乙二醇单丁醚置于sodium Hydroxide,乙醚,三溴化磷,2,3-二甲基苯胺体系中,化学反应生成乙烯基正丁醚 参考文献:Measuring New Zealand'S Gdp 1865-1933: A Cointegration-Based Approach 标题:Measuring New Zealand'S Gdp 1865-1933: A Cointegration-Based Approach 摘要:Official And Semi‐official Estimates Of New Zealand'S National Income Are Available On An Annual Basis For The Years Since 1932. Retrospective,Non‐official,Estimates Are Available From 1859. Chiefly These Are Constructed Following Doblin'S (1951) Pioneering Use Of Money Stock Data,Velocity,And The Implications Of The Quantity Theory Of Money,And Include The Estimates Of Hawke (1975),Rankin (1992) And Cashin (1995).This Paper Estimates New Zealand Real Gdp Per Capita With Monetary Data Using Valid,Intervention‐free,Cointegration Methods. The New Measures Avoid The Ad Hoc Adjustments Found In Rankin (1992),Yet Unlike Cashin (1995),They Incoporate Specific New Zealand Monetary Features. The New Time Series Conform Well With Independent Benchmarks And The Historiography Of The Pre‐1914 Period. Alternatively,They Suggest An Interpretation Of New Zealand'S Growth Experience For Years Around World War One Which Differs From That Of Australia,And From The Findings Of Rankin (1992) And Cashin (1995). Doi:10.1111/j.1475-4991.2000.Tb00847.X
专利号:US-5118853-A 优先权日:1988-10-13 标题:Processes for the synthesis of 3-disubstituted aminoacroleins 发明人:LEE GEORGE T; REPIC OLJAN 权利人:SANDOZ LTD 摘要:Process for the synthesis of compounds of the formula ##STR1## comprising the steps of (i) reacting a compound of the formula ##STR2## with oxalyl chloride or oxalyl bromide to form the corresponding compound of the formula ##STR3## (ii) reacting said compound of the formula ##STR4## with a compound of the formula ##STR5## to form the corresponding compound of the formula ##STR6## (iii) hydrolyzing said compound of the formula ##STR7## to obtain the corresponding compound of the formula ##STR8## the use of the compounds of the formula ##STR9## for the synthesis of the compounds of the formula ##STR10## and the use of the intermediates of Formula VII for the direct synthesis of the compounds of Formula II, n wherein n R 1 is C 1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 1b is phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 2 is C 1-3 alkyl, n one of R 3 and R 4 is ##STR11## and the other is primary or secondary C 1-6 alkyl not containing an asymmetric carbon atom, C 3-6 cycloalkyl or phenyl-(CH 2 ) m -, n wherein n R 7 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, n R 8 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, n R 9 is hydrogen, C 1-2 alkyl, C 1-2 alkoxy, fluoro or chloro, and n m is 1, 2 or 3, with the provisos that not more than one of R 7 and R 8 is trifluoromethyl, not more than one of R 7 and R 8 is phenoxy, and not more than one of R 7 and R 8 is benzyloxy, n R 5 is hydrogen, C 1-3 alkyl, n-butyl, i-butyl, t-butyl, C 3-6 cycloalkyl, C 1-3 alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, phenoxy or benzyloxy, and n R 6 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, trifluoromethyl, fluoro, chloro, phenoxy, or benzyloxy, with the provisos that not more than one of R 5 and R 6 is trifluoromethyl, not more than one of R 5 and R 6 is phenoxy, and not more than one of R 5 and R 6 is benzyloxy, n R 10 is C 1-6 alkyl, each X is chloro or bromo, and each X.sup.⊖ is chloride or bromide.
专利号:US-11465970-B2 优先权日:2017-12-14 标题 :Method for synthesis of Roxadustat and intermediate compounds thereof 发明人:XU YONGXIANG 权利人:NANJING CAVENDISH BIO ENGINEERING TECH CO LTD; XU YONGXIANG; NANJING CAVENDISH BIO ENG TECH CO LTD 摘要:The present application provides a method for synthesis of Roxadustat. A compound as represented by formula (VIII) is used as a raw material, and is reacted with phenol, a vinyl-containing ether, an acid, hydroxylamine, and then the product is reacted with glycine. In addition, the present application also provides intermediate compounds as represented by formula (IX), formula (XI), formula (XII), formula (IV), and formula (V) for synthesis of Roxadustat. Herein, details of the substituents involved in formula (VIII), formula (IX), formula (XI), and formula (XII) are stated in the description
专利号:EP-0842924-B1 优先权日:1996-11-14 标 题 :Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists 发明人:WRIGHT STEPHEN WAYNE 权利人:PFIZER 摘要:The present invention relates to certain compounds of the formula (I), which are useful in the synthesis of certain beta -adrenergic receptor agonists. The invention also relates to a process for synthesizing the compounds of formula (I) and to compounds of the formula (II), wherein R<1>, R<2> and R<4> are defined herein, which are useful in the synthesis of the compounds of formula (I). The invention also relates to a process for synthesizing a compound of formula (II). The invention further relates to processes for synthesizing compounds of formula (Z*), R<1>, R<2> and Y<2*> are defined herein.o
专利号:US-5290946-A 优先权日:1988-10-13 标 题 :Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes 发明人:LEE GEORGE T; KAPA PRASAD K; REPIC OLJAN 权利人:SANDOZ LTD 摘要:A process for synthesizing compounds of the formula ##STR1## utilizing, as intermediates, oxalyl chloride or bromide and compounds of the formulae R 1 R 2 N--CHO and CH 2 â•?CH--O--R 10 are processes for synthesizing compounds of the formula ##STR2## utilizing, as intermediates, compounds of Formula I wherein R 1 is phenyl or substituted phenyl or intermediates in the synthesis of the compounds of formula I which intermediates have the formula ##STR3## wherein R 1 is C 1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C 1-3 alkyl, C 1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), n R 2 is C 1-3 alkyl, n R 10 is C 1-6 alkyl, n X.sup.⊖ is chloride or bromide, and n R 3 -R 6 are as defined in the specification. n The compounds of Formula II are intermediates in the synthesis of known HMB-CoA reductase inhibitors which inhibit the biosynthesis of cholesterol and are useful as antihyperchloesterolemic gents.
专利号:US-4794199-A 优先权日:1984-07-05 标题:Process for synthesis of primary amines from olefins, syngas and ammonia 发明人:LIN JIANG-JEN; KNIFTON JOHN F 权利人:TEXACO INC 摘要:This invention concerns the synthesis of primary amines from olefins, synthesis gas and ammonia via an amination process in the presence of a cobalt catalyst, an ether solvent and a tertiary group VB donor ligand.
专利号:US-10870649-B2 优先权日:2017-04-13 标题:Synthesis of NIR fluorescent probe 发明人:LATTUADA LUCIANO; BUONSANTI FEDERICA; CRIVELLIN FEDERICO; FERRETTI FULVIO; MAISANO FEDERICO; ORIO LAURA; PIZZUTO LORENA 权利人:BRACCO IMAGING SPA 摘要:The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
摘要:Toyota, S.; Iwanaga, T., Science of Synthesis, (2010) 45, 753. 摘要:Drabowicz, J.; Kiełbasiński, P.; Łyżwa, P.; Mikołajczyk, M.; Zając, A., Science of Synthesis, (2009) 42, 741. 摘要:Michalak, M.; Gulajski, L.; Grela, K., Science of Synthesis, (2010) 47, 392. 摘要:Palframan, M. J.; Parsons, A. F., Science of Synthesis, (2009) 48, 652. 摘要:Diver, S. T., Science of Synthesis, (2009) 46, 125.