专利号:WO-8103020-A1 优先权日:1980-04-22 标 题 :Triazine synthesis 发明人:HARRIS R 权利人:COMMW SCIENT IND RES ORG; HARRIS R 摘要:A process for the synthesis of substituted 1,3,5-triazine compounds of the general formula: (FORMULA) wherein Rs and Rs, which may be the same or different, are selected from the group consisting of hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkylamino, dialkylamino, arylamino, alkyl-arylamino, alkylthio, arylthio, alkoxy and aryloxy (provided that Rs and Rs are not both halogen); and Rs is selected from the group consisting of halogen, alkylamino, dialkylamino, arylamino, alkyl-arylamino and N-heteroaryl; comprises reaction of a substituted halomethyleneiminium salt with a substituted N-cyanoamidine, N-cyanoguanidine, N-cyanocarbamimidate or N-cyanocarbamidothioate. Substituted 1,3,5-triazine compounds having fungal germination inhibition properties are also disclosed. The following compounds 1) 2-chloro-4-phenyl-1,3,5-triazine, 2) 2-chloro-4-phenoxymethyl-6-phenyl-1,3,5-triazine, 3) 2-N-methylphenylamino-4-phenyl-1,3,5-triazin, 4) 2-chloro-4-cyanomethyl-6-phenyl-1,3,5-triazine are also disclosed and claimed.
专利号:WO-2024233848-A1 优先权日:2023-05-10 标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use 发明人:HOUZE JONATHAN B; PANDYA BHAUMIK 权利人:VIGIL NEUROSCIENCE INC 摘要:The present disclosure provides compounds useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
专利号:US-4032322-A 优先权日:1976-06-18 标 题:Isothiazolylformamidine derivatives as herbicides 发明人:GIBBONS LOREN KENNETH 权利人:GIBBONS LOREN KENNETH 摘要:A new class of herbicidal compounds consisting of N'-(substituted-5-isothiazolyl)-N,N-dimethylformamidines in which the 3-substituent on the isothiazole moiety consists of alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino and dialkylamino, and the 4-substituent on the isothiazole moiety consists of cyano, carbamoyl, and nitro, and in which the hydrogen of the dimethylformamidine moiety may be substituted by fluorine, chlorine, bromine, or carbonitrile, exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of members of this class is described in detail, and the utility of representative compounds is exemplified.
专利号:US-4032321-A 优先权日:1976-06-18 标 题 :N,n-dialkyl-n'-(substituted-5-isothioazolyl)-n'-acylureas as herbicides 发明人:GIBBONS LOREN KENNETH 权利人:FMC CORP 摘要:A new class of herbicidal compounds consisting of N,N-dialkyl-N'-(substituted-5-isothiazolyl)-N'-acylureas in which the 3-substitutent on the isothioazole moiety consists of alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, and dialkylamino, and the 4-substituent on the isothiazole moiety consists of cyano, alkoxycarbonyl, and nitro; and in which the nitrogen atom of the N,N-dialkylurea to which the isothiazolyl moiety is bonded, is also bonded to an acyl moiety, exhibits outstanding preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of members of this class is described in detail and the utility of representative compounds is exemplified.