CAS: 55610-01-0; 7-Methyl-5H-[1,3]Dioxolo[4',5':4,5]Benzo[1,2,3-De]Benzo[g]Quinoline-5,6(7H)-Dione
该化合物是一种生物活性藻类化合物,产自Stephania cepharantha(一种传统用于草药的植物),具有显著的药理特性,包括抗炎,抗氧化剂和抗菌素活动.从结构上来说,它属于二苯基甲酸酯类,以其角质框架为特征.研究表明,在调制细胞路径中,特别是抑制NF-B信号(它与炎热和诱导过程有关)的潜在应用.它的稳定性和选择性生物活动使它成为药物开发进一步调查的候选物.HPLC和LC-MS等分析方法通常用于隔离和定性,确保研究的高纯度.
- 英文名称7-Methyl-5H-[1,3]Dioxolo[4',5':4,5]Benzo[1,2,3-De]Benzo[g]Quinoline-5,6(7H)-Dione
- 中文名称7-甲基-5H-苯并[G]-1,3-二茂苯并[6,5,4-DE]喹啉-5,6(7H)-二酮
- IUPAC名称7-methyl-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]benzo[g]quinoline-5,6(7H)-dione
- 其它别名5H-Benzo[g]-1,3-Benzodioxolo[6,5,4-De]Quinoline-5,6(7H)-Dione, 7-Methy L-; 7-Methyl-5H-Benzo[g]-1,3-Benzodioxolo[6,5,4-De]Quinoline-5,6(7H)-Dione; Cepharadione A
- CAS编号55610-01-0
- MFCD编号:MFCD26406103
- FDA UNII编号:E5UG6W56QW
- 分子式:C18H11NO4分子量:305.29
- 产品CID: 2491100
- 产品分类天然产物 → 生物碱
物理性质
MSDS等安全信息
上下游产品
oxalyl dichloride合成工艺路线路线简述
📜2-(2-(Benzo[1,3]Dioxol-4-yl)-Phenyl)-N-Methylacetamide,草酰氯置于四氯化锡体系中,用 二氯甲烷 作为反应溶剂,化学反应 72.0H,以33%的收率获得产物头花千金藤二酮a
参考文献:Synthesis And Biological Evaluation Of Cepharadiones A And B And Related Dioxoaporphines
标题:Synthesis And Biological Evaluation Of Cepharadiones A And B And Related Dioxoaporphines
摘要:Described Herein Is The First Total Synthesis And Structural Confirmation Of Cepharadione A,A Naturally occurring Dna Damaging Agent. Also Reported Is The Synthesis Of Cepharadione B,A Closely Related Natural Product,As Well As The Biological Evaluation Of Both Natural Products. Finally,The Preparation And Biological Evaluation Of Novel Dioxoaporphine Analogues Is Described. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2007.06.035
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合成参考文献
参考文献:10.1002/jccs.199800016
摘要:Chiang C, Leu Y, Chan Y, Wu T. Sodium Aristolochates from the Flowers and Fruits of Aristolochia zollingeriana. J Chinese Chemical Soc. 1998 Feb;45(1):93–7. doi: 10.1002/jccs.199800016.
参考文献:10.1016/0031-9422(88)80226-7
摘要:Desai SJ, Prabhu BR, Mulchandani NB. Aristolactams and 4,5-dioxoaporphines from Piper longum. Phytochemistry. 1988 Jan;27(5):1511–5. doi: 10.1016/0031-9422(88)80226-7.
参考文献:10.1248/cpb.47.571
摘要:WU T, LEU Y, CHAN Y. Constituents of the Fresh Leaves of Aristolochia cucurbitifolia. Chem. Pharm. Bull. 1999;47(4):571–3. doi: 10.1248/cpb.47.571.
参考文献:10.1016/s0031-9422(98)00208-8
摘要:Parmar VS, Jain SC, Gupta S, Talwar S, Rajwanshi VK, Kumar R, Azim A, Malhotra S, Kumar N, Jain R, Sharma NK, Tyagi OD, Lawrie SJ, Errington W, Howarth OW, Olsen CE, Wengel SKS. Polyphenols and alkaloids from piper species. Phytochemistry. 1998 Oct;49(4):1069–78. doi: 10.1016/s0031-9422(98)00208-8.
参考文献:10.1248/cpb.47.887
摘要:CHAN Y, LEU Y, WU T. The Constituents of the Leaves of Aristolochia heterophylla HEMSL. Chem. Pharm. Bull. 1999;47(6):887–9. doi: 10.1248/cpb.47.887.
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