide benzhydryl 2α-(1,2,3-triazol-1-yl)methyl-2β-methyl-6,6-dihydropenam-3α-carboxylate 1,1-dioxide

📜Benzhydryl 2α-Chloromethyl-2β-Methyl-6,6-Dihydropenam-3α-Carboxylate 1β-Oxide置于吡啶,Diphosphorus Pentasulfide体系中,用 二氯甲烷 用作溶剂,化学反应 18.0H,以67.92%的收率获得他唑巴坦杂质
参考文献:Synthesis And Biological Evaluation Of Sodium 2α-(1,2,3-Triazol-1-yl)Methyl-2β-Methyl-6,6-Dihydropenam-3α-Carboxylate-1,1-Dioxide
标题:Synthesis And Biological Evaluation Of Sodium 2α-(1,2,3-Triazol-1-yl)Methyl-2β-Methyl-6,6-Dihydropenam-3α-Carboxylate-1,1-Dioxide
摘要:The Synthesis And Beta-Lactamase Inhibitory Activity Of Sodium 2 Alpha-(1,2,3-Triazol-1-yl)Methyl-2 Beta-Methyl-6,6-Dihydropenam-3 Alpha-Carboxylate-1,1-Dioxide 2 (R = Na) Is Described. Its Activity Was Compared With Tazobactam 1 (R = Na). Compound 2 Showed Excellent Synergism In Combination With Piperacillin (Pipc) And The Results Were Either Comparable Or Superior To Tazobactam.
Doi:10.1016/0223-5234(94)90139-2