CAS: 871130-18-6; (8Ar)-18-Hydroxy-8,9-Diphenyldiphenanthro[4,3-D:3',4'-F][1,3,2]Dioxaphosphepine 18-Oxide

该化合物是一种该化合物是一种多用途异构异构体,被广泛用于非对称合成. 该化合物在对应选择性变异中起到有效的催化剂或催化作用,特别是在布伦斯特酸催化反应中. 它的僵硬的V型双酚框架加强了立体控制,在曼尼奇型添加,皮克特-施彭格勒循环和磷酸化等反应中能够产生高度的对等选择性. 磷酸盐形式提高了极地溶剂的溶解性和再活性,同时保持了离子的内在体环境. 它的稳定性和处理方便性使得它成为需要精确不对称感应的学术和工业应用的实用选择. 它在温和条件下使用,在复杂的合成路径上提供了可靠的性表现.

结构式图片

物理性质

MSDS等安全信息

上下游产品

rac-2,2'-diphenyl-[3,3'-biphenanthrene]-4,4'-diol phenylacetylene 2-phenyl-4-phenanthrol Acetic acid 4-methoxy-2-phenyl-phenanthren-1-yl ester

合成工艺路线路线简述

  • 147702-16-7 = 871130-18-6
    反应条件:1.1 Reagents: Pyridine Solvents: Pyridine; 25 °C1.2 Reagents: Phosphorus Oxychloride; 10 Min,0 °C; 6 H,25 °C1.3 Reagents: Water; 0 °C; 2 H,25 °C
    标题:Gram-Scale Preparation Of Vapol Hydrogenphosphate: A Structurally Distinct Chiral Bronsted Acid
    作者:Desai,Aman A.; Et Al
    参考文献:Synthesis 日期:2010 卷标:(12) 页码:2106-2109]

    56751-12-3 = 871130-18-6
    反应条件:1.1 Solvents: Ethanol,Water; 3 H,80 °C2.1 Reagents: Triethylamine Solvents: Diethyl Ether; 16 H,Rt3.1 Reagents: 1H-Tetrazole Solvents: 1,2-Dichloroethane; Rt; 3 H,80 °C3.2 Reagents: Sodium Bicarbonate Solvents: Water3.3 Reagents: Tert-Butyl Hydroperoxide Solvents: Dichloromethane,Decane; 0 °C; 30 Min,0 °C -> Rt4.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Dichloromethane; 20 Min,Rt4.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Chiral Synthetic Equivalents Of 2-Cyano-Ethyl Tetraisopropylphosphorodiamidite: Application To The Synthesis And Resolution Of Chiral Phosphoric Acids
    作者:Isaac,Kevin; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(19) 页码:4099-4106]

    = 871130-18-6
    反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Dichloromethane; 20 Min,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Chiral Synthetic Equivalents Of 2-Cyano-Ethyl Tetraisopropylphosphorodiamidite: Application To The Synthesis And Resolution Of Chiral Phosphoric Acids
    作者:Isaac,Kevin; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(19) 页码:4099-4106]

    147702-16-7 = 871130-18-6 [标题:Reaction Conditions
    标题:Bronsted Acid-Catalyzed Imine Amidation
    作者:Rowland,Gerald B.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2005 卷标:127(45) 页码:15696-15697]

    200810-26-0 + 1609243-09-5 = 871130-18-6
    反应条件:1.1 Reagents: 1H-Tetrazole Solvents: 1,2-Dichloroethane; Rt; 3 H,80 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water1.3 Reagents: Tert-Butyl Hydroperoxide Solvents: Dichloromethane,Decane; 0 °C; 30 Min,0 °C -> Rt2.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Dichloromethane; 20 Min,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Chiral Synthetic Equivalents Of 2-Cyano-Ethyl Tetraisopropylphosphorodiamidite: Application To The Synthesis And Resolution Of Chiral Phosphoric Acids
    作者:Isaac,Kevin; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(19) 页码:4099-4106]

    56183-63-2 + 132203-26-0 = 871130-18-6
    反应条件:1.1 Reagents: Triethylamine Solvents: Diethyl Ether; 16 H,Rt2.1 Reagents: 1H-Tetrazole Solvents: 1,2-Dichloroethane; Rt; 3 H,80 °C2.2 Reagents: Sodium Bicarbonate Solvents: Water2.3 Reagents: Tert-Butyl Hydroperoxide Solvents: Dichloromethane,Decane; 0 °C; 30 Min,0 °C -> Rt3.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Dichloromethane; 20 Min,Rt3.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Chiral Synthetic Equivalents Of 2-Cyano-Ethyl Tetraisopropylphosphorodiamidite: Application To The Synthesis And Resolution Of Chiral Phosphoric Acids
    作者:Isaac,Kevin; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(19) 页码:4099-4106

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合成参考文献

参考DOI号:10.1021/ja952018t
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