CAS: 537-47-3; 4-Phenylsemicarbazide

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苯基脲置于sodium Hydroxide,硫酸肼体系中,用 乙醇 作为反应溶剂,化学反应 24.0H,反应生成 4-苯基氨基脲
参考文献:薄荷酮氨基脲和硫代氨基脲作为抗惊厥药.
标题:薄荷酮氨基脲和硫代氨基脲作为抗惊厥药.
摘要:使用适当的合成路线合成了一系列新颖的(+/-)3-薄荷酮半脲(1-7)和硫代氨基脲,并通过薄层色谱和光谱分析对其进行了表征.腹膜内给药后,在三种癫痫模型中建立了合成化合物的抗惊厥活性,这三种模型包括最大的电击惊厥(mes),皮下戊烯四唑(scptz)诱发的惊厥和最小的神经毒性试验.七种化合物均在两种模型中均表现出保护作用,并且n(1)-(4-氟苯基)-N(4)-(薄荷3-一)氨基脲(4)成为最具活性的化合物,其mes Ed(50)为44.15Mg /kg,0.25H时scptz Ed(50)为38.68Mg / Kg.发现这些化合物可提高中脑区域的γ-氨基丁酸(gaba)水平,
DOI:10.2174/157340610791208727

专利信息

专利号:US-3985835-A
优先权日:1973-07-30
标题 :Halogenated esters of phosphorus-containing acids
发明人：D ALELIO GAETANO F
权利人:ALELIO GAETANO F D
摘要:This invention deals with new phosphorus-containing esters having the formula R'''2NP(O) (ORCX=CXR')2 wherein X represents Cl or Br; R represents a divalent hydrocarbon radical of 1-20 carbon atoms; R' represents H, X or R''; R'' represents a monovalent hydrocarbon radical of 1-20 carbon atoms; R''' represents hydrogen, a monovalent hydrocarbon radical of 1-20 carbon atoms, a divalent saturated aliphatic hydrocarbon group having 5 carbon atoms between valencies and forming a cyclic structure with the N, or a derivative of said monovalent hydrocarbon radical in which the derivative group is hydroxy, NH2, NHR'', NR''2, -NR''''K, R''''NHNHC(O)-, R''''NHC(O)NH-, -(N-R-)n-NR'''' , ¦¦ KK R''COO-, R''CONH- or R''O, R'''' represents hydrogen or R''; n represents an integer having a value of 0-50; and K represents hydrogen, R'' or -P(O) (ORCX=CXR')2. These new esters are useful particularly as fire retardants, agricultural chemicals, fuel additives, plasticizers, monomers and intermediates for the synthesis of other useful derivatives.

专利号:US-4719053-A
优先权日:1980-08-01
标题 :Beta-chloroethylsulfonylmethyl-benzoic halides as intermediates
发明人：SCHLAEFER LUDWIG; HAEHNLE REINHARD
权利人:HOECHST AG
摘要:New beta -chloroethylsuflonylmethyl-benzoic acid halides which can serve as fibre-reactive anchors for thesynthesis of novel organic, water-soluble compounds, preferably dyestuffs, having fibre-reactive and fibre-finishing properties, such as preferably dyestuff properties, and containing, as a fibre-reactive group, one or two beta -chloroethylsufonylmethylbenzoic acid amide groups. For the synthesis of these novel fibre-finishing compounds, said new beta -chloroethylsulfonylmethyl-benzoic acid halide compounds are reacted with an organic, water-soluble compound having fibre-finishing properties and continuing one or two amino groups. Also precursors of the fibre-finishing, fibre-reactive compounds, containing said beta -chloroethylsulfonylmethyl-benzxoic acid amid grouping, can be employed for their synthesis. The novel fibre-finishing compounds can be applied onto suitable fibre materials, such as especially cellulose fibre material and natural or synthetic polyamide fibre materials, and fixed on these fibre materials in a manner similar to application and fixation methods usual in the technique for fibre-reactive compounds. The fibre-finished material, such as dyed material, shows very good wet fastnesses.

专利号:US-6291504-B1
优先权日:1999-10-20
标题:Acylsemicarbazides and their uses
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY W
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a new lass of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-3886237-A
优先权日:1971-09-10
标题 :Halogenated phosphonates
发明人：D ALELIO GAETANO F
权利人:ALELIO GAETANO F D
摘要:This invention deals with new phosphorus-containing esters having the formula AND DERIVATIVES THEREOF OBTAINED BY REACTION WITH AN AMINE COMPOUND HAVING AT LEAST ONE HYDROGEN ATTACHED TO THE NITROGEN OF THE AMINE, WHEREIN R represents a divalent hydrocarbon radical containing 1-20 carbon atoms; R'' represents X, hydrogen or R''''; R'''' represents a monovalent hydrocarbon radical containing 1-20 carbon atoms; and X represents chlorine or bromine. These new esters are useful particularly as fire retardants, agricultural chemicals, fuel additives, plasticizers, monomers and intermediates for the synthesis of other useful derivatives.

专利号:WO-0234721-A1
优先权日:2000-10-20
标 题:Acylsemicarbazides and their use as cyclin dependent kinase (cdk) inhibitors
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP; YUE EDDY W
权利人:DU PONT PHARM CO
摘要:The present invention realtes to the synthesis fo a new class of indeno [1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. The invention also provides a novel method of treating cancer or otehr profiferative disease by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative disease by administering a therapeutically effective combination of one of the compounds of teh present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.