CAS: 103404-57-5; 1,2,3-Heptanetriol

该化合物是一个三醇,意即含有三个氢氧基(-OH)功能组,该化合物的特点是七碳链,有助于将其分类为七碳衍生物;该化合物的特性是七碳链,有助于将其分类为七碳衍生物;该化合物的存在使其成为一个极分子,使其在水中的溶性比非酒精碳氢化合物更强.1,2,3-七丙烯三醇一般是无色的,在室温下具有粘性液体,并且由于其氢氟化物组的氢结合能力而具有相对较高的沸点;该化合物在各种应用中被使用,包括作为有机合成和某些化妆品和药品的可能的中间体,该化合物的结构允许多种异构体形式,但1,2,3 位置的氢氧组的具体安排对其化学行为和再活动至关重要.

结构式图片

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CAS号4938-52-7 1-庚烯-3-醇

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-6090934-A
    优先权日:1996-10-20
    标 题:Universal support for the synthesis of oligonucleotides
    发明人:KUMAR PRADEEP; GUPTA KAILASH CHAND
    权利人:COUNCIL SCIENT IND RES; DBT GOVERNMENT OF INDIA
    摘要:A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer support through a covalent linkage and the other hydroxyl group is protected by an acid labile group.

    专利号:US-9303055-B2
    优先权日:2001-03-14
    标题 :Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
    发明人:GAO XIAOLIAN; ZHANG HUA; YU PEILLIN; LEPROUST ERIC; PELLOIS JEAN PHILIPPE; XIANG QIN; ZHOU XIAOCHUAN
    权利人:UNIV MICHIGAN; UNIV HOUSTON
    摘要:A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.

    专利号:US-5942608-A
    优先权日:1996-10-29
    标题:Process for preparing a universal support for the synthesis of oligonucleotides

    专利号:US-8546519-B2
    优先权日:2007-10-09
    标题 :Polyketal compounds, synthesis, and applications
    发明人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING
    权利人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING; SEGETIS INC
    摘要:The invention relates to polyketal compounds. The compounds are synthesized by the selective ketalization of oxocarboxylic acids, e.g. keto acids and semialdehydes, and esters thereof with tetrols and higher polyols that products two or more cyclic ketal ester moieties per molecule, wherein the cyclic ketal moieties are situated in a bis-, tris-, or polyketal conformation. The invention further relates to applications of these compounds and subsequent reactions thereof.

    专利号:EP-1006121-B1
    优先权日:1998-12-02
    标 题:A universal polymer support for the synthesis of oligonucleotides
    发明人:KUMAR PRADEEP; GUPTA KAILASH CHAND
    权利人:COUNCIL SCIENT IND RES

    专利号:DE-69814097-T2
    优先权日:1998-12-02
    标 题 :Universal polymer carrier for the synthesis of oligonucleotides

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    主要参考文献

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    [参考文献]: J P Allen, Et Al. Crystallization Of Reaction Center From Rhodopseudomonas Sphaeroides: Preliminary Characterization. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4795-9.
    [参考文献]: J P Allen, Et Al. Crystallization Of The Reaction Center From Rhodobacter Sphaeroides In A New Tetragonal Form. Proteins. 1994 Nov;20(3):283-6.
    [参考文献]: Karl Balabanian, Et Al. Leukocyte Analysis From Whim Syndrome Patients Reveals A Pivotal Role For Grk3 In Cxcr4 Signaling. J Clin Invest. 2008 Mar;118(3):1074-84.
    [参考文献]: M A Rosenow, Et Al. Amphiphiles Modify The Properties Of Detergent Solutions Used In Crystallization Of Membrane Proteins. Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):925-7.

    合成参考文献


    参考文献:10.1073/pnas.082666399
    摘要:Okada T, Fujiyoshi Y, Silow M, Navarro J, Landau EM, Shichida Y. Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5982–7.
    参考文献:10.1007/s11120-011-9658-9
    摘要:Sekine F, Horiguchi K, Kashino Y, Shimizu Y, Yu LJ, Kobayashi M, Wang ZY. Gene sequencing and characterization of the light-harvesting complex 2 from thermophilic purple sulfur bacterium Thermochromatium tepidum. Photosynth Res. 2012 Mar;111(1-2):9–18. doi: 10.1007/s11120-011-9658-9.
    参考文献:10.1016/j.jmb.2004.07.044
    摘要:Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol. 2004 Sep 10;342(2):571–83. doi: 10.1016/j.jmb.2004.07.044.
    参考文献:10.1007/s00018-005-5350-6
    摘要:Raman P, Cherezov V, Caffrey M. The Membrane Protein Data Bank. Cellular and Molecular Life Sciences. 2005 Nov 28;63(1):36. doi: 10.1007/s00018-005-5350-6.
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