CAS: 135159-51-2; 4-((1-(Dimethylamino)-3-(2-(3-Methoxyphenethyl)Phenoxy)Propan-2-yl)Oxy)-4-Oxobutanoic Acid Hydrochloride

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CAS号108-30-5 丁二酸酐 | CAS号135261-74-4 1-(二甲氨基)-3-[2-(... | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号135963-42-7 (R,S)-1-[2-[2-(...

2-[2-(3-甲氧基苯基)乙基]苯酚置于sodium Hydroxide体系中,用 2-甲基四氢呋喃,水,甲苯 用作溶剂,化学反应 12.75H,反应生成盐酸沙格雷酯
参考文献:用于制备盐酸沙格雷酯的新方法
标题:用于制备盐酸沙格雷酯的新方法
摘要:本发明目的是公开了一个方便且对环境友好的方法去制备的盐酸沙格雷酯.它涉及到一个由2‑[2‑(3‑甲氧基苯基)乙基]苯酚与环氧氯丙烷(2‑[2‑(3‑methoxyphenyl)Ethyl]Phenol With Epoxychloropropane)自由缩合的溶剂.在大气压下用二甲胺将所得中间体的环氧乙烷开环,然后与琥珀酸酐反应得到沙格雷酯.利用异丙醇ipa.Hcl处理获得的游离碱,得到盐酸沙泊格雷酯.在丙酮中形成盐酸盐的结晶,得到纯净产物.该制备方法在第一步中采用无溶剂反应,在第二步中采用大气压反应,因此该制备方法适用于工业生产.

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:US-2016046560-A1
优先权日:2013-04-05
标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:WO-2014165816-A1
优先权日:2013-04-05
标 题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.