CAS: 278603-08-0; 3-Benzyl-1-Hexadecyl-2-Methyl-1H-Imidazol-3-Ium Iodide

该化合物是一种四铵化合物,其特点是其结构,其特点是五人环内有正充电的氮原子,该化合物由于存在长期的缺水六十二烷链和一种嗜水性头,因此具有非生物特性,因此适合表面活性剂和乳化剂的应用.苯基组增强了其在有机溶剂中的溶解性,并可能有助于其生物活动.作为一种碘盐,它有可能在极地溶剂中溶解,而长烷链则提供脂性.该化合物还可能具有抗微生物性,从而引起对制药和化妆剂的兴趣.其稳定性和再活性可能受到可参与各种化学反应的碘反作用的影响.

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物理性质

MSDS等安全信息

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合成工艺路线路线简述

    📜溴代十六烷置于potassium Iodide体系中,用 氯仿 用作溶剂,化学反应 36.0H,反应生成1-苄基-3-鲸蜡基-2-甲基咪唑鎓碘化物
    参考文献:Identification And Characterization Of A Potent Antibacterial Agent,Nh125 Against Drug-Resistant Bacteria
    标题:Identification And Characterization Of A Potent Antibacterial Agent,Nh125 Against Drug-Resistant Bacteria
    摘要:合成了新型咪唑化合物,以开发一种新颖有效的抗菌剂(1-苯基-3-鲸烷基-2-甲基咪唑鎓碘化物,Nh125).体外实验表明,Nh125有效抑制了多种不同的组氨酸蛋白激酶.此外,耐氧西林的金黄色葡萄球菌(orsa),耐万古霉素的肠球菌(vre),耐青霉素的肺炎链球菌(prs)以及其他革兰氏阳性和革兰氏阴性细菌对nh125的敏感性很高.
    Doi:10.1271/bbb.64.919

    海关参考信息

    专利信息


    专利号:WO-2024163852-A1
    优先权日:2023-02-03
    标题:Histidine kinase inhibitors as antibacterial agents
    发明人：CARLSON ERIN ELIZABETH; GOSWAMI MANIBARSHA; ESPINASSE ADELINE; JI YINDUO
    权利人:UNIV MINNESOTA
    摘要:The invention provides maleimide derivative compounds of Formula I, as histidine kinase inhibitors, useful for inhibiting bacterial histidine kinases, such as HK853 and AirS, for treating S. aureus bacterial infections, in particular methicillin-resistant S. aureus (MRSA). The invention further provides methods of treating bacterial infection with the. compounds of Formula I, either used alone or in combination with other agents in a therapeutic regimen. Further disclosed is the synthesis of the compounds of Formula I.

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    主要参考文献


    1: Basak A, Abouelhassan Y, Zuo R, Yousaf H, Ding Y, Huigens RW. Antimicrobial peptide-inspired NH125 analogues: bacterial and fungal biofilm-eradicating agents and rapid killers of MRSA persisters. Org Biomol Chem. 2017 Jul 5;15(26):5503-5512. doi: 10.1039/c7ob01028a. doi: 10.1002/cbic.201600622. Epub 2017 Jan 16. doi: 10.4155/fmc.15.189. Epub 2016 Feb 24.
    4: Bender CL, Yang Q, Sun L, Liu SJ. NH125 reduces the level of CPEB3, an RNA binding protein, to promote synaptic GluA2 expression. Neuropharmacology. 2016 Feb;101:531-7. doi: 10.1016/j.neuropharm.2015.03.017. Epub 2015 Apr 2.
    5: McCamphill PK, Farah CA, Anadolu MN, Hoque S, Sossin WS. Bidirectional regulation of eEF2 phosphorylation controls synaptic plasticity by decoding neuronal activity patterns. J Neurosci. 2015 Mar 11;35(10):4403-17. doi: 10.1523/JNEUROSCI.2376-14.2015. doi: 10.1152/ajpheart.00373.2013. Epub 2013 Jun 28.

    合成参考文献


    参考文献:10.1007/978-3-030-29643-8_5
    摘要:Singhal A, Goel S. Impact of Sandstone Quarrying on the Health of Quarry Workers and Local Residents: A Case Study of Keru, Jodhpur, India. 2022. In: Treatment and Disposal of Solid and Hazardous Wastes.
    参考文献:10.1007/s11629-022-7496-1
    摘要:Sati SP, Sharma S, Kothyari GC, Asim M, Sundriyal YP, Malik K, Joshi A, Dobhal H, Rana N, Juyal N. Mountain highway stability threading on the fragile terrain of upper Ganga catchment (Uttarakhand Himalaya), India. J. Mt. Sci. 2022 Dec;19(12):3407–25. doi: 10.1007/s11629-022-7496-1.
    参考文献:10.1007/978-3-031-56858-9_11
    摘要:Mishra A. The Himalayan Ecosystem and Development Paradigm: A Sustainability Perspective. 2024. In: Advances in Asian Human-Environmental Research.
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