CAS: 51336-94-8; 2-Chloro-1-(2,4-Difluorophenyl)Ethanone

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CAS号372-18-9 1,3-二氟苯 | CAS号79-04-9 氯乙酰氯 | CAS号78-95-5 氯丙酮 | CAS号145240-42-2 2,4-二氟-2-羟基苯乙酮 | CAS号141113-41-9 (R)-2-(2,4-二氟苯基... | CAS号171228-49-2 泊沙康唑 | CAS号185302-85-6 2’,4’-二氟苯基苯甲酰基乙酸甲酯 | CAS号86386-73-4 氟康唑 | CAS号782482-50-2 (S)-2-(TERT-BUT... | CAS号86386-76-7 1-[2-(2,4-二氟苯基)... | CAS号86404-63-9 2,4-二氟-α-(1H-1,... | CAS号168479-96-7 1-(2,4-difluoro... | CAS号122263-03-0 2-乙酰氧基-2’,4’-二氟苯乙酮

2',4'-二氟苯乙酮置于n-氯代丁二酰亚胺,对甲苯磺酸体系中,化学反应生成 2-氯-2',4'-二氟苯乙酮
参考文献:级联三硫自由基(s 3 •-)加成/电子脱甲苯磺酸合成1,2,3-噻二唑和异噻唑
标题:级联三硫自由基(s 3 •-)加成/电子脱甲苯磺酸合成1,2,3-噻二唑和异噻唑
摘要:已经开发了三硫自由基阴离子(s 3 •-)与原位形成的偶氮烯烃和α,β-过饱和的n-磺酰亚胺类化合物介导的反应,用于构建1,2,3-噻二唑和异噻唑.s 3 •-是由dmf中的硫化钾原位反应生成的.这两种方法提供了一种新的,安全的和简单的方法来以高收率构建4-取代的1,2,3-噻二唑,5-取代的1,2,3-噻二唑和异噻唑.反应包括在温和条件下通过s 3 •加成形成新的c-s和n-s键和电子脱甲苯基化反应.
DOI:10.1021/acs.Joc.8B01450

专利信息

专利号:US-5349099-A
优先权日:1993-12-13
标题:Process for preparing intermediates for the synthesis of antifungal agents
发明人：KUO SHEN-CHUN; HOU DONALD; ZHAN ZHENG-YUN
权利人:SCHERING CORP
摘要:Disclosed is a process for preparing allylic halides of the formula I ##STR1## wherein X is Cl, Br or I, for use as intermediates in the synthesis of substituted tetrahydrofuran azole anti-fungal agents.

专利号:US-7342003-B2
优先权日:2001-10-25
标 题 :Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs
发明人：MOORMAN ALLAN R; SCANNELL MICHAEL; BALASUBRAMANIAN THIAGARAJAN; OUTCALT RUSSELL; LEUNG EDWARD
权利人:KING PHARMACEUTICALS RES & DEV
摘要:Provided is a method for the synthesis of an aralkyloxyadenosine or an alkoxyadenosine. The method includes protecting the hydroxyl sugar groups with a protecting group to produce a protected halogenated adenosine. The protected halogenated adenosine is alkoxylated, and the hydroxyl sugar groups of the protected halogenated adenosine are deprotected to provide the aralkyloxyadenosine or alkoxyadenosine.

专利号:US-2015376219-A1
优先权日:2014-06-30
标题 :Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods
发明人：ZHONG MINGHONG
权利人:ZHONG MINGHONG
摘要:A process of regiospecific synthesis of N-9 purine nucleoside analogs in either solution or solid phase synthesis is described. The introduction of the sugar moiety or its analogue on to a 6-heteroarylium purine or its mesomeric betaine so that formation of only the N-9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific introduction of the sugar moiety allows the synthesis of purine nucleoside analogs in high yields without formation of the N-7-positional regioisomers, while the 6-heteroaryliums are leaving groups facilitated for nucleophilic displacement. Solid supported 6-heterarylium purine bases can be used for purine based library synthesis and synthesis of nucleotide monophosphates and polyphosphates. Processes for providing novel 6-heteroarylium purines and their corresponding mesomeric betaines for the regiospecific synthesis of N-9 purine nucleoside analogs and nucleotides are described.

专利号:US-6884880-B2
优先权日:2002-08-21
标 题:Process for the preparation of 9-β-anomeric nucleoside analogs
发明人：GUPTA PRANAB K; MUNK STEPHEN A
权利人:ASH STEVENS INC
摘要:A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-β-D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′-β-fluoro and 2′,3′-dideoxy-2′-β-fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.

专利号:US-2006199958-A1
优先权日:2003-04-14
标 题 :Process and intermediates for the preparation of pyrrolidine carboxylic acids
发明人：CVETOVICH RAYMOND; CHUNG JOHN Y; AMATO JOSEPH S; DIMICHELE LISA
权利人:CVETOVICH RAYMOND; CHUNG JOHN Y; AMATO JOSEPH S; DIMICHELE LISA
摘要:A novel process is provided for the preparation of pyrrolidine carboxylic acids, and the useful intermediates obtained therein. These compounds are intermediates for the synthesis of melanocortin-4 receptor (MC-4R), which are useful for the treatment of disorders such as obesity, diabetes, sexual dysfunction, male sexual dysfunction, and female sexual dysfunction.

专利号:US-5132437-A
优先权日:1991-02-12
标题:Synthesis of 1-aminoanthraquinone
发明人：ASLAM MOHAMMAD; AGUILAR DANIEL A
权利人:HOECHST CELANESE CORP
摘要:1-Aminoanthraquinone (1-AAQ) is synthesized by the reaction of 2-chlorobenzyl chloride and xylene in the presence of a solid acid catalyst to yield 2-chloro dimethyldiphenylmethane, subsequent oxidation of the methyl groups, ring closure to form a 1-chloroanthraquinone carboxylic acid, replacement of the 1-chloro group with ammonia, and decarboxylation.