CAS: 27512-72-7; Ethychlozate

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CAS号64-17-5 乙醇 | CAS号27328-68-3 5-氯-1H-吲唑-3-乙酸 | CAS号6628-86-0 5-氯-2-硝基苯甲醛 | CAS号63235-32-5 3-氨基-3-(5-氯-2-硝...

📜5-氯-2-硝基苯甲醛置于镍 盐酸,Sodium Hydroxide,甲酸,硫酸,Ammonium Formate,一水合肼体系中,化学反应 4.5H,反应生成吲熟酯
参考文献:口服活性醛糖还原酶抑制剂:吲唑乙酸,氧并哒嗪乙酸和氧并吡啶并哒嗪乙酸衍生物.
标题:口服活性醛糖还原酶抑制剂:吲唑乙酸,氧并哒嗪乙酸和氧并吡啶并哒嗪乙酸衍生物.
摘要:Zopolrestat(1A)及其同类物中的苯并噻唑侧链已被引入到邻苯二甲酰氧乙酸替代品中,包括吲哚,哒嗪酮和带有吡啶侧基的吡啶并哒嗪酮.所得化合物中有效的醛糖还原酶抑制活性与早期的zopolrestat系列产品一样广泛,因此进一步支持了我们的假设,即醛糖还原酶上有一个与苯并噻唑具有强亲和力的结合位点.代表性的新化合物1-[((5,7-二氟-2-苯并噻唑基)-甲基]-1H-吲唑乙酸(62),[6-[[5-(三氟甲基)苯并噻唑-2-基]甲基]-8-氧代-6H-吡啶并[2,3-D]-哒嗪-5-基]乙酸(70),3,4-二氢-4-氧代-5,6-二甲基-3-[(5,7-二氟苯并噻唑(-2-基)甲基]-1-哒嗪乙酸(79)和3,4-二氢-4-氧代-5,6-环己-3--3-[[5-(三氟甲基)苯并噻唑-2-基]-甲基]-1-哒嗪乙酸(82)是有效的醛糖还原酶抑制剂,Ic50分别为30,2.1,5和52
Doi:10.1021/jm00090A002

专利信息

专利号:US-11919928-B2
优先权日:2016-03-16
标题 :Method for producing dihydrotentoxin
发明人：KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:KUMIAI CHEMICAL INDUSTRY CO
摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

专利号:WO-2020226482-A1
优先权日:2019-05-09
标题:Synergistic compositions for controlling plant pathogens with chitinolytic microorganisms / organic acid combinations and method of use thereof
发明人：LAI HONG HENG
权利人:LAI HONG HENG
摘要:The present invention relates to pesticidal compositions and methods for controlling plant pathogens, particularly basal stem rot in the oil palm primarily caused by Ganoderma species. The pesticidal compositions comprising, as active components: (A) Bioactive compound derived from a whole broth culture of an chitinolyic microorganisms, wherein the bioactive compound comprises any or any combination of: chitinolyic microorganism, whole cell broths, liquid cultures, spores, pure cultures, cell fraction, substances, suspensions, supernatants, filtrates, extract or a cell-free extract thereof or metabolite thereof or isolated compounds, wherein the bioactive compound is derived from at least one chitinolyic microorganisms that degrade chitinous substrates. The said chitinolytic microorganism is bacteria belonging to genus Bacillus, Streptomyces and/or fungal genus Trichoderma; (B) at least one organic acid; and (C) at least one pesticide selected from chemical pesticides, microbial pesticides, plant defense activators, cuticle degrading enzymes, cell wall synthesis inhibitors, bacteriocins, antifungal peptides, antimicrobial preservatives, plant oil or plant extract. More specifically, this invention envisions the use of bioactive compounds and/or metabolites from chitinolyic microorganisms in combination essentially of organic acid and the compositions comprising them, in the use form as fungicides and/or insecticides, also be present as 'booster' to other pesticides results in many cases in an expension of pesticidal spectrum of activity or in a prevention of pesticide resistance development. Furthermore, in many cases, synergistic effects are obtained. In various embodiments, the organic acid consists essentially of acetic acid, preferably acetic acid from a fermentation. The formulation is typically applied to agricultural soil or plant material. In a particular, the present invention can be used in combination with a carrier selected from the plant growth nutrient, organic fertilizer or inorganic/organic mixture fertilizer. Although the following description relates almost exclusively to managing basal stem rot (BSR) disease in oil palm primarily caused by Gonoderma species. It will be appreciated by those skill in the art that the invention could be used to treat other diseases and pests of other plants, includes but is not limited to a fungus, bacteria, actinomycete, virus, insects, Acari and/or nematodes.

专利号:CN-105622486-A
优先权日:2015-09-28
标题:A class of bis-indolylmethane compound and its synthesis method and application