CAS: 4339-72-4; (4As,6As,6Br,8Ar,10S,12Ar,12Br,14Bs)-10-Acetoxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylic Acid
该化合物是来自单叶酸的一种三叶素化合物,这是各种植物中自然产生的一种物质,其特征是白色的,白色的,非白色的晶状的外表,以其潜在的药理特性而著称,包括抗炎,抗氧化剂和肝脏保护效应;奥利诺亚酸乙酸乙酸乙酸酯在乙醇和氯仿等有机溶剂中溶解,但水溶性有限;其分子结构具有单环曲骨骼,有助于其生物活动;该化合物具有医学化学和自然产品研究的兴趣,因为它具有治疗用途,包括在传统医学中的作用;此外,对奥利诺亚酸乙酸乙酸乙酸酯的研究,研究其对代谢病的影响及其调控各种细胞路径的能力;与许多天然化合物一样,有必要进一步研究,以充分阐明其在临床环境中的行动机制和潜在利益.
- 英文名称(4As,6As,6Br,8Ar,10S,12Ar,12Br,14Bs)-10-Acetoxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylic Acid
- 中文名称齐墩果酸 3-乙酸酯
- IUPAC名称(4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-acetoxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
- 其它别名Oleanolic Acid 3-Acetate; (3Beta)- 3-(Acetyloxy)- Olean-12-En-28-Oic Acid; 3β-Acetoxyolean-12-En-28-Oic Acid; 3β-Acetyloxyolean-12-En-28-Oic Acid; Oleanolic Acid Acetate; (4As,6Ar,6As,6Br,8Ar,10S,12Ar,14Bs)-10-Acetoxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylic Acid; (4As,6Ar,6As,6Br,8Ar,10S,12Ar,14Bs)-10-Acetyloxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylic Acid; 3-O-Acetylolealic Acid
- CAS编号4339-72-4
- MFCD编号:MFCD09752429
- 分子式:C32H50O4分子量:498.75
- 产品CID: 1445074
- 产品分类天然产物 → 萜类
物理性质
上下游产品
CAS号508-02-1 齐墩果酸 | CAS号25493-94-1 (4aS,6aR,6bR,10...合成工艺路线路线简述
📜齐墩果酸置于4-二甲氨基吡啶,Potassium Carbonate体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 28.5H,反应生成 齐墩果酸 3-乙酸酯
参考文献:Type And Position Of Linkage Govern The Cytotoxicity Of Oleanolic Acid Rhodamine B Hybrids
标题:Type And Position Of Linkage Govern The Cytotoxicity Of Oleanolic Acid Rhodamine B Hybrids
摘要:
DOI:10.1016/j.Steroids.2021.108876
专利信息
专利号:US-8257754-B2
优先权日:2002-10-21
标 题:Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
专利号:US-8486457-B2
优先权日:2002-10-21
标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
专利号:US-8557306-B2
优先权日:2001-06-20
标 题 :Compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
专利号:US-7431948-B2
优先权日:2001-06-20
标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
发明人：TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
权利人:METAPROTEOMICS LLC
摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Concise Synthesis Of A New Triterpenoid Saponin From The Roots Of Gypsophila Oldhamiana And Its Derivatives As α-Glucosidase Inhibitors作者:Qingchao Liu,Tiantian Guo,Fahui Li,Dong Li
摘要:The First Synthesis Of The Triterpenoid Saponin 1 And Its Derivatives 2-3 Was Efficiently Achieved In An Efficient And Practical Strategy With An Odourless 2-Methyl-5-Tert-Butylphenyl (Mbp) Thioglycoside And A N-Phenyltrifluoroacetimidate Donor As A Key Step, And Their Inhibitory Activities Against α-Glucosidase And α-Amylase Were Evaluated In Vitro. The Preliminary Structure-Activity Relationship
合成参考文献
参考文献:10.1021/np9901579
摘要:Kim N, Desjardins AE, Wu CD, Kinghorn AD. Activity of Triterpenoid Glycosides from the Root Bark of Mussaenda macrophylla against Two Oral Pathogens. J. Nat. Prod. 1999 Sep 08;62(10):1379–84. doi: 10.1021/np9901579.
📝 需求与反馈
尽可能描述清楚需求与问题信息
