CAS: 13750-81-7; 1-Methyl-1H-Imidazole-2-Carbaldehyde

相似化合物

30148-21-1 17334-08-6 20485-43-2

上下游产品

CAS号616-47-7 N-甲基咪唑 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号67-56-1 甲醇 | CAS号1346749-97-0 N-((1-methyl-1H... | CAS号17334-08-6 1-甲基-2-羟甲基-1H-咪唑 | CAS号51081-36-8 lithium,1-methy... | CAS号288-32-4 咪唑 | CAS号74-83-9 溴甲烷 | CAS号10111-08-7 咪唑-2-甲醛 | CAS号74-88-4 碘甲烷 | CAS号20062-62-8 1-methyl-1H-imi... | CAS号78667-04-6 2-(氯甲基)-1-甲基-1h... | CAS号130632-70-1 1,2-bis-(n-meth... | CAS号124312-73-8 1-甲基-2-咪唑甲胺 | CAS号161500-05-6 1-丙基-1H-咪唑-2-甲醛 | CAS号111851-98-0 1-乙基-1H-咪唑-2-甲醛 | CAS号16975-71-6 1-甲基-2-乙烯基-1H-咪唑 | CAS号17334-08-6 1-甲基-2-羟甲基-1H-咪唑 | CAS号20485-43-2 1-甲基-1H-咪唑-2-羧酸 | CAS号37067-93-9 2-乙炔-1-甲基咪唑

N-甲基咪唑置于sodium Dihydrogenphosphate,二异丙胺体系中,用 四氢呋喃,水,乙酸乙酯,N,N-二甲基甲酰胺 用作溶剂,以53%的收率获得1-甲基-1H-咪唑-2-甲醛
参考文献:Pyruvamide Compounds As Inhibitors Of Dust Mite Group 1 Peptidase Allergen And Their Use
标题:Pyruvamide Compounds As Inhibitors Of Dust Mite Group 1 Peptidase Allergen And Their Use
摘要:本发明一般涉及治疗化合物领域,更具体地涉及某些丙酮酰胺化合物的公式(x)(为方便起见,以下统称为"pva化合物"),该化合物在某些情况下抑制尘螨1组蛋白酶过敏原(例如der P 1,Der F 1,Eur M 1).本发明还涉及包含这种化合物的药物组合物,以及在体外和体内使用这种化合物和组合物来抑制尘螨1组蛋白酶过敏原,并用于治疗由尘螨1组蛋白酶过敏原介导的疾病和疾病,通过抑制尘螨1组蛋白酶过敏原而得到缓解的疾病和疾病;哮喘;鼻炎;过敏性结膜炎;特应性皮炎;由尘螨引发的过敏症状;由尘螨1组蛋白酶过敏原引发的过敏症状;以及犬类特应性.

专利信息

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-2006051291-A1
优先权日:2004-09-07
标题 :Synthesis of radiolabeled sugar metal complexes
发明人：ADAM MICHAEL J; FISHER CARA L; BAYLY SIMON R; ORVIG CHRISTOPHER; LIM NATHANIEL C; STORR TIMOTHY J; EWART CHARLES B
权利人:ADAM MICHAEL J; FISHER CARA L; BAYLY SIMON R; ORVIG CHRISTOPHER; LIM NATHANIEL C; STORR TIMOTHY J; EWART CHARLES B
摘要:The invention provides a method for manufacturing or preparing neutral, low molecular weight 99m Tc-labeled and 186 Re-labeled carbohydrate complexes with an improved radiochemical yield from a simple functionalized sugar, such as glucosamine. In particular the synthesis relies on single ligand transfer (SLT) or double ligand transfer (DLT) reactions for converting a ferrocene compound into a rhenium or technetium tricarbonyl complex. The ferrocene compound may be linked to a sugar through various functional groups including, for example, thio, amino and alcohol functionalities to provide a wide range of radiolabeled sugar complexes that include both water soluble and relatively water insoluble compounds.

专利号:US-7067622-B2
优先权日:2001-06-25
标题 :Method of the solid phase synthesis of pyrrole-imidazole polyamide
发明人：SUGIYAMA HIROSHI; IIDA HIROKAZU; SAITO ISAO; SAITO TAKASHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:It is intended to provide a method of producing a pyrrole-imidazole polyamide whereby a longer pyrrole-imidazole polyamide can be conveniently synthesized and a peptide (protein) can be easily transferred. According to this method, a pyrrole-imidazole polyamide having a carboxylate group which can be excised from a solid phase carrier at its end, makes it possible to directly transfer various functional groups and can exactly distinguish DNA sequences can be efficiently produced. A method of synthesizing a pyrrole-imidazole polyamide characterized by performing automatic synthesis by the solid phase Fmoc method with the used of a peptide synthesizer; a pyrrole-imidazole polyamide having a carboxyl group at its end obtained by this method; a pyrrole-imidazole polyamide having a DNA alkylation agent transferred into the carboxyl group at the end of the above-described pyrrole-imidazole polyamide; and a sequence-specific DNA alkylation method characterized by using the above compound.

专利号:US-8143423-B2
优先权日:2007-03-22
标 题 :N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids
发明人：ZHANG YUGEN; YING JACKIE Y; SEAYAD JAYASREE; WONG FONG TIAN; PATRA PRANAB K
权利人:ZHANG YUGEN; YING JACKIE Y; SEAYAD JAYASREE; WONG FONG TIAN; PATRA PRANAB K; AGENCY SCIENCE TECH & RES
摘要:A process for preparing hydroxamic acids is provided. The process comprises reacting an aldehyde with a nitroso compound in the presence of a N-heterocyclic carbene (NHC) catalyst.

专利号:WO-2008115153-A1
优先权日:2007-03-22
标题:N-heterocyclic carbene (nhc) catalyzed synthesis of hydroxamic acids

专利号:US-10106572-B1
优先权日:2014-07-03
标 题:Supramolecular hacky sacks (SHS), method of synthesis and applications thereof
发明人：RIVERA JOSE M; NEGRON LUIS M
权利人:RIVERA JOSE M; NEGRON LUIS M; UNIV PUERTO RICO
摘要:The invention is directed to small molecules that self-assemble hierarchically to form NPs termed SHS (due to their architectural features). These SHS are composed by precise supramolecules known as Supramolecular G-Quadruplexes (SGQs) which are formed when amphiphilic guanosine (G) derivatives that self-assemble in presence of salt by non-covalent interactions. The resulting SGQs are made of amphiphilic guanosine (G) subunits (with precisely eight subunits at neutral pH (pH>5.7) or sixteen subunits at acidic pH (pH<5.7)). The SGQs are responsive entities that further self-assemble upon an external stimulus, such as an increase in temperature or a change in pH, leading to the formation of the aforementioned SHS.