CAS: 5416-55-7; (2-Hydroxycyclohexane-1,1,3,3-Tetrayl)Tetramethanol

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CAS号50-00-0 甲醛 | CAS号108-94-1 环己酮 | CAS号6948-40-9 1,5-bis(hydroxy...

📜环己醇置于aluminium Trinitrate,Zinc(II) Nitrate,Sodium Dichromate,硫酸,Calcium(II) Nitrate,Sodium Carbonate,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 3.0H,反应生成 2,2,6,6-四羟甲基环己醇
参考文献:一种尼可莫尔的合成方法
标题:一种尼可莫尔的合成方法
摘要:本发明公开了一种尼可莫尔的合成方法,通过将环己醇和浓硫酸混合制得混合液,将混合液与重铬酸钾溶液进行混合反应,使得环己醇上的醇羟基脱氢进而形成酮,将中间体1和多聚甲醛先进行羟醛缩合反应后,在催化剂的作用下进行康农扎罗反应,进而制得中间体2,在制备中间体2的过程中制备的一种催化剂,该催化剂使得中间体2的产率大大提升,烟酸与二氯亚砜进行反应制得烟酰氯盐酸盐,将烟酰氯盐酸盐与中间体2进一步反应制得尼可莫尔,与传统合成方法中使用吡啶作作为反应溶剂相比,四氢呋喃在使用时不会散发恶臭,且吡啶为毒性较大的物质,操作者在进行操作时,易吸入吡啶进而造成人员伤害,传统的尼可莫尔的产率较低,不适合大规模生产.

专利信息

专利号:US-2023047214-A1
优先权日:2020-02-03
标题:Methods for microwave synthesis of degradable polymers for drug delivery
发明人：MURATOGLU ORHUN K; ORAL EBRU; GRINDY SCOTT
权利人:MASSACHUSETTS GEN HOSPITAL
摘要:Provided herein are methods of making degradable, additive-blended polymeric materials using microwave radiation and catalysts. The methods can include incorporation of therapeutic materials into the polymeric materials. There also are provided polymeric materials made by the methods and medical devices comprising the polymeric materials made by the methods.

专利号:US-6018074-A
优先权日:1995-11-10
标题 :Process for the preparation of polyalcohols
发明人：KRATZ DETLEF; STAMMER ACHIM; WITZEL TOM; BRUDERMUELLER MARTIN
权利人:BASF AKTIENGESELLSHCAFT
摘要:PCT No. PCT/EP96/04922 Sec. 371 Date Oct. 5, 1998 Sec. 102(e) Date Oct. 5, 1998 PCT Filed Nov. 11, 1996 PCT Pub. No. WO97/17313 PCT Pub. Date May 15, 1997A process for the preparation of polyalcohols comprises the stages: (a) Reaction of an alkanal or ketone with formaldehyde in aqueous solution in the presence of a tertiary amine, to form a formates containing polyalcohol product mixture, (b) removal of water, excess tertiary amine, excess formaldehyde (c) heating of remaining mixture from (b) with removal of further formaldehyde and tertiary amine with formation of the formates of the polyalcohol, (d) transfer of tertiary amine removed from stage (b) and/or from stage (c), to synthesis stage (a) and/or to the subsequent transesterification stage (e), (e) transesterification of the resulting formates of the polyalcohol from stage (c) with an alcohol of the formula ROH in the presence of a transesterification catalyst to give polyalcohols and formates of the formula where R is a hydrocarbon radical, preferably alkyl of 1-6, particularly preferably 1-2, carbon atoms, and (f) isolation of the polyalcohols.

专利号:EP-2277934-A1
优先权日:2009-07-24
标 题:Use of highly functional, highly branched or hyperbranched polycarbonates
发明人：HABERECHT MONIKA; BRUCHMANN BERND; MIJOLOVIC DARIJO; STEINBRECHER ANGELIKA MARIA; ELIZALDE OIHANA
权利人:BASF SE
摘要:The present invention relates to the use of specifically designed high-functionality, highly branched or hyperbranched polyesters which contain β, β, β ', β'-tetra (hydroxymethyl) cycloalkanol incorporated as a synthesis component.

专利号:US-2006223945-A1
优先权日:2003-01-21
标 题:Low color polyisobutylene succinic anhydride-derived emulsifiers
发明人：HOLLINGSHURST CLAIRE L; PRICE DAVID; STECKEL THOMAS F; FILIPPINI BRIAN B; HUANG NAI Z
权利人:HOLLINGSHURST CLAIRE L; PRICE DAVID; STECKEL THOMAS F; FILIPPINI BRIAN B; HUANG NAI Z
摘要:The invention relates to new synthesis techniques to form emulsifiers of low color from maleic anhydride and polymers of isobutylene. These emulsifiers satisfy a need for a low color component with a long oil compatible hydrophobic tail and a short hydrophilic moiety.