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参考文献:occurrence,Synthesis,And Mammalian Cell Cytotoxicity And Genotoxicity Of Haloacetamides: An Emerging Class Of Nitrogenous Drinking Water Disinfection Byproducts
标题:occurrence,Synthesis,And Mammalian Cell Cytotoxicity And Genotoxicity Of Haloacetamides: An Emerging Class Of Nitrogenous Drinking Water Disinfection Byproducts
摘要:The Haloacetamides,A Class Of Emerging Nitrogenous Drinking Water Disinfection Byproduct (Dbps),Were Analyzed For Their Chronic Cytotoxicity And For The Induction Of Genomic Dna Damage In Chinese Hamster Ovary Cells. The Rank Order For Cytotoxicity Of 13 Haloacetamides Was Diacam > Iacam > Bacam > Tbacam > Biacam > Dbcacam > Ciacam > Bdcacam > Dbacam > Bcacam > Cacam > Dcacam > Tcacam. The Rank Order Of Their Genotoxicity Was Tbacam > Diacam Iacam > Bacam > Dbcacam > Biacam > Bdcacam > Ciacam > Bcacam > Dbacam > Cacam > Tcacam. Dcacam Was Not Genotoxic. Cytotoxicity And Genotoxicity Were Primarily Determined By The Leaving Tendency Of The Halogens And Followed The Order I > Br > > Ci. With The Exception Of Brominated Trihaloacetamides,Most Of The Toxicity Rank Order Was Consistent With Structure-Activity Relationship Expectations. For Di-And Trihaloacetamides,The Presence Of At Least One Good Leaving Halogen Group (I Or Br But Not Ci) Appears To Be Critical For Significant Toxic Activity. Log P Was Not A Factor For Monohaloacetamides But May Play A Role In The Genotoxicity Of Trihaloacetamides And Possible Activation Of Dihaloacetamides By Intracellular Gsh And-Sh Compounds. With The Advent Of The U.S. Epa Stage 2 Dbp Regulations,Water Utilities Are Considering The Use Of Disinfectants That Are Alternatives To Chlorine. The Use Of These Alternative Disinfectants Will Shift The Distribution Of Dbp Chemical Classes. The Emergence Of New,Highly Toxic Iodinated,Nitrogenous Dbps,As Illustrated By The Discovery Of Bromoiodoacetamide As A New Dbp,Underscores The Importance Of Comparative Toxicity Studies To Assist In The Overall Goal Of Safer Drinking Water Practice.
Doi:10.1021/es071754H