CAS: 57848-46-1; 4-Bromo-2-Fluorobenzaldehyde

相似化合物

188582-62-9 112704-79-7 179232-29-2

上下游产品

CAS号222978-01-0 4-溴-3-氟苄醇 | CAS号1435-52-5 1,4-二溴-2-氟苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号877129-98-1 N-(4-bromo-2-fl... | CAS号202865-64-3 4-溴-2-氟苯甲醛肟 | CAS号1073-06-9 间溴氟苯 | CAS号153556-42-4 4-溴-3-氟苯甲酸 | CAS号452-74-4 3-氟-4-溴甲苯 | CAS号1095539-84-6 6-溴-1,3-二甲基-1H-吲唑 | CAS号105191-64-8 6-溴-1-苯并噻吩-2-羧酸乙酯 | CAS号43192-33-2 4-溴-2-甲氧基苯甲醛 | CAS号202865-64-3 4-溴-2-氟苯甲醛肟 | CAS号360576-01-8 6-溴苯并[b]噻吩-2-羧酸甲酯 | CAS号259750-61-3 1-(4-溴-2-氟苯基)丙-1-酮 | CAS号248270-23-7 2-(2-氟-4-溴苯基)-1... | CAS号898790-15-3 (4-溴-2-氟苯基)(环丙基)甲酮 | CAS号79762-54-2 6-溴吲唑 | CAS号643094-36-4 4-BROMO-2-PIPER...

4-溴-2-氟苄醇置于叔丁基过氧化氢,四丁基溴化铵体系中,用 癸烷,苯 作为反应溶剂,化学反应 24.0H,以87%的收率获得产物4-溴-2-氟苯甲醛
参考文献:四正丁基溴化铵:温和条件下酒精氧化的一种简单而有效的有机催化剂
标题:四正丁基溴化铵:温和条件下酒精氧化的一种简单而有效的有机催化剂
摘要:首次鉴定出一种简单而有效的有机催化体系,该体系以5 Mol%的四正丁基溴化铵(tbab)为催化剂.该有机催化体系可与多种具有各种催化反应性基团的苄基/烯丙基醇相容.此外,它对仲苄醇的选择性优于脂族醇,对4-(1-羟乙基)苄醇的伯苄醇位具有非常好的选择性.因此,与该tbab有机催化体系相关的反应条件的简单,高效,选择性和温和的特征表明其在合成化学中的广泛应用的潜力.
DOI:10.1002/adsc.201400100

专利信息

专利号:US-12258318-B2
优先权日:2019-06-17
标题 :Synthesis method for 1-methyl-1H-indazole-6-carboxylic acid
发明人：YANG JUN; Xue Duoqing; WU YONG; CHEN LIHUANG; ZHAI LIANHUA
权利人:ACCELA CHEMBIO CO LTD
摘要:The present application provides a synthesis method for 1-methyl-1H-indazole-6-carboxylic acid. The synthesis method comprises: using 2-fluoro-4-bromobenzaldehyde and methylhydrazine as raw materials to obtain 6-bromo-1-methylindazole by means of an annulation reaction, and then performing a methyl formate reaction and a hydrolysis reaction, so as to obtain the 1-methyl-1H-indazole-6-carboxylic acid. The synthesis method provided in the present application can directly synthesize a 1-position methyl substituted indazole without isomers, thereby avoiding the problem that impurities are difficult to be removed in subsequent separation, thus improving the purity of a product. The yield of the annulation reaction can reach 85%.

专利号:US-2010286211-A1
优先权日:2004-10-08
标题:Oxazolidinone derivatives as antimicrobials
发明人：DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
权利人:DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

专利号:US-8692026-B2
优先权日:2010-07-15
标题:Processes for producing 4-bromo-2-methoxybenzaldehyde
发明人：GIARD THIERRY J; MUTTERER VINCENT L; DURVAUX CHRISTOPHE
权利人:GIARD THIERRY J; MUTTERER VINCENT L; DURVAUX CHRISTOPHE; ALBEMARLE CORP
摘要:A new synthesis of 4-bromo-2-methoxybenzaldehyde is reported from 1,4 dibromo 2-fluorobenzene. First, 2-fluoro-4-bromobenzaldehyde is prepared through metal halogen exchange and formylation with a formyl source at 0° C. After crystallization, this intermediate is reacted with methanol in the presence of potassium carbonate. Subsequently, 4-bromo-2-methoxy-benzaldehyde is crystallized.

专利号:US-10077255-B2
优先权日:2010-04-06
标题:Synthesis of chiral 2-(1H-indazol-6-yl)-spiro[cyclopropane-1,3′-indolin]-2′-ones

专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

专利号:US-9051289-B2
优先权日:2013-09-26
标 题 :Process and intermediates for preparing GPR40 agonists
发明人：DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN
权利人:DAHMANN GEORG; WAGNER HOLGER; ECKHARDT MATTHIAS; FRANK MARKUS; SANTAGOSTINO MARCO; SCHNAUBELT JUERGEN; STERTZ UWE; PACHUR THORSTEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of formula I n nwherein R S denotes F or CF 3 , R a denotes H or C 1-4 -alkyl and Z denotes a leaving group or an optionally substituted or protected hydroxyl group, suitable as intermediates in the synthesis of indanyloxydihydrobenzofuranylacetic acids, which are GPR40 agonists, to a process for preparing these intermediates and to the process for preparing the GPR40 agonists making use of an asymmetric catalytic hydrogenation reaction in the presence of a transition metal catalyst and a chiral auxiliary.