CAS: 20290-10-2; Morphine 6-β-D-Glucuronide

欧盟法规

[ECHA物质

上下游产品

uridine-diphosphate-glucuronic acid triammonium salt MORPHIN di(morphin-3-yl) terephthalate methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-α-D-glucopyranuronate

📜吗啡置于lithium Hydroxide,Phosphate Buffer,Sodium Methylate,Silver Carbonate体系中,用 甲醇,甲苯 用作溶剂,化学反应 0.5H,反应生成甲醇:水(1:1)测试标样(吗啡-6-β-D-葡糖苷酸)
参考文献:Synthesis Of [1-3H]Morphine-6-β-D-Glucuronide
标题:Synthesis Of [1-3H]Morphine-6-β-D-Glucuronide
摘要:
Doi:10.1002/(Sici)1099-1344(199909)42:9<851::Aid-Jlcr247>3.0.Co;2-G

专利信息

专利号:US-5908927-A
优先权日:1996-05-22
标 题 :Synthesis of deuterated opiate glucuronides
发明人：NGUYEN HOA DUC; NGUYEN DUC TIEN; SCHEP RAYMOND ALBERT; NGUYEN TRINH DUC; PHAM PHUONG THI NGOC
权利人:HIGH STANDARD PRODUCTS CORP
摘要:A method of synthesizing deuterated morphine-3β-glucuronide, morphine-6β-glucuronide, and codeine-6β-glucuronide is disclosed. The chemicals are used as internal standards for mass spectrometry analyses of morphine, heroin, and codeine uses. They are also useful in the study of metabolism of morphine and codeine.

专利号:US-8481501-B2
优先权日:2004-05-28
标 题 :Synthesis of metabolically stable analgesics, pain medications and other agents
发明人：CASHMAN JOHN R; MACDOUGALL JAMES M
权利人:CASHMAN JOHN R; MACDOUGALL JAMES M; HUMAN BIOMOLECULAR RES INST
摘要:Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.

专利号:US-8258298-B2
优先权日:2008-12-10
标 题 :Synthesis of morphine-6-glucuronide or one of the derivatives thereof
发明人：DLUBALA ALAIN; TRECANT CLAIRE; RIPOCHE ISABELLE
权利人:DLUBALA ALAIN; TRECANT CLAIRE; RIPOCHE ISABELLE; SANOFI SA
摘要:The disclosure relates to a method for preparing morphine-6-glucuronide or one of the deritives thereof comprising reacting a compound of formula (I): n nwherein R 1 is as defined in the disclosure,n nwith a glucuronic acid derivative of formula (II):n n nwherein PG, X, and R 4 are as defined in the disclosure,n nin the presence of an aromatic solvent and trimethylsilyl trifluoromethanesulfonate;n n(ii) reacting the product obtained in step (i) with a strong basic agent; and then (iii) recovering the product obtained in step (ii).

专利号:ES-2470666-T3
优先权日:2008-12-10
标题 :Synthesis of morphine-6-glucuride or one of its derivatives

专利号:CA-2746428-A1
优先权日:2008-12-10
标题:Synthesis of morphine-6-glucuronide or one of the derivatives thereof

专利号:FR-2680786-A1
优先权日:1991-09-04
标 题:PROCESS FOR THE SYNTHESIS OF GLUCURONIDES OF 4,5-EPOXY MORPHINANES.