CAS: 115520-21-3; Fmoc-Cys(Trt)-Opfp

该化合物是氨基酸cysteine的一种受保护衍生物,通常用于peptide合成和研究中,该化合物的特点是苯基酯组,该组增强了其稳定性和溶性,使之适合各种化学反应.Fmoc(9-氟烯基甲基碳基)组作为氨基功能的临时保护组,允许在cystene的硫醇组有选择地作出反应.三丁基锡化合物组为硫醇提供额外保护,防止在合成过程中出现不想要的反应.五氟苯基乙基酯的出现有助于该化合物在有机溶剂中的再活性和溶性.该化合物通常用于含有细胞残留物的丙酸硫化物合成,特别是在形成脱硫联结或引入特定功能时.该物质独特的结构特征使它在医药化学和peptide设计领域成为有价值的中间体.

结构式图片

相似化合物

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CAS号14533-84-7 三氟乙酸五氟苯酯 | CAS号103213-32-7 Fm°C-S-三苯甲基-L-半胱氨酸 | CAS号771-61-9 五氟苯酚

合成工艺路线路线简述

    五氟苯酚置于吡啶体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 0.75H,反应生成N-芴甲氧羰基-S-三苯甲基-L-半胱氨酸五氟苯酯
    参考文献:Preparation Of Pentafluorophenyl Esters Of Fmoc Protected Amino Acids With Pentafluorophenyl Trifluoroacetate
    标题:Preparation Of Pentafluorophenyl Esters Of Fmoc Protected Amino Acids With Pentafluorophenyl Trifluoroacetate
    摘要:
    Doi:10.1016/s0040-4039(00)97976-0

    专利信息


    专利号:US-9695214-B2
    优先权日:2013-03-15
    标 题 :Solid phase peptide synthesis processes and associated systems
    发明人:SIMON MARK DAVID; PENTELUTE BRADLEY L; ADAMO ANDREA; HEIDER PATRICK LOUIS; JENSEN KLAVS F
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

    专利号:WO-9837097-A1
    优先权日:1997-02-21
    标 题:Msh-receptor subtype selective cyclic peptides
    发明人:WIKBERG JARL; MUCENIECE RUTA; MUTULIS FELIKSS; PRUSIS PETERIS; SCHIOETH HELGI-BIRGIR
    权利人:WAPHARM AB; WIKBERG JARL; MUCENIECE RUTA; MUTULIS FELIKSS; PRUSIS PETERIS; SCHIOETH HELGI BIRGIR
    摘要:Cyclic MC-receptor activating and/or blocking peptides of general formula (I) in which LRG is a large aminoacid and L is 26-29 membered linker connecting LRG and Trp are useful for treating conditions related to eating, body weight, motivation, learning, memory, behaviour, inflammation, body temperature, pain perception, blood pressure, heart rate, vascular tone, natriuresis, brain blood flow, nerve growth, placental development, aldosteron synthesis and release, thyroxin release, spermatogenesis, ovarian weight, prolacting and FSH secretion, uterine bleeding in women, sebum and pheromone secretion, blood glucose levels, intrauterine foetal growth, as well as other events related to parturition, and to afford neuroprotection. The novel peptides can also be labeled and be incorporated into pharmaceutical compositions.
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    合成参考文献


    参考文献:10.1385/1-59259-783-1:349
    摘要:Knight CG, Onley CM, Farndale RW. Peptide synthesis in the study of collagen-platelet interactions. Methods Mol Biol. 2004;273():349–64. doi: 10.1385/1-59259-783-1:349.
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