CAS: 203302-97-0; 3-(Trifluoromethoxy)Phenylacetic Acid

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CAS号251366-51-5 α-bromo-(3-trif... | CAS号29270-33-5 α-溴-4-氟苯乙酸

Triphenyl-[[3-(Trifluoromethoxy)Phenyl]Methyl]Phosphanium;Bromide置于tert-Butylammonium Hexafluorophosphate(V)体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 11.16H,反应生成3-三氟甲氧基苯乙酸
参考文献:通过 C(Sp3)-P 键的裂解,用 Co2 进行苯甲基鏻盐的电还原羧化
标题:通过 C(Sp3)-P 键的裂解,用 Co2 进行苯甲基鏻盐的电还原羧化
摘要:在此,通过c(Sp 3 )-P键的断裂实现了苄基鏻盐的电还原羧化,并且可以通过该策略合成各种有价值的芳基乙酸.此外,基于对照实验和先前的研究,提出了一个合理的反应机理来解释反应过程.该方法的建立将为烷基鏻盐的功能化提供新的范例.
Doi:10.1039/d4Ob00838C

专利信息

专利号:US-7612210-B2
优先权日:2005-12-05
标题:Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
发明人：MAHANEY PAIGE ERIN; ANTANE MADELENE MIYOKO; SUN JERRY SHUNNENG
权利人:WYETH CORP
摘要:A process for the enantioselective synthesis of an (S)- or (R)-1-[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol and analogues or salt thereof are described. The method involves the steps of (a) reacting an (S) or (R) 4-benzyloxazolidinone with a mixed anhydride of a methyoxyphenylacetic acid under conditions which form a oxazolidinone, (4S)- or (4R)-4-benzyl-3-[methyoxyphenyl]acetyl]-oxazolidin-2-one, (b) treating the (4S)- or (4R)-4-benzyl-3-[(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one with an aprotic amine base and titanium chloride in a chlorinated solvent under conditions which permit formation of the corresponding anion, (c) mixing the corresponding anion with titanium chloride and cylcohexanone under conditions which permit an aldol reaction to form the corresponding (4S)- or (4R)-4-benzyl-3-[(2R)-2-(1-hydroxycyclohexyl)-2-(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one,(d) hydrolyzing the (4S)— or (4R)-4-benzyl-3-[(2R)-2-(1-hydroxycyclohexyl)-2-(methoxyphenyl)acetyl]-1,3-oxazolidin-2-one to form a chiral acid (2S or 2R)-(1-hydroxycyclohexyl)-methoxyphenyl)acetic acid, (e) coupling the chiral phenylacid to a secondary amine to form an amide, and (f) reducing the amide to form an (S) or (R) 1[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol or a salt thereof.

专利号:US-2007135449-A1
优先权日:2005-12-05
标题:Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols

专利号:CA-2629609-A1
优先权日:2005-12-05
标 题 :Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols

专利号:CN-101321741-A
优先权日:2005-12-05
标题 :Process for the selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols

专利号:EP-1957470-A1
优先权日:2005-12-05
标 题:Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols

专利号:WO-2007067501-A1
优先权日:2005-12-05
标题:Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols