CAS: 79-43-6; Dichloroacetic Acid

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CAS号64-19-7 冰醋酸 | CAS号26921-58-4 (4-methoxypheny... | CAS号535-15-9 二氯乙酸乙酯 | CAS号79-36-7 二氯乙酰氯 | CAS号79-10-7 丙烯酸 | CAS号116-54-1 二氯乙酸甲酯 | CAS号143-33-9 氰化钠 | CAS号75-87-6 三氯乙醛 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号76-03-9 三氯乙酸 | CAS号10490-06-9 2,2-bis(ethylsu... | CAS号10579-62-1 Ethanone,2,2-di... | CAS号306-83-2 2,2-二氯-1,1,1-三氟乙烷 | CAS号38595-65-2 bis-(2,2-dichlo... | CAS号497-25-6 2-恶唑烷酮 | CAS号25436-06-0 Dichloressigsae... | CAS号381-73-7 二氟乙酸 | CAS号14985-83-2 Acetamide,2,2-d... | CAS号123-93-3 2,2'-硫代二乙酸 | CAS号505-73-7 二硫醇二羟基乙酸

二氯乙酸乙酯置于偶氮二异丁腈,三丁基氧化锡体系中,用 苯 作为反应溶剂,化学反应 1.5H,以100%的收率获得产物二氯乙酸
参考文献:用双(三丁基锡)氧化物温和有效地裂解酯:可用于去除青霉酸酯的保护作用
标题:用双(三丁基锡)氧化物温和有效地裂解酯:可用于去除青霉酸酯的保护作用
摘要:(新戊酰氧基)甲基6,6-二卤代,6α-单取代和6α-卤代1,2-二氧化青霉酸酯,N-苯甲酰甘氨酸甲酯和几种选定的酯可通过双(三丁基锡)氧化物(nbu 3 Sn)2有效水解o的产率为43%至100%.
DOI:10.1016/s0040-4039(00)88468-3

专利信息

专利号:US-2025313590-A1
优先权日:2024-03-16
标题:Phosphoramidite morpholino monomers towards synthesis/convergent synthesis of PMO, TMO, their chimera oligos in 5 prime to 3 prime direction
发明人：SINHA SURAJIT; GHOSH ATANU; BANERJEE ARPAN
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:The present invention relates to 5′-morpholino amidite monomers as 5′-CE/5′- t Bu phosphoramidite morpholino monomers (2) and process chemistry for the efficient synthesis of N-Trityl or monomethoxytrityl (MMTr)-protected 5′-morpholino amidite monomers and their use in the synthesis of phosphorodiamidate morpholino oligonucleotides (PMO), thiophosphoramidate morpholino oligonucleotides (TMO) and their chimeras which can be used for antisense technology or in general oligonucleotides related research.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.

专利号:US-7956011-B2
优先权日:2005-05-04
标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST ROYAL
摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.

专利号:US-5736626-A
优先权日:1996-01-29
标题:Solid support reagents for the direct synthesis of 3'-labeled polynucleotides
发明人：MULLAH KHAIRUZZAMAN BASHAR; ANDRUS WILLIAM A
权利人:PERKIN ELMER CORP
摘要:The compounds of the invention are exemplified by the class of diglycolate synthesis supports particularly useful as support reagents for the direct synthesis of 3'-labeled polynucleotides. Generally, the compounds of the invention have the structure ##STR1## where T is an acid-cleavable hydroxyl protecting group, e.g., 4,4'-dimethoxytrityl; L 1 is a linker for connecting a 3'-terminal nitrogen to carbon; L 2 and L 3 are linkers for connecting oxygen and carbon; W is a solid support, e.g., CPG or polystyrene; L 4 is a linker for connecting the solid support to nitrogen; R 1 and R 2 are nitrogen substituents, e.g., hydrogen, lower alkyl, nitrogen protecting group, or label; and R 3 through R 7 are carbon substituents, e.g., hydrogen or lower alkyl. In a first particularly preferred embodiment, the synthesis supports of the invention are exemplified by compounds having the structure ##STR2## where DMT is 4,4'-dimethoxytrityl and W is polystyrene. In a second particularly preferred embodiment, the synthesis supports of the invention are exemplified by compounds having the structure ##STR3## where DMT and W are defined above.

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.