其它别名Butylglycerol; 1,2,3-Heptanetriol Isomer H 0.5 M Solution; 1,2,3-Heptanetriol Isomer T 1 M Solution; 1,2,3-Heptanetriol, High Melting Isomer 98+%; 1,2,3-Trihydroxyheptane; Heptane-1,2,3-Triol; 1,2,3-Heptanetriol, High Melting Isomer, , Mixture Of Diastereoisomers; 1,2,3-Heptanetriol, High Melting Isomer, Mixture Of Diastereoisomers
专利号:US-6090934-A 优先权日:1996-10-20 标 题:Universal support for the synthesis of oligonucleotides 发明人:KUMAR PRADEEP; GUPTA KAILASH CHAND 权利人:COUNCIL SCIENT IND RES; DBT GOVERNMENT OF INDIA 摘要:A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer support through a covalent linkage and the other hydroxyl group is protected by an acid labile group.
专利号:US-9303055-B2 优先权日:2001-03-14 标题 :Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports 发明人:GAO XIAOLIAN; ZHANG HUA; YU PEILLIN; LEPROUST ERIC; PELLOIS JEAN PHILIPPE; XIANG QIN; ZHOU XIAOCHUAN 权利人:UNIV MICHIGAN; UNIV HOUSTON 摘要:A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.
专利号:US-5942608-A 优先权日:1996-10-29 标题:Process for preparing a universal support for the synthesis of oligonucleotides
专利号:US-8546519-B2 优先权日:2007-10-09 标题 :Polyketal compounds, synthesis, and applications 发明人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING 权利人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING; SEGETIS INC 摘要:The invention relates to polyketal compounds. The compounds are synthesized by the selective ketalization of oxocarboxylic acids, e.g. keto acids and semialdehydes, and esters thereof with tetrols and higher polyols that products two or more cyclic ketal ester moieties per molecule, wherein the cyclic ketal moieties are situated in a bis-, tris-, or polyketal conformation. The invention further relates to applications of these compounds and subsequent reactions thereof.
专利号:EP-1006121-B1 优先权日:1998-12-02 标 题:A universal polymer support for the synthesis of oligonucleotides 发明人:KUMAR PRADEEP; GUPTA KAILASH CHAND 权利人:COUNCIL SCIENT IND RES
专利号:DE-69814097-T2 优先权日:1998-12-02 标 题 :Universal polymer carrier for the synthesis of oligonucleotides
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合成参考文献
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