CAS: 138112-76-2; Agomelatine

上下游产品

CAS号108-24-7 乙酸酐 | CAS号138113-08-3 2-(7-甲氧基萘-1-基)乙腈 | CAS号138113-09-4 7-甲氧基-1-萘乙胺 | CAS号1352139-51-5 N-(2-(7-甲氧基-3,4... | CAS号139525-77-2 2-(7-甲氧基萘-1-基)乙胺盐酸盐 | CAS号75-36-5 乙酰氯 | CAS号77-78-1 硫酸二甲酯 | CAS号152302-45-9 N-(2-(7-羟基萘-1-基... | CAS号152302-45-9 N-(2-(7-羟基萘-1-基... | CAS号686319-38-0 N-[2-(3-bromo-7...

N-[2-(1-Hydroxyl-7-Methoxy-1,2,3,4-Tetrahydro-Naphthalen-1-yl)Ethyl]-Acetamide置于盐酸,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 二氯甲烷,水,乙酸乙酯 用作溶剂,化学反应 2.0H,反应生成阿戈美拉汀
参考文献:Agomelatine Intermediates And Preparation Method Thereof
标题:Agomelatine Intermediates And Preparation Method Thereof
摘要:本发明涉及用于制备阿戈美拉汀的中间化合物及其制备方法.本发明用于制备阿戈美拉汀的中间体是以下式子中的化合物a.同时提供了两种新的中间化合物.当我们使用这些新的中间化合物来制备阿戈美拉汀时,操作简单,控制非常好,纯度高,无需如精馏和柱层析分离等复杂操作,适合工业生产.同时,这两种新中间体本身的制备方法简单且产率高,只需使用最常用的7-甲氧基四氢萘作为原始起始材料,经过一步反应即可获得中间体,然后再进行一步将中间体化合物转化为所需的产品阿戈美拉汀.与以往制备阿戈美拉汀的技术相比,本发明的反应过程大大简化,反应产率提高,克服了以往方法中净化困难的问题.通常情况下,本发明的收率超过70%.

专利信息

专利号:US-7479569-B2
优先权日:2004-02-13
标题:Process for the synthesis of (7-methoxy-3,4-dihydro-1-naphthalenyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; GONZALEZ BLANCO ISAAC
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-8436206-B2
优先权日:2007-08-03
标 题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine
发明人：DUBUFFET THIERRY; LECOUVE JEAN-PIERRE; HERMET JEAN-PAUL
权利人:DUBUFFET THIERRY; LECOUVE JEAN-PIERRE; HERMET JEAN-PAUL; SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I) n nApplication of such process in the synthesis of agomelatine.

专利号:US-7994359-B2
优先权日:2004-02-13
标题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; BLANCO ISAAC GONZALEZ
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-7999129-B2
优先权日:2004-02-13
标 题:Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine
发明人：SOUVIE JEAN-CLAUDE; BLANCO ISAAC GONZALEZ
权利人:SERVIER LAB
摘要:A process for the industrial synthesis of the compound of formula (I) n nApplication in the synthesis of agomelatine.

专利号:US-9701608-B2
优先权日:2013-12-05
标题 :Process for the synthesis of 7-methoxy-naphthalene-1-carbaldehyde and application in the synthesis of agomelatine
发明人：BRIERE JEAN-FRANÇOÃ?S; LEBEUF RAPHAËL; LEVACHER VINCENT; HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB; LES LABORATORIES SERVIER
摘要:Process for the industrial synthesis of the compound of formula (I):

专利号:US-8871975-B2
优先权日:2011-01-05
标题 :Process for the synthesis of agomelatine
发明人：ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI
权利人:ZARD SAMIR; SIRE BÉATRICE; BOUMEDIENE MEHDI; SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I)