CAS: 6027-21-0; H-D-Homoser-Oh

相似化合物

672-15-1 172525-85-8 35677-88-4

上下游产品

CAS号3493-10-5 (2R)-methionine... | CAS号206194-18-5 3-AMINO-3-(FURA... | CAS号104347-13-9 D-高丝氨酸内酯盐酸盐 | CAS号348-67-4 D-蛋氨酸 | CAS号51744-82-2 2(3H)-Furanone,... | CAS号41088-89-5 (R)-2-氧代四氢呋喃-3-... | CAS号41088-85-1 Cbz-D-高丝氨酸 | CAS号41088-89-5 (R)-2-氧代四氢呋喃-3-...

(R)-(+)-Alpha-氨基-Gamma-丁内酯盐酸盐置于三乙胺体系中,用 水 作为反应溶剂,化学反应 2.0H,以79.5%的收率获得产物d-高丝氨酸
参考文献:Optical Resolution By Preferential Crystallization Of (R5)-.Alpha.-Amino-.Gamma.-Butyrolactone Hydrochloride.
标题:Optical Resolution By Preferential Crystallization Of (R5)-.Alpha.-Amino-.Gamma.-Butyrolactone Hydrochloride.
摘要:(rs)-α-氨基-γ-丁内酯盐酸盐 [(Rs)-Abl.hcl] 根据红外光谱,溶解度和熔点被发现存在为一种混合物.通过优先结晶法对 (Rs)-Abl.hcl 进行光学分离,得到 (R)-和 (S)-Abl.hcl.得到的 (R)-和 (S)-Abl.hcl 在考虑 (Rs)-Abl.hcl 的溶解度后进行了重结晶,以获得光学纯的 (R)-和 (S)-Abl.hcl.
DOI:10.1248/cpb.44.2322

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-5892038-A
优先权日:1997-12-08
标 题 :Hydroxy-amino acid amides
发明人：DOLLE III ROLAND ELLWOOD; PATEL HITESH K
权利人:PHARMACOPEIA INC
摘要:Compounds of Formula I I are disclosed as inhibitors of plasmepsin and cathepsin D. The compounds are therefore useful to treat diseases such as malaria. In preferred compounds of formula I, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. Intermediates in the solid phase synthesis of compounds of formula I, in which the compounds are attached to a solid support, are also disclosed.

专利号:WO-03047743-A2
优先权日:2001-11-16
标题 :Method for the synthesis of uniquely d-peptides and peptide nucleic acids

专利号:EP-1312680-A1
优先权日:2001-11-16
标题 :Process for the synthesis of all-D-peptides and peptide nucleic acids

专利号:US-5872262-A
优先权日:1996-11-05
标 题:Hydroxy-amino acid amides
发明人：DOLLE ROLAND ELLWOOD III; JOHNSON THEODORE O JR; TAO SHIWEI
权利人:PHARMACOPEIA INC
摘要:Compounds of Formula I I are disclosed as inhibitors of plasmepsin and cathepsin D. The compounds are therefore useful to treat diseases such as malaria. In preferred compounds of formula I, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. Intermediates in the solid phase synthesis of compounds of formula I, in which the compounds are attached to a solid support, are also disclosed.