CAS: 33842-02-3; N-(Dichloromethylene)-N-Methylmethanaminium Chloride

该化合物是一种在有机合成中常用的高度活性电子生殖剂,其主要优点在于它能够发挥多种用途的氯甲基化剂的作用,便于在温和条件下将氯甲基组引入各种基体;该化合物与核分裂物具有极好的反作用,使其对合成药品,农用化学品和特殊化学品具有价值;在无水条件下的稳定性确保了受控反应的一贯性;此外,它作为合成七环化合物和其他中间体的前体;建议由于空气中的水分敏感度,在惰性大气中进行适当处理.

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欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

Thiram N,N-Dimethyl-toluol-4-sulfonyl-thioformamid 1-hexene N,N-Dimethylthi°Carbamoyl chloride 1-(Dimethylimonio)-1-(2,6-dimethylphenoxy)methansulfonat [Chloro-(2-chloro-cyclohex-1-enyl)-methylene]-dimethyl-ammonium; chloride (5-benzyl-[1,3,4]oxadiazol-2-yl)-dimethyl-amine

合成工艺路线路线简述

    📜福美双置于氯体系中,化学反应生成 二氯亚甲基二甲基氯化铵
    参考文献:Mironova,D. F.; Vykhrestyuk,N. I.; Kukhar',V. P.,Journal Of Organic Chemistry Ussr (English Translation),1984,Vol. 20,P. 242-245
    标题:Mironova,D. F.; Vykhrestyuk,N. I.; Kukhar',V. P.,Journal Of Organic Chemistry Ussr (English Translation),1984,Vol. 20,P. 242-245

    海关参考信息

    专利信息


    专利号:WO-8103020-A1
    优先权日:1980-04-22
    标 题 :Triazine synthesis
    发明人:HARRIS R
    权利人:COMMW SCIENT IND RES ORG; HARRIS R
    摘要:A process for the synthesis of substituted 1,3,5-triazine compounds of the general formula: (FORMULA) wherein Rs and Rs, which may be the same or different, are selected from the group consisting of hydrogen, halogen, alkoxycarbonyl, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkylamino, dialkylamino, arylamino, alkyl-arylamino, alkylthio, arylthio, alkoxy and aryloxy (provided that Rs and Rs are not both halogen); and Rs is selected from the group consisting of halogen, alkylamino, dialkylamino, arylamino, alkyl-arylamino and N-heteroaryl; comprises reaction of a substituted halomethyleneiminium salt with a substituted N-cyanoamidine, N-cyanoguanidine, N-cyanocarbamimidate or N-cyanocarbamidothioate. Substituted 1,3,5-triazine compounds having fungal germination inhibition properties are also disclosed. The following compounds 1) 2-chloro-4-phenyl-1,3,5-triazine, 2) 2-chloro-4-phenoxymethyl-6-phenyl-1,3,5-triazine, 3) 2-N-methylphenylamino-4-phenyl-1,3,5-triazin, 4) 2-chloro-4-cyanomethyl-6-phenyl-1,3,5-triazine are also disclosed and claimed.

    专利号:WO-2024233848-A1
    优先权日:2023-05-10
    标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
    发明人:HOUZE JONATHAN B; PANDYA BHAUMIK
    权利人:VIGIL NEUROSCIENCE INC
    摘要:The present disclosure provides compounds useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

    专利号:US-4032322-A
    优先权日:1976-06-18
    标 题:Isothiazolylformamidine derivatives as herbicides
    发明人:GIBBONS LOREN KENNETH
    权利人:GIBBONS LOREN KENNETH
    摘要:A new class of herbicidal compounds consisting of N'-(substituted-5-isothiazolyl)-N,N-dimethylformamidines in which the 3-substituent on the isothiazole moiety consists of alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino and dialkylamino, and the 4-substituent on the isothiazole moiety consists of cyano, carbamoyl, and nitro, and in which the hydrogen of the dimethylformamidine moiety may be substituted by fluorine, chlorine, bromine, or carbonitrile, exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of members of this class is described in detail, and the utility of representative compounds is exemplified.

    专利号:US-4032321-A
    优先权日:1976-06-18
    标 题 :N,n-dialkyl-n'-(substituted-5-isothioazolyl)-n'-acylureas as herbicides
    发明人:GIBBONS LOREN KENNETH
    权利人:FMC CORP
    摘要:A new class of herbicidal compounds consisting of N,N-dialkyl-N'-(substituted-5-isothiazolyl)-N'-acylureas in which the 3-substitutent on the isothioazole moiety consists of alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, and dialkylamino, and the 4-substituent on the isothiazole moiety consists of cyano, alkoxycarbonyl, and nitro; and in which the nitrogen atom of the N,N-dialkylurea to which the isothiazolyl moiety is bonded, is also bonded to an acyl moiety, exhibits outstanding preemergence and postemergence herbicidal activity, controlling effectively the growth of a wide spectrum of grassy and broad-leaved plant species. The synthesis of members of this class is described in detail and the utility of representative compounds is exemplified.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Ke-Lai Li, Et Al. Regioselective Syntheses Of 2- And 4-Formylpyrido[2,1-B]Benzoxazoles. J Org Chem. 2009 May 1;74(9):3286-92.

    合成参考文献


    摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 321.
    摘要:Murai, T., Science of Synthesis: Knowledge Updates, (2024) 2, 432.
    摘要:Murai, T., Science of Synthesis: Knowledge Updates, (2024) 2, 439.
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