CAS: 6228-25-7; 1,3-Dioxane-5,5-Dimethanol

上下游产品

Pentaerythritol Dimethoxymethane Formaldehyd-bis(pentaerythrityl)acetal formaldehyd 5,5-bis-benzoyloxymethyl-[1,3]dioxane 3-phenyl-2,4,8,10-tetraoxa-3-bora-spiro[5.5]undecane 5-hydroxymethyl-5-(4-monomethoxytrityloxy)-1,3-dioxane 5-(4-monomethoxytrityloxy)-5-phthalimidomethyl-1,3-dioxane

📜2,2,8,8-Tetrakis(Trifluoracetoxymethyl)-4,6-Dioxanonan-1,9-Diylbis(Trifluoracetat)置于盐酸,Ion Exchanger Lewatit Mp 5 (Oh-Form)体系中,用 甲醇 作为反应溶剂,化学反应 5.0H,反应生成 1,3-二环氧戊-5,5-甲醇
参考文献:Werle,Peter; Nonnenmacher,Gerhard; Kruse,Karsten,Liebigs Annalen Der Chemie,1980,# 6,P. 938-945
标题:Werle,Peter; Nonnenmacher,Gerhard; Kruse,Karsten,Liebigs Annalen Der Chemie,1980,# 6,P. 938-945

专利信息

专利号:WO-9900440-A1
优先权日:1997-06-26
标 题:Synthesis of a dendritic polyalcohol
发明人：IHRE HENRIK; HULT ANDERS
权利人:PERSTORP AB; IHRE HENRIK; HULT ANDERS
摘要:A process for a double stage convergent synthesis of a polymeric polyalcohol substantially and preferably built up from polyester units and composed of a monomeric or polymeric core to which at least one hyperbranched dendritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymeric or monomeric branching chain extender having three reactive functions of which two are hydroxyl groups and one is a carboxyl group. The two hydroxyl groups of the branching chain extender is in a first step ketal protected by reacting said two hydroxyl groups with a ketal. A second step includes protection of the carboxyl group of said branching chain extender. The ketal protected branching chain extender and the carboxyl protected chain extender are then employed for repeated addition in a number of step yielding a predetermined number of branching generations. The thus synthesized dendron is finally added to a core having reactive hydroxyl or epoxide groups and the ketal protected hydroxyl groups are optionally deprotected.

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:US-6211329-B1
优先权日:1997-06-26
标题:Process for preparation of a dendritic polyol
发明人：REHNBERG NICOLA; PETTERSSON BO; ANNBY ULF; MALMBERG MATS
权利人:PERSTORP AB
摘要:A process for synthesis of a polymeric polyalcohol substantially and preferably built up form polyester units and composed of a monomeric or polymeric initiator molecule to which at least one dentritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymericor monomeric branching chain extender having three reactive functions of which two are hydroxyl groups. The two hydroxyl groups of the ranching chain extender is acetal protected by reaction between said two hydroxyl groups and an acetal-forming carbonyl compound, preferably an aldehyde. The acetal protected branching chain extender is then employed for addition to the initiator molecule of a first branching generation followed by an optional deprotection of the hydroxyl groups by decomposition of acetals and for addition in repeated steps of further branching generations. Additions of branching generations individually employ an acetal protected branching chain extender synthesized from the same or a different branching chain extender and/or acetal-forming carbonyl compound and addition of a branching generation is optionally followed by addition of a spacing generation.

专利号:US-4528386-A
优先权日:1979-07-03
标 题 :Synthesis of 2,4,8,10-tetroxaspiro[5.5]undecane
发明人：POSHKUS ALGIRDAS C
权利人:NASA
摘要:Pentaerythritol can be converted to its diformal, 2,4,8,10-tetroxaspiro[5.5]undecane, by heating it to a temperature within the range of about 110° to 150° C. for a period of up to 10 minutes, in the presence of a slight excess of paraformaldehyde and of a catalytic quantity of an acid catalyst such as sulfuric acid. The reaction may be carried out in two steps, by forming first the monoformal, then the diformal. In any case, total reaction time is about 10 minutes and yield of diformal are greater than 90%. n Previous processes require hours or days, and often, tedious operating procedures.