CAS: 6301-02-6; 1-Aminohydantoin

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CAS号67-20-9 呋喃妥因 | CAS号138-07-8 [1-(amin°Carbon... | CAS号590-28-3 氰酸钾 | CAS号6945-92-2 肼基乙酸乙酯盐酸盐 | CAS号67-20-9 呋喃妥因 | CAS号1672-88-4 呋喃烯啶 | CAS号777-34-4 2,4-Imidazolidi... | CAS号64420-15-1 N-(2,4-dioxoimi...

📜Nitrofurantoin置于水体系中,化学反应生成 1-氨基海因
参考文献:呋喃妥因及其光水解产物的光催化降解
标题:呋喃妥因及其光水解产物的光催化降解
摘要:研究了基于tio 2的硝基呋喃酮(nft)(一种广泛使用的药物)及其主要分解产物硝基呋喃醛(nfa)和氨基乙内酰脲(ahd)的光催化降解,并将其与好氧系统中的光解进行了比较.紫外可见分光光度法,Ph,Ic和HPLC测量用于跟踪辐照期间以及随后在黑暗中的变化.快速反->syn(或反->->顺)nft的光异构化(产生i-Nft),在uv激发下,两种异构体的光解速度变慢,导致nfa和ahd的形成.事实证明,I-Nft比nft更具反应性;它也在黑暗中水解.虽然光解不能在120分钟内完全转化nft和i-Nft,但它们在相同照射条件下的光催化过程中会在90分钟内消失,伴随着nfa和ahd的降解以及相当稳定的中间体的积累,被鉴定为5-由nfa形成的羟基呋喃-2-甲醛.nfa的直接光解还提供了这种特征中间体,以及通过加成或缩合然后氧化还原转化形成的几种衍生物.它们在光解过程中分解非常缓慢,而在nfa的光催化过程
DOI:10.1016/j.Jphotochem.2019.112093

专利信息

专利号:US-6528646-B2
优先权日:1998-01-30
标题 :Intermediates for the synthesis of debromohymenialdisine and process thereof
发明人：HORNE DAVID A; YAKUSHIJIN KENICHI
权利人:UNIV COLUMBIA
摘要:The synthesis of C 11 N 5 marine sponge alkaloids (±)-hymenin (1), stevensine (2), hymenialdisine (3), and debromohymenialdisine (4) is described. These natural products are the primary family members of the sponge metabolites that contain a fused pyrrolo[2,3-c]lazepin-8-one ring system with either a 2-aminoimidazole (AI) or glycocyamidine appendage. The key steps in the synthesis centered around the generation of novel azafulvenium ions and their regioselective heterodimerization with AI in order to create the tricyclic core. A rarely used protodebromination/oxidation strategy was employed to selectively generate the desired a-bromo substitution pattern seen in hymenialdisine (3). In addition, the AI moiety was shown to be a useful precursor to the glycocyamidine unit found in 3 and 4, which suggests that AI derived natural products may be the biogenic forerunners to glycocyamidine metabolites.

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:US-2001012891-A1
优先权日:1998-01-30
标 题 :Intermediates for the synthesis of debromohymenialdisine and process thereof

专利号:US-6197954-B1
优先权日:1998-01-30
标题:Intermediates for the synthesis of debromohymenialdisine and processes thereof

专利号:EP-0693072-B9
优先权日:1993-04-08
标题 :Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes

专利号:EP-0693072-A4
优先权日:1993-04-08
标 题 :PROCESS FOR THE SYNTHESIS OF 2-AMINOIMIDAZOLES (BI) SUBSTITUTED IN POSITION 4 and / or 5 FROM 2-AMINOIMIDAZOLES AND ALDEHYDES