CAS: 64003-53-8; Ls-Tetrasaccharide A

相似化合物

22900-11-4 55717-54-9 50998-13-5

上下游产品

lacto-N-tetraose cytidine 5'-monophosphate-N-acetylneuraminic acid

📜Lacto-N-Tetraose,胞苷-5'-单磷酸-N-乙酰神经氨酸 在 Galβ1,3(4)Glcnac α2,3 Sialyltransferase,Triton-Cf 54,Sodium Cacodylate,Bovine Serum Albumin体系中,反应 48.0H,获得 (5-Acetamido-3,5-Dideoxy-α-D-Glycero-D-Galacto-2-Nonulopyranosylonic Acid)-(2-3)-β-D-Galactopyranosyl-(1-3)-2-Acetamido-2-Deoxy-β-D-Glucopyranosyl-(1-3)-β-D-Galactopyranosyl-(1-4)-α,β-D-Glucopyranose
参考文献:Combined Chemical And Enzymatic Synthesis Of Sialyloligosaccharides And Characterization By 500-Mhz And Proton And Carbon-13 Nmr Spectroscopy
标题:Combined Chemical And Enzymatic Synthesis Of Sialyloligosaccharides And Characterization By 500-Mhz And Proton And Carbon-13 Nmr Spectroscopy
摘要:
Doi:10.1021/Ja00268A056

专利信息

专利号:WO-2024165611-A1
优先权日:2023-02-07
标题:Production of a disaccharide and/or milk oligosaccharide by a cell with reduced synthesis of udp-glcnac
发明人：BEAUPREZ JOERI; DECOENE THOMAS; VERCAUTEREN ANNELIES
权利人:INBIOSE NV
摘要:The present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. The invention provides a cell for production of a disaccharide and/or an oligosaccharide like a milk oligosaccharide wherein synthesis of UDP-N-acetylglucosamine in said cell is rendered less functional. The invention further provides use of said cell in a cultivation or incubation. The invention also describes methods for the production of a disaccharide and/or an oligosaccharide like a milk oligosaccharide using said cell as well as the purification of said disaccharide and/or oligosaccharide like a milk oligosaccharide.

专利号:WO-2024165524-A1
优先权日:2023-02-06
标 题:Production of a saccharide by a cell with reduced synthesis of lactobionic acid
发明人：BEAUPREZ JOERI; DECOENE THOMAS; VERCAUTEREN ANNELIES
权利人:INBIOSE NV
摘要:The present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. The invention provides a cell for production of a saccharide wherein synthesis of lactobionic acid in said cell is rendered less functional or is knocked out. The invention further provides use of said cell in a cultivation or incubation. The invention also describes methods for the production of a saccharide using said cell as well as the purification of said saccharide.

专利号:US-12378589-B2
优先权日:2016-12-27
标 题 :In vivo synthesis of sialylated compounds
发明人：BEAUPREZ JOERI; COUSSEMENT PIETER; VAN HERPE DRIES; PETERS GERT; VERCAUTEREN ANNELIES
权利人:INBIOSE NV
摘要:This disclosure is in the technical field of synthetic biology and metabolic engineering. More particularly, this disclosure is in the technical field of fermentation of metabolically engineered microorganisms. This disclosure describes engineered micro-organisms able to synthesize sialylated compounds via an intracellular biosynthesis route. These micro-organisms can dephosphorylate N-acetylglucosamine-6-phosphate to N-acetyl glucosamine and convert the N-acetylglucosamine to N-acetylmannosamine. These micro-organisms also have the ability to convert N-acetylmannosamine to N-acetyl-neuraminate. Furthermore, this disclosure provides a method for the large scale in vivo synthesis of sialylated compounds, by culturing a microorganism in a culture medium, optionally comprising an exogenous precursor such as, but not limited to lactose, lactoNbiose, N-acetyllactosamine and/or an aglycon, wherein the microorganism intracellularly dephosphorylates N-acetylglucosamine-6-phosphate to N-acetylglucosamine, converts N-acetyl-glucosamine to N-acetylmannosamine and convert the latter further to N-acetyl-neuraminate.

专利号:US-2002132320-A1
优先权日:2001-01-10
标题:Glycoconjugate synthesis using a pathway-engineered organism
发明人：WANG PENG GEORGE; CHEN XI; LIU ZIYE; ZHANG WEI
摘要:This invention relates to methods and compositions for the production of glycoconjugates. In particular, organisms are provided with at least one heterologous gene encoding an enzyme for regenerating a sugar nucleotide along with at least one glycosyltransterase. Such organisms are useful for the large-scale synthesis of glycoconjugates.

专利号:WO-2024165525-A1
优先权日:2023-02-06
标题:Production of a saccharide, lactobionic acid and/or glycosylated forms of lactobionic acid
发明人：BEAUPREZ JOERI; DECOENE THOMAS; VERCAUTEREN ANNELIES
权利人:INBIOSE NV
摘要:The present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. The invention provides a cell for production of a saccharide with enhanced synthesis of lactobionic acid (LBA) and use of said cell in a cultivation or incubation. The invention also describes methods for the production of a saccharide or of a mixture of a saccharide and LBA using said cell as well as the purification of said saccharide or said mixture of said saccharide and LBA. The invention also provides a cell for production of a glycosylated form of LBA and use of said cell in a cultivation or incubation. Furthermore, the invention describes methods for the production of a glycosylated form of LBA using said cell, as well as for the production of a mixture comprising i) a glycosylated form of LBA and a saccharide or ii) a glycosylated form of LBA, a saccharide and LBA. The invention also describes purification of said glycosylated form of LBA or of a mixture comprising i) a glycosylated form of LBA and a saccharide or ii) a glycosylated form of LBA, a saccharide and LBA.

专利号:US-12123041-B2
优先权日:2018-09-21
标 题:Method for the production of amino sugar-containing products
发明人：MAERTENS JO; BAUWENS DAVID; VAN BELLEGEM WOUTER; COUSSEMENT PIETER; DUCHI DRIES; DE MEY MARJAN
权利人:UNIV GENT
摘要:A method or producing amino sugar (containing) products using metabolically engineered microorganisms is disclosed, wherein the conversion of UDP-N-acetylglucosamine to cell envelope precursors and molecules is reduced by altering the activity of enzymes involved in the synthesis of cell envelope precursors and molecules.