CAS: 2353-44-8; 3-Aminopiperidine-2,6-Dione

相似化合物

24666-56-6 25181-50-4 1801140-47-5

上下游产品

CAS号24666-55-5 (2,6-二氧代哌啶-3-基)... | CAS号31140-42-8 3-B°C-氨基-2,6-二氧代哌啶 | CAS号120341-33-5 1-[(tert-butoxy... | CAS号19171-18-7 4-硝基沙利度胺 | CAS号827026-45-9 3-(4-硝基-1-氧代-1,... | CAS号55003-81-1 2-(2,6-二氧代哌啶-3-...

📜Dl-谷氨酰胺置于盐酸,N-羟基丁二酰亚胺,氯化亚砜,碳酸氢钠,N,N'-二异丙基碳二亚胺体系中,用 四氢呋喃,甲醇,甲基叔丁基醚,水 用作溶剂,化学反应 71.33H,反应生成3-氨基-2,6-哌啶二酮
参考文献:一种来那度胺的制备方法
标题:一种来那度胺的制备方法
摘要:本发明提供了一种来那度胺的制备方法.所述来那度胺的制备方法包括制备中间体2‑卤甲基‑3硝基苯甲酸甲酯和中间体3‑氨基哌啶‑2,6‑二酮的步骤,以及利用这两个中间体制备来那度胺的步骤.所述来那度胺的制备方法步骤简单,收率较高,成本较低,有利于工业化生产.

专利信息

专利号:US-10654862-B2
优先权日:2015-03-18
标题 :Methods for the chemical synthesis of pyrrole-linked bivalent compounds, and compositions thereof
发明人：CRAN JOHN
权利人:AVEKSHAN LLC
摘要:The present invention in various aspects relates to the synthesis of pyrrole-linked bivalent compounds, including but not limited to norBNI, as well as pharmaceutical compositions comprising the same.

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:US-2005272934-A1
优先权日:2004-06-01
标题 :Process for the synthesis of thalidomide
发明人：ALPEGIANI MARCO; MAZZONI ANDREA; VERGANI DOMENICO; CABRI WALTER
权利人:ANTIBIOTICOS SPA
摘要:The invention relates to a process for the preparation of thalidomide (I) n n ncomprising the reaction between glutamine (II) n nand a phthaloylating agent, preferably phthalic anhydride, to give N-phthaloyl-glutamine, which is directly transformed in thalidomide.

专利号:US-9303014-B2
优先权日:2013-05-01
标题:Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione
发明人：RUCHELMAN ALEXANDER L; COHEN BENJAMIN M; CHOUDHURY ANUSUYA; KREILEIN MATTHEW M; LEONG WILLIAM W; MAN HON-WAH
权利人:CELGENE CORP
摘要:Provided herein are processes for the preparation of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt thereof.

专利号:UA-45408-C2
优先权日:1997-02-01
标 题 :Substituted piperidine-2,6, -DIONY (Option) METHOD OF PRODUCING (option), pharmaceutical compositions MODELING METHOD immune response of mammals, a method for inhibiting antigen-triggered synthesis of interleukin-2 in mammals

专利号:US-9522899-B2
优先权日:2009-06-01
标 题:Methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2, 6-dioxopiperidine, and intermediates thereof
发明人：YAN RONG; YANG HAO; XU YONGXIANG
权利人:NANJING CAVENDISH BIO-ENGINEERING TECH CO LTD; YAN RONG; NANJIAN CAVENDISH BIO-ENGINEERING TECH CO LTD
摘要:The present invention discloses methods for synthesizing 3-(substituted dihydroisoindolinone-2-yl)-2,6-dioxopiperidine and intermediates thereof, namely, the synthesis of compounds of the Formula (I), with each substitutional group defined in the patent specification. Owing to the advantages of high productivity, little influence to the environment and material accessibility, the methods of the present invention is suitable for industrial production.