CAS: 861393-75-1; N-Cyano-N-5-Quinolinylguanidine

英文名称N-Cyano-N-5-Quinolinylguanidine
中文名称N-氰基-N'-5-喹啉胍
其它别名N-Cyano-N'-5-Quinolinylguanidine; (E)-2-Cyano-1-(Quinolin-5-yl)Guanidine; Guanidine, N-Cyano-N'-5-Quinolinyl-
CAS编号861393-75-1
MFCD编号:MFCD11044084
分子式:C11H9N5分子量:211.23
产品CID: 1862112
产品分类化学试剂 → 有机试剂 → 胍盐

相似结构搜索
InChIKey: HUGUQQCEWIKIDM-UHFFFAOYSA-N
InChI=1S/C11H9N5/c12-7-16(11(13)14)10-5-1-4-9-8(10)3-2-6-15-9/h1-6H,(H3,13,14)
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数2.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338-

上下游产品

5-Aminoquinoline sodium dicyanamideN-[1-({(cyanoimino)[(5-quinolinyl)amino]methyl}amino)-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide 2-(4-chlorophenyl)-N-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)acetamide N-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-[4-(methylthio)phenyl]acetamide N-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(4-cyanophenyl)acetamide

合成工艺路线路线简述

611-34-7 + 1934-75-4 = 861393-75-1
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 47 H,60 °C
标题:Synthesis And Initial Preclinical Evaluation Of The P2X7 Receptor Antagonist [11C]A-740003 As A Novel Tracer Of Neuroinflammation
作者:Janssen,Bieneke; Et Al
参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:2014 卷标:57(8) 页码:509-516]

611-34-7 + 1934-75-4 = 861393-75-1
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; Overnight,60 °C; Cooled
标题:Discovery And Biological Evaluation Of Novel Cyanoguanidine P2X7 Antagonists With Analgesic Activity In A Rat Model Of Neuropathic Pain
作者:Perez-Medrano,Arturo; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2009 卷标:52(10) 页码:3366-3376

📜5-氨基喹啉,Sodium Dicyanamide置于盐酸体系中,用水作为反应溶剂,化学反应 47.0H,以76%的收率获得产物n-氰基-N'-5-喹啉胍
参考文献:Synthesis And Initial Preclinical Evaluation Of The P2X7Receptor Antagonist [11C]A-740003 As A Novel Tracer Of Neuroinflammation
标题:Synthesis And Initial Preclinical Evaluation Of The P2X7Receptor Antagonist [11C]A-740003 As A Novel Tracer Of Neuroinflammation
摘要:神经炎症,尤其是小胶质细胞的激活,被认为在神经退行性疾病的发展中起着重要作用.在激活的小胶质细胞中,嘌呤能p2X7受体的表达上调.a-740003是一种高度亲和力和选择性的p2X7受体拮抗剂,是有前景的候选物,用于开发正电子发射断层扫描成像的放射性示踪剂,以检测神经炎症.为此,合成了[11C]A-740003,并在体内对其示踪剂代谢和生物分布进行了评估.在血浆中,显示出中等代谢速率.在健康大鼠脑中,仅观测到[11C]A-740003的微量摄取,因此无法确定脑中的代谢物.这种最小脑摄取是由于健康脑中p2X7受体表达水平低,还是由于其跨血脑屏障的转运受限,尚待阐明.
DOI:10.1002/jlcr.3206